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Showing 1 to 20 of 256 for “"Heterocycles"”.
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Heterocycles in peptide chemistry
The synthesis of 5-membered heterocyclic rings that bear both amine and carboxylic acid functional groups has been investigated using a 1,3-dipolar cycloaddition reaction strategy. These molecules, on incorporation into a chain of amino acids, have the potential to restrict the conformational …
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Applications for imidazophenanthridine-based heterocycles
… cations (DIPs) and analogous heterocycles have been investigated. The adapted syntheses developed were applied to a range of aryl amines and more elaborate substrates, such as bifunctional aminoquinolinium cations and amino functionalised polyoxometalates (POMs). …
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Halogenated Heterocycles for Drug Discovery
Within a number of industries, and particularly within the pharmaceutical industry, there is a desire for reliable, high yielding routes towards large numbers of valuable small molecules that allow a wide range of products to be synthesised. Heterocyclic compounds are particularly sought after as …
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Complex Heterocycles as Mitochondrial Uncouplers
Small molecule mitochondrial uncouplers are compounds that dissipate the proton motive force independent of ATP synthase that results in increased energy expenditure. Mild mitochondrial uncoupling has therapeutic potential in treating obesity, diabetes, neurological diseases, non-alcoholic …
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N-Heterocycles for Materials and Catalysis
Contains fulltext : 151783.pdf (Publisher’s version ) (Open Access)
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The Polymerisation of Sulphur containing Heterocycles
A number of α-thio-carboxylic acid anhydrocarboxylates and α-thio-carboxylic acid anhydrosulphites have been synthesised by the reaction of the parent α-thio acids with carbonyl chloride (COCL2) and thionyl chloride (SOCL2) respectively. The base-initiated decomposition of the …
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Oxygen and sulphur heterocycles derived from chloroaldehydes
… of structural changes in these six-membered heterocycles, is discussed at length. Some introductory preparative work was done, regarding the potential use of 1,3,5-trithiane 1,3,5-trioxides with three axial sulphoxide groups, as terdentate ligands.
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New lithiation methodologies to 2-substituted nitrogen heterocycles
… and lithiation-arylation of N-Boc heterocycles in the position α to nitrogen as well as in situ infra-red spectroscopic monitoring of lithiation reactions and the application of lithiation-arylation in total synthesis. Chapter 2 details the use of in situ infra-red spectroscopy to …
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METAL-CATALYSED CROSS-COUPLING REACTIONS OF NITROGEN HETEROCYCLES
Described herein are copper-catalysed N-C heteroarylations of benzimidazole, 1-methylbenzimidazolone, imidazole and pyrrole. The products of these reactions then undergo palladium-catalysed C-C cross-couplings with aryl or heteroarylboronic acids under Suzuki-Miyaura conditions to provide a rapid …
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The arylation of 2-pyrones and related heterocycles
2-Pyrones, and related heterocycles such as 2-pyridones, 2-coumarins and 2- quinolones, are useful model substrates to test a novel methodology due to their varied chemical properties. In addition, these moieties possess broad spectrum biological activity. Chapter 1 provides a review of C–H …
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Ruthenium complexes of nitrogen- and sulfur-containing heterocycles
… has resulted in studies on interactions of heterocycles with Ru metal centers and the subsequent reactivities of these complexes.
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Applications of planar-chiral heterocycles in asymmetric catalysis
The development of planar-chiral heterocycles for asymmetric catalysis and their applications to enantioselective processes were investigated. Reactions including the kinetic resolution of propargylic alcohols, the enantioselective ring opening of meso epoxides, and the asymmetric hydrosilylation …
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Synthesis of heterocycles via isocyanide-based multi-component reactions
… multi-component reaction for the synthesis of heterocycles involving the process of insertion of isocyanides into a carbon-palladium bond. The application to the synthesis of oxazolines was explored and was shown to give good yields of 2-aryloxazolines. The reaction conditions developed use a …
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Sulfur Rich Transition Metal-Main Group Heterocycles and Cages
The reactivity of elemental sulfur homocycles has long been postulated to occur via highly reactive thiopolysulfide (S=S) ring intermediates. Consistent with the reactivity associated with these postulated S=S intermediates is that observed for the organoperthiophosphinic acid anhydrides, …
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