Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 138 for “"Heterochromatin"”.
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Unlocking Compacted Heterochromatin Through Modulation Of Associated Proteins
… the vital contribution of tightly compacted heterochromatin on cell identity at specific loci. I studied how 97 unique heterochromatin-associated human proteins play a role in heterochromatin-based gene and repetitive element silencing. As H3K9me3 can block cellular reprogramming, we used a …
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Comparative Analysis of Heterochromatin in the Anopheles gambiae Complex
… the greatest challenge remains in assembling the heterochromatin regions, that are repeat rich part and contain relatively low-gene density. Although previously neglected by scientific studies due to its characteristic paucity of genes, heterochromatin is now recognized to be crucial for several …
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A genetic interaction network of constitutive heterochromatin in Caenorhabditis elegans
Constitutive heterochromatin is an epigenetic compartment of animal genomes that is important for gene regulation, chromosome architecture and the maintenance of genome integrity. It is associated with the silencing of gene expression and the repression of repetitive element activity. Constitutive …
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Silencing Through Heterochromatin Formation: The Role of Piwi in Transposon Targeting
<p>Heterochromatin packages a large portion of the genome in eukaryotes, and plays important roles in mitosis, telomere homeostasis, and transposon: TE) control, all necessary to ensure genome stability. A precisely controlled mechanism to designate which regions of the genome should be so packaged …
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Sex And Heterochromatin: An Investigation Of Sexual Dimorphism In Drosophila Melanogaster
… 30% of Drosophila genome is assembled into heterochromatin. Heterochromatin is relatively gene poor, transcriptionally less active and remains condensed during interphase. Previous studies established that roX RNA and some of the Male Specific Lethal (MSL) proteins, all components of the …
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The organization and evolution of heterochromatin in the Anopheles gambiae complex
… typically part of gene poor regions known as heterochromatin, are generally left as unassembled scaffolds that are neglected in many genomic studies. Heterochromatin is a biologically important chromatin state that has roles in gene regulation and genome stability. Exclusion of these chromatin …
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Genetic and mechanistic analysis of heterochromatin spreading in the yeast S.cerevisiae
RNA Polymerase III transcribed tRNA genes are implicated in a wide variety of chromosome organizational functions that includes the ability to act as a boundary to heterochromatic silencing. A tRNA gene has been shown to be a major component of the barrier that prevents spreading of silencing from …
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The role of Arabidopsis thaliana heterochromatin component H2A.W in meiotic recombination
… the centromere-proximal heterochromatic regions. Heterochromatin is compacted with a high DNA density and is enriched in nucleosome occupancy and specific chromatin modifications, including H3K9me2 and DNA methylation. Analysis of histone H2A variants via ChIP-sequencing has revealed that H2A.W is …
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Silencing, heterochromatin, and DNA double strand break repair in Saccharomyces cerevisiae
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Biology, 1999.
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The role of heterochromatin markers in lytic human herpesvirus egress and maturation
… repressed chromatin is referred to as heterochromatin. Chromatin state is controlled by incorporation of histone variants and post-translational modification of histone tails, also called histone marks. Trimethylation of histone 3 at the 9th and 27th lysine residue (H3K9me3 and H3K27me3 …
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Derepression of heterochromatin inactivation by induction of a nearby promoter in Drosophila melanogaster
… of a euchromatic gene placed next to a region of heterochromatin. This compaction into heterochromatin in some instances results in a mosaic phenotype in Drosophila melanogaster. Since its discovery in the 1930's the phenomenon of PEV has been extensively analyzed and many models describing the …
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The Mi-2 Homolog Mit1 Actively Positions Nucleosomes Within Heterochromatin to Suppress Transcription
… regions of the genome known as constitutive heterochromatin. Mit1 is the putative chromatin remodeling subunit of the fission yeast Snf2/HDAC repressor complex (SHREC) and is known to repress transcription at regions of heterochromatin. However, how Mit1 modifies chromatin to silence …
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The Role of Genomic Sequence in the Spatial and Temporal Propagation of Heterochromatin
… element (L5), known to be sufficient to nucleate heterochromatin, to establish <italic>de novo</italic> heterochromatin domains in the <italic>S. pombe</italic> genome to address the role of DNA sequence in shaping the spatial and temporal propagation of heterochromatin. In this thesis, I describe …
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THE EFFECTS OF AGE AND HETEROCHROMATIN ON FREQUENCIES OF ACQUIRED CHROMOSOMAL ANEUPLOIDY IN UNCULTURED HUMAN LEUKOCYTES
While age-related sex chromosomal aneuploidy is a well-characterized phenomenon, the relationship between autosomal loss and age remains unclear. The emergence of the specific and highly sensitive fluorescence in situ hybridization (FISH) technology has enabled investigators to study interphase …
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Regulation of the Heterochromatin Protein 1 by Phosphorylation of Histone H3 and the HP1 Hinge Domain
… and function. One of these effector proteins, Heterochromatin Protein 1 (HP1), plays important roles in heterochromatin formation. It is recruited to chromatin by interaction with methylated lysine 9 of histone H3 (H3K9me). However, it has remained enigmatic how HP1 reversibly dissociates from …
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Single-molecule microscopy reveals details of heterochromatin reorganisation at the onset of mouse ES cell differentiation
… conducted in the Laue lab suggested that heterochromatin might play a key role in the global rearrangement of chromatin as ES cells differentiate. Thus, the first part of the thesis focused on studying the role of heterochromatin protein 1β (HP1β) in this process. HP1β was found to …
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Using S. pombe to Study the Biological Roles of the Histone Deacetylases Sir2 and Clr3 and the DEAD-Box RNA Helicase Ded1
… histone deacetylases (HDACs) Sir2 and Clr3 in heterochromatin formation and cancer associated mutations of the DEAD-box RNA helicase DDX3X, homolog of fission yeast Ded1, in translational control. Heterochromatin in fission yeast is characterized by hypoacetylation as well as methylation of …
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Investigation of factors involved in RNAi-mediated heterochromatic silencing in Schizosaccharomyces pombe
… gene expression and ensures genome stability. Heterochromatin is a repressive form of chromatin found at repetitive sequences such as centromeres, telomeres and transposons. Heterochromatin-mediated silencing of these loci prevents aberrant chromosomal rearrangements and constitutes a platform …
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Role of ORCA and ORC in chromatin organization and DNA replication
… or individual subunits of ORC including heterochromatin organization, telomere and centromere function, centrosome duplication and cytokinesis. Heterochromatic domains are enriched with repressive histone marks, including histone H3 lysine 9 methylation, written by lysine …
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