Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"Hexokinase 2"”.
-
Unbiased global proteomic profiling of patient-derived meningiomas of all grades to identify molecular signatures of differentially expressed proteins and phosphoproteins.
… high-grade meningiomas was the glycolytic enzyme hexokinase-2, involved in cellular metabolism. In summary, we generated a proteomic thesaurus of meningiomas in order to decipher aberrantly expressed proteins and activated pathways; this body of knowledge will eventually lead to the identification …
-
Study of the differential compartmentation and functions of hexokinase isoforms and implications for cancer metabolism
… to this highly glycolytic phenotype is hexokinase 2 isoform (HK2), which is significantly overexpressed in many tumors but not in normal adult tissue. Several small molecule inhibitors targeting HK have exhibited promising anticancer activity. However, these small molecule inhibitors …
-
Regulation of hnRNP A1 Cellular Localization by Protein Kinases and its Biological Impact
Human Rhinoviruses (HRVs) utilize Internal Ribosome Entry Sites (IRES) to drive viral protein synthesis. IRESs are specialized RNA elements present within the 5’ UTR of mRNAs that recruit ribosomes independently of the 5’ m7G cap structure. hnRNP A1 (heterogeneous nuclear ribonucleoprotein A1), a …
-
DIFFERENTIAL EFFECTS OF GROWTH FACTORS ON GLYCOLYSIS IN OVARIAN CANCER CELLS
… by LPA and EGF was the robust induction of hexokinase 2 (HK2) that stimulates irreversible entry of glucose to the glycolytic pathway. However, insulin and IGF-1 only weakly induced HK2 expression. Further experimental evidence using HK2 inhibitors indicated that HK2 up-regulation was the …
-
Investigating HK2 as a potential therapeutic target in glioblastoma
… is crucial for the advancement of treatment. Hexokinase 2 (HK2) has a prominent role in glycolysis, acting as the rate-limiting step in the pathway. HK2 is highly expressed in many cancers and its role as the rate-limiting step of glycolysis may potentially contribute to tumour growth. …
-
ApoE2-Mediated Neuroprotection Against Alzheimer’s Disease: from Mechanism to Translation
… glycolytic function through upregulation of hexokinase 1 (HK1) protein expression and enzymatic activity as compared to ApoE4 neuron-like cells. Introduction of the ApoE2 gene, but not the ApoE3 gene, into the ApoE4 genotype significantly ameliorated ApoE4-associated glycolytic deficits. …