Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Heteroaromatics"”.
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Late stage 18F-difluoromethylation of N-heteroaromatics
… for the late stage addition of CHF18F to N-heteroaromatics for PET imaging. This methodology proceeds via C-H activation, under flow photoredox conditions. The 18F-difluoromethylation relies on the use of a new 18F-difluoromethylating reagent derived from the Hu’s reagent. This reagent is …
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Synthesis of Partially Saturated Bicyclic Heteroaromatics: sp3-Enriched Scaffolds for Drug Discovery
Recent years have seen an expansion beyond the more druggable biological targets into novel areas of biological space. However, drug discovery campaigns against these challenging targets have been afflicted with low hit rates during screening campaigns and high levels of candidate attrition during …
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The chemistry of mono and multiple anions of methylheteroaromatics
… an approach to a synthetic plan in which methylheteroaromatics offer a simple keystone. At present the use of sodium hydride for the introduction of appropriate building blocks onto a side-chain in heteroaromatics does not appear to have been studied. In this connection the acylation of a series …
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Generation and Transformations of Cationic Heteroaromatic Molecules
… involved fall under the broad class of cationic heteroaromatics either by using such systems directly (chapters one and two) or by forming them during investigation (chapter three). Instead of employing novel methods, the synthetic focus was to use the simplest and shortest possible routes, both …
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Radical decarboxylation strategies for the synthesis of nitrogen-containing heterocycles
Nitrogen-containing heteroaromatics are ubiquitous in nature. In addition, 75% of FDA-approved drugs currently on the market are based on these compounds, establishing them and their analogues as a primary source of therapeutic agents in the pharmaceutical industry. The structural complexity …
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A general catalytic β-C–H carbonylation of aliphatic amines to β-lactams
… C–H activation reactions such as heteroaromatics and thioethers. The second part of this thesis investigates the mechanism of this C–H carbonylation reaction. Interestingly, the reaction was found not to proceed via a traditional C–H carbonylation mechanism comprising of C–H …
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To Design and Develop Semi-Saturated and Unsaturated Bicyclic Heterocycles for Fragment-Based Drug Discovery (FBDD) Campaigns
… flow hydrogenation of fully unsaturated bicyclic heteroaromatics to deliver semi-saturated systems. The latter are further elaborated by using a simple toolkit of reactions in continuous flow.<br/><br/>Chapter 5 describes the human immunodeficiency virus (HIV) and acquired immunodeficiency …
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The synthesis and reactivity of 7-azaindolizines.
… survey of reaction between relevant nitrogen heteroaromatics and DMAD has been reviewed. The reaction between 7-azaindolizines and DMAD gave products involving bonding at the non-bridgehead nitrogen and the adjacent C-8 position or 8-substituent.
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Synthesis and properties of novel macrocycles and related chromophoric benzenoid compounds
… to include other electronic systems such as heteroaromatics and polyenes. An extensive collaborative study of chromophore formation in resorcinarene solutions is also described here. The study reveals that upon oxidation, the reversible conversion to acyclic precursors occur first, and then …
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Stress relief: Exercising Lewis acid catalysis for donor-acceptor cyclopropane ring-opening annulations, a basis for new reaction methodologies
Nature’s biodiversity is complex and filled with beauty and wonder which are all observable on the macroscopic scale. This exquisiteness of nature’s intricacies are mirrored on the molecular level such that substances, large or small, are assembled to serve as signaling molecules, protective …