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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 58 for “"Hexamer"”.
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The role of arylphorin, an insect storage hexamer, in tobacco hornworm, Manduca sexta.
The hypothesis that Manduca sexta arylphorin is a storage protein that provide amino acids for adult protein synthesis was proposed based on its development profile. This study provided experimental evidence supporting this hypothesis. First, preparation of radiolabeled arylphorin of Manduca sexta …
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Mechanism and importance of Mcm2-7 double-hexamer formation during DNA replication initiation
… DNA replication begins with loading of two heterohexameric Mcm2-7 helicases around origin DNA during G1 phase. The two helicases are loaded in opposite orientations and interact with each other at their N-terminal domains to form a head-to-head "double hexamer". In S phase, the helicases are …
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Part I: Crystal Engineering Using Trimesic Acid Analogs. Part II: An Extremely Stable Hydrogen-Bonded Hexamer
… 11 and 23, suggest that the aggregate is a hexamer.
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The Effect of PEG-Insulin and Insulin Hexamer Assembly on Stability in Solution and Dry Powders. Hexamer Assembly of PEGylated-Insulin and Insulin Studied by Multi-Angle Light Scattering to Rationally Choose the pH and Zinc Content for Analytical Methods and Formulations of Dry Powders.
… could modulate the ionic interaction and reduce hexamer formation at alkaline conditions was investigated. Experiments were designed to measure the level of hexamer with light scattering, and the amount of hexamer was then correlated with the pH and zinc content of the solutions. The importance …
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Multiple roles of the replication initiation protein Cdtl during helicase loading in S. cerevisiae
… eukaryotic replicative DNA helicase, the hetero-hexameric Mcm2-7 complex. As cells enter G1 phase of the cell cycle, all potential sites of replication initiation are selected by the loading of inactive Mcm2-7 double hexamers. The anti-parallel orientation of the Mcm2-7 hexamers within the double …
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Growth and Carboxysome Composition of the Csosia Pore Mutants of <i>Halothiobacillus neapolitanus</i>
… shell proteins, CsoSl A, B, and C, form hexamers which tile together to form the facets of the thin shell. Each hexamer has a small central pore that may play a role in metabolite flux. Using predicted structural models, a specific amino acid within the conserved hexamer pore motif …
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Single-molecule studies of eukaryotic helicase loading
… initiation is the loading of the heterohexameric Mcm2-7 helicase. In eukaryotes helicase loading is tightly regulated to ensure that this event only occurs during the GI phase of the cell cycle. Because helicase activation can only occur once cells enter S phase, cells can only load and …
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NMR study of 2-ethylhexyllithium aggregate and 2- ethylhexyllithium/lithium 2-ethyl-1-hexoxide mixed aggregates.
… that 2- ethylhexyllithium exists solely as a hexamer in cyclopentane solution over the temperature range from 25 to -65 °C. Furthermore, 2-ethylhexyllithium and lithium 2- ethyl-1-hexoxide were shown to form mixed aggregates when the alkoxide was formed in situ by reacting 2-ethylhexyllithium …
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An NMR Study of Trimethylsilylmethyllithium Aggregates and Mixed Trimethylsilylmethyllithium/Lithium trimethylsilylmethoxide Aggregates
… aggregation states were assigned as octamer and hexamer. Low temperature 13C and 6Li NMR peak intensities indicated an equilibrium exists between the two aggregates that shifts toward the octamer as the temperature decreases. ΔH was calculated to be 5.23 + 0.15 kcal/mol and ΔS was calculated to …
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Molecular Encapsulation in Kinetically Trapped, Hydrogen-Bonded Pyrogallolarene Hexamers
<p>Pyrogallolarene and resorcinarene hexamers are hydrogen-bonded capsules that self-assemble in the solid state and can be studied in gaseous and solution phases. Guest loading within pyrogallolarene hexamers in solution has primarily been comprised of solvent molecules with some tertiary amines. …
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An ORC Flip Enables Bidirectional Helicase Loading
… around the origin DNA in a head-to-head double hexamer. This conformation prepares the helicases to initiate bidirectional replication upon entry into S-phase. Interactions between three proteins and the Mcm2-7 helicase guide eukaryotic helicase loading. The origin-recognition complex (ORC) …
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Identifying the requirement and mechanism of the dynamic yet kinetically stable ClpXP interface
… chamber, cooperates with an attached AAA+ hexamer that recognizes, unfolds and translocates the protein substrate into the degradation chamber. The interaction between the AAA+ hexamer and peptidase must be specific and stable enough to ensure efficient degradation. However, information …
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ClpX interactions with ClpP, SspB, protein substrate and nucleotide
… signals. The ClpX component of ClpXP is a hexameric enzyme that recognizes protein substrates and unfolds them in an ATP-dependent reaction. Following unfolding, ClpX translocates the unfolded substrate into the ClpP peptidase for degradation. The best characterized degradation signal is …
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Understanding PilB, The Type IV Pilus (T4P) Assembly ATPase
… PilB crystal structure exhibits an elongated hexamer with 2-fold symmetry indicating a symmetric rotary mechanism model. Except for its structure, the symmetric rotary mechanism of PilB has not been demonstrated experimentally. Its conformation and relatively low activity constrained previous …
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Part I: Self-Assembling Dendrimers Using the Dda-Aad Hydrogen Bonding Motif. Part II: Supramolecular Discotic Liquid Crystals Through Hydrogen Bond Mediated Self-Assembly
… the formation of a hydrogen bonded cyclic hexamer in apolar solvents. The studies by differential scanning calorimetry (DSC), polarized light microscopy (PLM) and X-ray diffraction (XRD) indicate that the hexameric disks can stack in bulk to form thermotropic columnar mesophases. The …
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DJ-1 AND ATP13A2: TWO PROTEINS INVOLVED IN PARKINSON’S DISEASE
… of the DJ-1/ThiJ/PfpI superfamily, adopts a hexameric structure that is necessary for the formation of a catalytic triad, DJ-1 exists as a homodimer and apparently has a catalytic diad rather than a catalytic triad. A recent study has shown that DJ-1Δ15, a truncated form of DJ-1 (15 amino …
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Synthesis of aromatic peptide nucleic acids
… therapeutic agents. A first generation APNA hexamer, composed of monomers of general structure A was synthesized in solution. Thermal denaturation studies failed to indicate if these compounds hybridize to DNA or RNA. The second generation APNA monomers ( B ) were incorporated into PNA …
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The Purification, Properties and Subunit Structure of Glycerol Dehydrogenase
… weight of 3.4 x 10<sup>5</sup> daltons, is a hexamer of a species of molecular weight 5.6 x 10<sup>4</sup> daltons. This species in turn is a dimer of a species of molecular weight 2.8 x 10<sup>4</sup> daltons. Disulfide bonds between the smallest species are responsible for the stability of …
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The role of Orc6 in ORC binding-site switching during helicase loading
… complex (ORC) coordinates loading of two Mcm2-7 hexameric helicases in opposite orientations to form the Mcm2-7 double hexamer. These Mcm2-7 double hexamers mark sites of eventual bidirectional replication initiation upon entering S-phase, when activation of these helicases and recruitment of DNA …
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Gene Expression in Rhodopseudomonas Sphaeroides (Photosynthesis, Carboxylase, Membrane Biosynthesis
… and assembled RuBP carboxylase was a tetramer-hexamer, and assembly of the monomeric subunits to form active enzyme was dependent on the presence of a minimum number of subunits.
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