Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Heteropolymers"”.
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Freezing transition of heteropolymers
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Physics, 1995.
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Energy and topology of heteropolymers
… of topological and energetic properties in heteropolymers. We first study the problem of aggregation of polymers in solution. We find that aggregation is slowed by a transient topological force that exists on time scales shorter than the reptation time. We then study the translocation of a …
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Self-assembly of biological heteropolymers
In this thesis, we are primarily concerned with understanding the complicated geometrical and topological structures that polymers can adopt. We first consider this in the context of chromatin, the polymer of DNA and associated proteins. Our experiments and coarse-grained modeling suggest that …
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Computational Studies of Bio-Inspired Synthetic Random Heteropolymers
Biological heteropolymers, such as proteins and nucleic acids, work together to execute the vast suite of tasks which ultimately enable life. These capabilities, particularly enzymatic function, are incredibly attractive for developing sustainable materials, removing pollutants and contaminants, …
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THERMODYNAMIC PROPERTIES OF THE UNFOLDED ENSEMBLE OF PROTEINS
… The effect of sequence on the properties of heteropolymers is also tested with a randomized version of BBL's sequence. Chain radii of gyration, and the degree and rate of hydrophobic collapse depend on the composition of the sequence, viz. hydrophilic versus hydrophobic content. However, the …
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Computational studies of tau protein : implications for the pathogenesis and treatment of neurodegenerative diseases
… been difficult because it belongs to a class of heteropolymers known as intrinsically disordered proteins (IDPs). Unlike most proteins, IDPs adopt many distinct conformations under physiological conditions. In spite of their disordered nature, evidence exists that such proteins may exhibit …
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Chain dynamical theories of protein folding
… chain: the glassy dynamics expected for heteropolymers with random interactions and the organized dynamics expected for minimally frustrated proteins that fold rapidly on a funneled landscape. The chain dynamical phenomena relevant to both these extremes are studied in this thesis. First, …
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Activation processes in biology
… system. I first show how the forced unfolding of heteropolymers could be a process with non-exponential kinetics, developing ideas about the importance of unfolding pathways in determining kinetics of unfolding. Then, I consider forced unfolding when a molecule is attached to a yielding …
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Design of Single-Chain Polymer Nanoparticles to Mimic Globular Proteins
… polymer nanoparticles (SCNPs) based on random heteropolymers (RHPs) have emerged as a promising platform as both protein stabilizers and mimetics. However, theoretical understanding of the origins underlying their functional versatility has lagged behind experimental advances. Unlike natural …
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Carbon nanotube-based optical sensors for pharmaceutical applications : theory and experiment
… molecular recognition sites from adsorbed heteropolymers. However, to date, deployment of SWCNT-based biosensors has been limited. The aim of this thesis was to study the design and development of SWCNT-based optical sensors for analytes relevant to the food and pharmaceutical industries …