Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"Hesperetin"”.
-
Biopharmaceutic and Pharmacokinetic Evaluation of Hesperidin and Hesperetin for Ocular Delivery
The bioflavonoid hesperidin and its aglycone hesperetin are promising candidates for the treatment of diabetic retinopathy and diabetic macular edema because of their pharmacological properties. The objective of this project was to characterize the biopharmaceutic and pharmacokinetic …
-
A comparative study of the phosphodiesterase 4 inhibitory activity of artemisia afra, Leonotis leonorus and mentha longifolia plant medicines
… individual flavanoids, especially luteolin and hesperetin, in the three plants and finally, to determine if there was a correlation between the PDE inhibitory activity and the levels of flavanoids or phenolic compounds in the plants. It was hypothesized that the plants with higher levels of …
-
Crystal Engineering of Flavonoids
… engineering of two flavonoids, quercetin and hesperetin, which are already known to exhibit antioxidant properties and reduce cardiovascular effects in humans. However, they have limited bioavailability and poor water solubility. Several new forms of quercetin and hesperetin in the form of …
-
Tropical citrus antioxidants and catabolism of phenolics in green tea, coffee, cocoa and orange juice
… diosmetin-7-O-neohesperidoside, hesperetin-7-O-rutinoside, diosmetin-7-O-rutinoside and hesperetin-7-O-neohesperidoside. Most of the C-glycosylated flavones and dihydrochalcone have not been found previously in tropical citrus. C. microcarpa contained a high amount of …
-
A study of the toxicological properties of propolis samples from Europe and Saudi Arabia and of their biological activity against protozoa
… three compounds from a Saudi propolis sample: Hesperetin-7-methyl ether (14a), Sakuranetin (14b) and Lupeol (15). Both the crude extracts and isolated compounds displayed variable activity against the range of microorganisms which were tested against including S. aureus, T. brucei, C. …
-
The Chemistry of Flavonoids in Model Beverages and Human Milk
… nmol/L), kaempferol (7.8-71.4 nmol/L),hesperetin (74.8-1603.1 nmol/L), and quercetin (32.5-108.6 nmol/L) were present in human milk samples with high inter/intraindividual variability. With the exception of kaempferol, the mean flavonoid content in human milk was not statistically …
-
Using Dictyostelium discoideum to develop flavonoid therapeutics for polycystic kidney disease: the role of MATE transporters
… could then be observed and quantified. Hesperetin and naringenin did not appear to cross the cell membrane, whereas kaempferol, luteolin and quercetin did, with both kaempferol and quercetin being localised to the mitochondria, and some distribution within the cytoplasm.
-
Excessive iron accumulation mediated oxidative stress and β-cell dysfunction via perturbations of insulin secretion in MIN6 cells
… citrus pectin (MCP) used to formulate Fe and hesperetin in the presence/absence of EGCG. These experiments were followed by assessments of cellular iron content, lipid peroxidation, and cell viability at 48 & 72 h. Our results suggest that presence of 100 μM iron exerted the most detrimental …
-
Effects of APOA1/C3/A4/A5 Gene Cluster and Flavonoids Intake on Cardiovascular Disease Risk Factors in U.S. Populations
… epicatechin (68.5±2.3mg/day) and hesperetin (19.1±1.0mg/day). People with high alcohol consumption, low educational level, low-income level, and smokers tended to consume less flavonoids. Tea (32.7%), beers (22.7%), wines (9.8%), banana (9.7%) and citrus fruits (6.8%) were the most …
-
Non-invasive drug delivery to the posterior segment of the eye: Development of formulation strategies and evaluation of ocular distribution and pharmacological activity
… a polymeric matrix film system to deliver Hesperetin (HT), a bioflavanoid, to the posterior segment of the eye. The film is 4 mm x 2 mm in dimension and 0.2 to 0.4 mm in thickness. When the HT-film was tested in vivo in anesthetized rabbit model, HT levels were maintained above the …