Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 421 for “"Heterocyclic"”.
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Nitrogen-heterocyclic compounds in meteorites
Contains fulltext : mmubn000001_027004074.pdf (Publisher’s version ) (Open Access)
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Synthesis of biologically active heterocyclic compounds
More than 11 million people worldwide are diagnosed with cancer every year. New cancer drugs are required that are more effective and selective. Nitrogen mustard alkylating agents crosslink DNA inhibiting transcription and replication. Use of the mustard pharmacophore as part of a macrocycle allows …
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Synthesis and reactions of heterocyclic compounds
Dipyrido[1,2-c:2',1'-e]imidazolium iodide has been syntesised from 2,2'-bipridy and methylene iodide.
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Synthesis of novel heterocyclic α-amino acids
This thesis describes the incorporation of heterocycles as part of an α-amino acid side-chain. Two methods were adopted. The first involved the alkylation of a pseudoephedrine glycinamide enolate using haloalkanes. The method was validated by making the naturally occurring amino acid phenylalanine. …
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Interactions of platinum compounds with heterocyclic bases.
… of the reaction between K2PtCl4 and the N-heterocyclic bases in aqueous solution have beeD studied. This was best achieved by pre-aquating the PtCl4(2-) and measuring the decrease in concentration of platinum or ligand by AA or UV spectroscopy respectively. It was found that the rate of …
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Synthesis of Novel CYP1 Activated Heterocyclic Anticancer Prodrugs
… isomer to the less toxic cis isomer. Several heterocyclic ring systems were incorporated across the α,β-unsaturated moiety of the chalcones to produce rigid structures, eliminating the possibility of photoisomerisation occurring whilst maintaining the substituted phenyl groups in a trans like …
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Heterocyclic Calix[4]arene Derivatives for Fluorescence Investigations
This project entails the synthesis of a family of novel Schiff base capped calix[4]arenes. These ligands were prepared using three 1,3 bis-bromo-alkyl-disubstituted calix[4]arenes (ethyl, propyl and butyl), and ortho, meta and para substituted di-imine bridged diphenol units. All these reactions …
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Preparation and properties of some polycyclic heterocyclic systems
Typewritten copy
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Synthesis and stabilization of selected heterocyclic aroma compounds
… and alkanone substituted pyrrolines are heterocyclic compounds and are predominant odorants in various foods in which they provide pleasant nutty and roasty aroma characteristics. This study describes the development of technologies for the accurate and precise quantitation of flavor …
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The formation and chemistry of certain heterocyclic dianions
Glutarimide was converted to its dianion by treatment with two molecular equivalents of sodium amide in liquid ammonia. The dianion underwent C-alkylation with numerous alkyl halides, to form 2-alkylglutarimides. Certain of these 2-alkyl derivatives were hydrolyzed to the corresponding …
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Expedient access to C-aryl linked saturated heterocyclic motifs
Over the past decade, there has been a significant increase in the overall degree of saturation in candidate molecules. Increased sp3 character has been linked to a variety of improved physicochemical properties, including greater solubility and an improved likelihood of clinical success. Based on …
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Development of novel heterocyclic compounds as vascular targeting agents
In chapter one the biology of cancer is introduced along with a brief history of drug treatment and the status quo of cancer therapeutics. This includes a general overview of cancer prevalence, carcinogenesis, and biochemistry. The main targets for cancer therapeutics are introduced along with …
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Quinolines: Novel Synthesis and Derivatives of Heterocyclic Bioactive Agents
<p>Tuberculosis is a pulmonary disease that has ravaged the world throughout history. Even today, many developed and developing countries are experiencing this plight, made worse by the scourge of antibiotic-resistant bacteria.</p> <p><em>Mycobacterium tuberculosis's</em> class II …
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The chemistry of some heterocyclic analogues of triphenylmethane dyes
A comprehensive series of triphenylmethane dyes has been synthesised in which the phenyl ring of Malachite Green has been replaced by a 5- or 6- membered heterocycle containing nitrogen, oxygen or sulphur as hetetâacoins. The visible absorption spectra of the dyes have been correlated with the …
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1,1-enediamines and β-substituted enamines in heterocyclic synthesis
The work in this thesis mainly deals with l,l-enediamines and ~ -substituted enamines (push-pull olefines) and their reactions, leading to the formation of a number of heterocycles. Various ~-substituted enamines were prepared by a 'one pot synthesis' in which a l,l-enediamine presumably acts as an …
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Coinage Metal Chalcogenide Clusters with N-Heterocyclic Carbene Ancillary Ligands
… group 11 – group 16 clusters with N-heterocyclic carbene (NHC) ligands. The clusters were prepared from reactive group 11 trimethylsilylchalcogenolate reagents (NHC-M-ESiMe3; M = Cu, Au; E = S, Se, Te) by silane deprotection reactions with phosphine- or phosphite-solubilized group 11 …
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