Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"Heterodimerization."”.
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Catalysis of tubulin heterodimerization in vivo
The heterodimerization of α- and β-tubulin represents a critical early step in microtubule morphogenesis. In vitro studies have defined a pathway that mediates the incorporation of monomeric tubulin polypeptides into heterodimer. The components of this pathway, tubulin cofactors, are dispensable …
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Exploring SOD1 electron transfer, heterodimerization, and hetero-amyloid formation.
… natural post-translational modification affects heterodimerization. Chapter four investigates how the aggregation propensity of WT is altered in the presence of two mutations that do not aggregate in vitro.
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Development of Hif-1Α/Hif-1Β Heterodimerization Inhibitors Using A Novel Bioluminescence Reporter Assay System For In Vitro High Throughput Screening and In Vivo Imaging
… hypoxia survival pathway is initiated by heterodimerization of hypoxia-inducible factor (HIF)-1α and HIF-1β, which subsequently upregulates the expression of several hypoxia-inducible genes, promotes cell survival and stimulates angiogenesis in the oxygen-deprived environment. Hypoxic …
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The human Klotho VS variant: focus on the processing and function of the V, S and VS isoforms
… KLVS decreases homodimerization. Changes in heterodimerization of KLVS with fibroblast growth factor receptor (FGFR) 1c were also investigated through co-immunoprecipitation. KLVS increased heterodimerization with FGFR1c. Addition of FGF23, for which KL is a co-receptor, showed that KLVS …
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Targeting The Dimerization Of ERBB Receptor Tyrosine Kinases
… of the EGF receptors themselves and the heterodimerization of EGF receptors with the related ErbB2 receptor. Three sub-projects were completed in the process. The first project explored the feasibility of inhibiting the EGF receptor by targeting receptor dimerization with small molecules. …
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EGFR & HER2 trafficking and signaling dynamics : experimental and modeling studies
… but plays an active signaling role following heterodimerization with a ligand-bound EGFR family receptor. EGFR family receptors undergo a dynamic process termed trafficking in which receptors and ligands are internalized and then either recycled to the surface or targeted for degradation. …
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Modulating cell behavior with engineered HER-receptor ligands
… HER receptors require either homodimerization or heterodimerization with other family members for activation of signaling pathways, and the various dimer pairs are not equivalent in their ability to activate all the downstream pathways. Hence, signaling (and phenotypic) outcomes may be dictated …
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Conditional Protein Alleles and Regulation of Bacterial Transcription: A Thesis in Two Acts
… two inactive fragments which are activated by heterodimerization. By fragmenting the target protein and fusing the pieces to this split intein, we were able to control the target protein's activity through splicing. In the second, which we term Split Ubiquitin for the Rescue of protein Function …
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Total synthesis and anticancer evaluation of all known communesin alkaloids and related complex derivatives
… of (-)-communesin F based on a late-stage heterodimerization and aminal exchange is described. Our synthesis features the expedient diazene-directed assembly of two advanced fragments to secure the congested C3a-C3a' linkage in three steps, followed by a highly efficient biogenetically …
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STRUCTURAL AND FUNCTIONAL STUDIES OF F-BOX-ONLY PROTEIN FBXO7 AND ITS INTERACTIONS WITH PROTEASOME INHIBITOR PI31
… and The Fbxo7-PI31 interaction is mediated by heterodimerization of the FP domains of the two proteins. This work is focus on study the protein structure of the two FP domains in Fbxo7 and PI3. Chapter 1 reviewed the F-box-only protein Fbxo7 biology including the function of Fbxo7 protein in …
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Exploring the mechanism of SHP2 and EGFR/HER2 cooperation in breast cancer cell signaling
… positively mediates signaling. The EGFR/HER2 heterodimerization axis was also explored, uncovering a mechanism by which HER2 is able to protect EGFR from degradation through suppression of phosphorylation at specific sites. Finally, molecular modeling was used to determine how SHP2 is able to …
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Cobalt(II) Catalyzed Asymmetric Hydrovinylation of Alkyl- and Trialkylsilyloxy-1,3-Dienes
… proven to be a capable catalyst to affect the heterodimerization reactions of alpha-olefins with aryl alkenes and 1,3-dienes. The hydrovinylation reaction, the formal addition of a hydrogen atom and an alkene across a pi-system, is an atom economical reaction that allows for the synthesis of …
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Structural Studies of the Bacterial Histidine Kinases RetS and GacS, Key Components of the Multikinase Network that Controls the Switch Between a Motile Invasive Lifestyle and a Sessile Biofilm Lifestyle in Pseudomonas aeruginosa
… was replaced with a heterodimeric interface. Heterodimerization between bacterial HKs is currently a novel observation, but it is likely that other HKs heterodimerize. The RetS-GacS direct interaction can serve as a model for HK-HK binding in multikinase networks.
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Combined experimental and modeling studies reveal new mechanisms in T cell antigen recognition
… by the TCR resulted in active heterodimerization of CD8 and TCR via intercellular interactions. These results indicate that the binding kinetics of the TCR and associated molecules are not static as previously considered and actively change to enhance recognition. The …
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Total Synthesis of Verticillin A and Application of Diazene-Directed Fragment Assembly to the Synthesis of Heterodimeric Epidithiodiketopiperazine Derivatives
… approach disclosed herein enables selective heterodimerization. To demonstrate the utility of heterodimeric ETP derivatives, we have synthesized an ETP-diazirine photoaffinity labelling probe, which we hope can be used to study the interactions of ETPs with cellular targets.
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Caracterización de los genes AtbZIP53 de arabidopsis thaliana y HvbZIP53 de cebada y su participación en la regulación génica durante el desarrollo de la semilla
… in gene regulation during seed maturation by heterodimerization with the bZIP mentioned above. Based on the specific heterodimerization between proteins of the groups C and S1, AtbZIP53 (a member of the later) was identified as a possible candidate implicated in seed gene regulation. The …
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Kh Domains on Brain Polyribosomes: FMRP and Nova in Translational Regulation
… of FMRP. Kissing complex RNA does not disrupt heterodimerization between FMRP and FXR1 or FXR2. We conclude that the mental retardation associated with the I304N mutation, and likely the Fragile-X syndrome more generally, may relate to a crucial role for RNAs harbouring the kissing complex …
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Analyse und Visualisierung eines R2R3-MYB / bHLH Transkriptionsfaktorkomplexes aus Arabidopsis thaliana
… BHLH proteins showed homodimerization as well as heterodimerization with different members of subgroup IIIf, while MYB proteins are only able to interact with bHLH proteins.
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Mechanistic study of aryl hydrocarbon receptor nuclear translocator (ARNT)-mediated signaling
… and (2) nuclear GFP-Ainpl inhibits HIF-1α/ARNT heterodimerization. The suppression of Ainpl on HIF-1α signaling was reversed by introducing ARNT into the cells using transient transfection. We further utilized HIV TAT protein transduction domain to deliver 6His-TAT-Ainpl into three different …
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TCF4 Is a Key Mediator of Cell Identity and Oncogenesis in Neuroblastoma
… contributes to these identity states through its heterodimerization with cell identity specific bHLH TFs. Mechanistically, we show that TCF4 promotes cell proliferation through direct transcriptional regulation of a MYC/MYCN oncogenic program. To identify potential therapeutic vulnerabilities, we …
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