Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 178 for “"Heterodimer"”.
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Heterodimer formation and tublin function in S. cerevisiae
… The results reported here demonstrate that the heterodimer formed between Tubl-724p and P-tubulin is less stable than wild type heterodimer. The unstable heterodimer explains several conditional phenotypes conferred by the mutation. We also describe genes that affect formation of the tubulin …
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Regulation of Bile Acid Biosynthesis by Orphan Nuclear Receptor Small Heterodimer Partner
These combined studies should greatly advance our understanding of how bile acid biosynthesis is regulated in both SHP-dependent and SHP-independent pathways. Importantly, these studies for the first time demonstrate that SHP has a short half-life of 20 to 30 minutes. Bile acids and FGF15/19 …
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Chemokine CXCL7 Monomer, Homodimer, and Heterodimer: Structural Insights, CXCR2 Receptor Function, and Glycosaminoglycan Interactions
… and there is also evidence that it could form heterodimers. Currently, nothing is known regarding the structural features of the monomer, dimer, and heterodimer, and the molecular basis by which these various forms mediate receptor and GAG interactions. We have addressed this missing knowledge …
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Chemokine CXCL7 Monomer, Homodimer, and Heterodimer: Structural Insights, CXCR2 Receptor Function, and Glycosaminoglycan Interactions
… and there is also evidence that it could form heterodimers. Currently, nothing is known regarding the structural features of the monomer, dimer, and heterodimer, and the molecular basis by which these various forms mediate receptor and GAG interactions. We have addressed this missing knowledge …
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Elucidating the role of small heterodimer partner (SHP) in metabolism, injury and systemic disease
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-12-01
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DEVELOPMENT OF ANTAGONISTS TARGETING CHEMOKINE RECEPTOR CCR5 AND THE CHEMOKINE RECEPTOR CCR5 – MU OPIOID RECEPTOR HETERODIMER
… pharmacological profile of the putative CCR5-MOR heterodimer and its relation with NeuroAIDS. The structural-activity relationship between the bivalent ligand and the heterodimer was studied with radio-ligand binding assays, functional assays, HIV-1 fusion assays, cell fusion assays, and in silico …
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Modulation of the activity of a key metabolic regulator Small Heterodimer Partner by post-translational modifications
Small Heterodimer Partner (SHP, NR0B2), a member of the nuclear receptor superfamily, is an orphan receptor that lacks a DNA binding domain but contains a putative ligand binding domain. SHP forms non-functional heterodimers with DNA binding transcriptional factors and, thereby, functions as a …
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Characterization of intestinal small heterodimer partner and farnesoid X receptor in bile acid and lipid metabolism
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-08-01
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The Arabidopsis C/S1 bacic leucine Zipper transcription factor network:Impact of heterodimer formation on target gene transcription
Die Heterodimerisierung der basic leucine zipper (bZIP) Transkriptionsfaktoren (TFs) spielt eine wichtige Rolle bei der Regulierung der Genexpression. Zur Analyse der Heterodimerisierung der Arabidopsis thaliana (At) bZIP-Faktoren wurde ein Gateway® basierendes two-hybrid System in pflanzlichen …
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Catalysis of tubulin heterodimerization in vivo
The heterodimerization of α- and β-tubulin represents a critical early step in microtubule morphogenesis. In vitro studies have defined a pathway that mediates the incorporation of monomeric tubulin polypeptides into heterodimer. The components of this pathway, tubulin cofactors, are dispensable …
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Normal microtubule function and the interaction between the pathways for tubulin folding and expression in S. cerevisiae
… Free P-tubulin can arise if the tubulin heterodimer dissociates or if levels of 3-tubulin and cc-tubulin are unbalanced. I am using the toxicity of 3-tubulin to understand the early steps in microtubule morphogenesis. I have found that a mutation of the gene PLP1 allows cells to survive …
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Defining the active form of ribonucleotide reductase from Saccharomyces cerevisiae in vitro and in vivo
… mixed, the Y2 and Y4 homodimers rapidly form a heterodimer that can be activated with iron to form the ... cofactor located in the Y2 subunit. While the apo-Y2Y4 protein is capable of undergoing slow exchange of its protomers, loading of iron into the heterodimer prevents this slow …
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Functional Analysis of the Yku Complex in Telomere Length Regulation
… (Yku) forms, like its human homologue hKu, a heterodimer comprised of a 70kD and an 80 kD subunit. In yeast and mammals, the Ku heterodimer is required for the repair of DNA double strand breaks (DSBs) via nonhomologous end-joining (NHEJ). Interestingly, Ku has been shown to bind to the native …
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Mechanistic studies of the class I ribonucleotide reductases from S. cerevisiae and E. coli.
… results of initial studies on the energetics of heterodimer formation using calorimetric techniques and site-directed mutagenesis are discussed in the context of the structures of Y2Y2, Y2Y4, and Y4Y4. As the discovery of a second R2 subunit is not unique to S. cerevisiae, the potential …
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X-Ray crystal structure of a ribosomal protein S6, S15, S18 : rRNA complex from T. thermophilus, and investigation of conformational changes in 16S rRNA fragments from B. stearothermophilus during ribonucleoprotein assembly
… buttressed by two a-helices and forms a heterodimer with S18, a poorly structured protein with both a-helices and random coil elements. The S6:S18 heterodimer binds across the helix 22, helix 23, helix 23a RNA junction and makes no direct contacts to S15. Time-resolved fluorescence …
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Regulation of tubulin functions in Saccharomyces cerevisiae
… the polymerization of [alpha]/[beta]-tubulin heterodimer subunits to form microtubules. However, there is another class of factors that affect microtubule formation by regulating the steps that precede the polymerization of [alpha]/[beta]-tubulin heterodimer. One of these factors is Rbl2p. …
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Die frühe Infektionsphase von Ustilago maydis
… and bE proteins from different alleles can form heterodimers, triggering downstream cascades of regulatory processes. These control filamentous growth, penetration of the plant surface, growth inside the plant and induction of galls. The aim of this work was the isolation of genes regulated by …
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Sub-Picomolar Detection of SARS-CoV-2 RBD via Computationally-Optimized Peptide Beacons
… beacons contain two peptides, together forming a heterodimer, and a binding ligand between them to detect the presence of S-RBD. In the absence of S-RBD (OFF), the peptide beacons adopt a closed conformation that opens when bound to the S-RBD and produces a fluorescence signal (ON), utilizing a …
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Using affinity purification -- mass spectrometry to identify aryl hydrocarbon receptor nuclear translocator interacting proteins
… of basic helix loop helix proteins. ARNT forms a heterodimer with aryl hydrocarbon receptor (AhR). This heterodimer binds to the dioxin responsive element (DRE) causing the regulation of the gene expression of some enzymes such as CYP1Al. Studies show that the ARNT-AhR heterodimer needs protein …
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