Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"Hes5"”.
-
The role of notch signaling in the development of the hypothalamic-pituitary axis and arcuate nucleus
… or expression of the Notch effector gene Hes5. In contrast, mice with expression of activated Notch1 intracellular domain (NICD) within the hypothalamus (NICD Tg) display ectopic Hes5 expression and increased Hes1 expression in the posterior hypothalamus, which is sufficient to cause loss …
-
Regulation der Neurogenese durch bHLH-O-Proteine in Xenopus laevis
… beschränkt, zeigen dass XHes2 im Gegensatz zu Hes5-ähnlichen Genen, wie ESR1 und ESR7, keine Rolle bei der Notch-abhängigen lateralen Hemmung während der primären Neurogenese spielt. In Überexpressionsstudien mit verschiedenen, z.T. Hormon-induzierbaren XHes2-Varianten in Embryonen und animalen …
-
The Tumor Suppressor Notch Inhibits Head and Neck Squamous Cell Carcinoma (Hnscc) Tumor Growth and Progression By Modulating Proto-Oncogenes Axl and Ctnnal1 (Α-Catulin)
… constructs were used to overexpress HES2 and HES5, while shRNA’s was used to knock down AXL and catulin in mutant cell lines to evaluate tumor growth.</p> <p><strong>Results:</strong> We show here that restoration of full length NOTCH1 in mutant HNSCC cell lines and activation of NOTCH …
-
Notch Signaling Inhibited By Ikaros1 In Human T-Cell Acute Lymphoblastic Leukemia
… expression of Notch target genes Hes1 and Hes5 at the transcriptional level. Interestingly, Ikaros inhibits growth more effectively in the cell lines with stronger Notch activation. In addition, Ikaros was shown to inhibit the Notch target gene Hes1 in both Notch dependent and independent …
-
Hormones, Simulated Microgravity and Hypergravity affect Bone and other Physiological Systems in Zebrafish Larvae
… revealed a central network of regulatory genes (hes5, sox10, lgals3bp, egr1, edn1, fos, fosb, klf2, gadd45ba and socs3a) whose expression was consistently affected by the transition from hyper- to normal gravity.
-
Jagged1 regulates adult neural stem cell maintenance and multipotency through activation of Notch1
… Notch-Signalwegs, die Transkripte von Hes1 und Hes5 ein verringertes Exprimierungs-Niveau nach Entfernung von Jagged1 zeigen. Diese Resultate konnten nach bedingter Entfernung von Notch1 aus den neuralen Stammzellen in vitro pheno-kopiert werden. Entfernung des Rezeptors Notch1 führte zu einer …
-
A Developmental Pathway for Epithelial-to-Motoneuron Transformation in C. Elegans
… Down-regulation of the Notch-dependent Hes1 and Hes5 transcriptional inhibitors in differentiating cells induces expression of the proneural bHLH transcription factors Olig2 and Ngn2, leading to adherens junction loss, delamination from the epithelium, cell migration, and neuronal maturation. A …
-
THE ROLE OF NOTCH SIGNALING IN THE DIFFERENTIAL ABILITY OF SUPPORTING CELL SUBTYPES TO SPONTANEOUSLY REGENERATE HAIR CELLS IN THE NEONATAL MOUSE COCHLEA
… The most notable example is the Notch effector Hes5, which is directly responsible for inhibiting HC fate, and was reduced in outer pillar cells and Deiters’ cells, but not in other SC subtypes. From this we conclude that Notch signaling is reduced differentially among SC subtypes. In Aim 2 we …
-
Uncovering the role of notch signaling in development of hypothalamic nuclei in vivo and using in vitro microenvironments
… reduce direct downstream Notch signaling Hes1, Hes5, and Hey1. This coincided with a significant increase in the proneural gene Mash1, suggesting that some of the machinery required for progenitor differentiation was present in cultured progenitors. In vitro results recapitulated some in vivo …