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Showing 1 to 11 of 11 for “"Heterochromatin Protein 1"”.
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Regulation of the Heterochromatin Protein 1 by Phosphorylation of Histone H3 and the HP1 Hinge Domain
… formed from DNA, histones, and associated proteins, is the physiological form of genetic information in all eukaryotic cells. Posttranslational modification of histones, such as acetylation, methylation, and phosphorylation, regulates various DNA-dependent processes, ranging from …
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Molekulare und funktionelle Analyse von Windei (CG12340) als Bindungspartner der Histonmethyltransferase Eggless während der Oogenese von <i>Drosophila</i>
… Ruhigstellung des Chromatins und zur Bildung von Heterochromatin durch die Rekrutierung von Heterochromatin Protein 1 (HP1). Eggless (Egg), das Ortholog der humanen Methyltransferase SETDB1, ist für die H3K9-Trimethylierung in der weiblichen Keimbahn von Drosophila notwendig. Hier zeigen wir, dass …
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The synthetic multivulva genes and their suppressors regulate opposing cell fates through chromatin remodeling
… pathway ligand lin-3 EGF. Some class B synMuv proteins are homologs of a Nucleosome Remodeling and Deacetylase (NuRD)-like complex and heterochromatin protein 1 (HP1). In addition to a NuRD-like complex, which deacetylates lysine nine of histone H3 (H3K9), and HP1, we found two histone …
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Advancing Fluorescence Microscopy Techniques for Volumetric Whole-cell Imaging
… conducted, focusing on the dynamics of DNA and Heterochromatin Protein 1 beta (HP1β) within live mouse embryonic stem cells (mESCs), demonstrating the superior performance of the eSPIM. Collectively, this work makes a significant contribution to volumetric fluorescence microscopy, extending our …
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Characterisation of HP1γ in mammalian cells
… biological pathways. The mammalian HP1 (Heterochromatin protein 1) protein family consists of three members: HP1α, β and γ. Each paralogue regulates formation and maintenance of heterochromatin by binding to the repressive chromatin marks H3K9me2/3 with their chromodomains (CDs). Despite …
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Determinants of piRNA precursor transcription and export in Drosophila melanogaster
… cluster loci. These loci, embedded in heterochromatin, are licenced by a protein complex composed of Rhino, Deadlock and Cutoff (RDC). Rhino is a fast-evolving heterochromatin protein 1 family member and while it has been shown to bind to the heterochromatic mark H3K9me3 at piRNA …
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Regulation of Chromosome Segregation by the Chromosomal Passenger Complex
… in the chromosomal dissociation of HP1 (heterochromatin protein 1) in M-phase. The phosphorylation of H3S10 by Aurora B ejects HP1 from its stably methylated histone H3 lysine 9 (H3K9) chromatin binding site, clearly demonstrating the existence of a "methyl/phos switch." While the …
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Characterising the interaction between TRIM28 and members of the Krab-ZFP family in transcription silencing
… as KAP1 or TIF1β) functions as the co-repressor protein for the largest family of transcription factors, namely the Krüppel-associated box-containing zinc finger proteins (Krab-ZFPs). Silencing is initiated by the recruitment of TRIM28 to a target locus by members of the Krab-ZFP. Subsequently, …
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Identifizierung und Charakterisierung von Histonmethyltransferasen in Drosophila melanogaster
… die DNA mit Histonen und anderen chromosomalen Proteinen zu Chromatin komplexiert. Das sich wiederholende Grundelement des Chromatins, das Nukleoso-m, besteht aus je zwei Kopien der Histone H2A, H2B, H3 und H4, um die 146 Ba-senpaare DNA gewunden sind. Durch Kondensierung der Nukleosomenreihen …
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Functional characterization of poly(ADP-ribose) dependent ubiquitin E3 ligase in the DNA damage response
… RNF4 functions in the DNA damage response 8 4. Heterochromatin protein 1 functions in the DNA damage response 9 D. Poly(ADP-ribosyl)ation mediated DNA damage response signaling 10 1. DNA damage induced PARP1 activation 10 2. Free pADPr polymer function in DNA damage response 11 E. Aim of this …
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Funktionelle Analyse der Interaktion und Lokalisation von Replikationsfaktoren und replikationsrelevanten Proteinen in Mauszellen
Zeil dieser Arbeit war die Identifikation von Proteinen, die mit Bestandteilen des für die DNA-Replikation essentiellen präreplikativen Komplexes in der Maus wechselwirken. Hierbei konnten Interkationen des Heterochromatin Proteins 1a mit den Replikationsfaktoren ORC1, ORC2 und CDC6 sowohl in Two …