Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Hes-1"”.
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Notch Signaling in Human Neuroblastoma Cells
… Notch expression inhibits this differentiation. These observations imply a role for Notch signaling in the blocked differentiation of neuroblastoma cells. In addition, neuroblastoma cells exposed to hypoxia, a common event of solid tumors, dedifferentiate. During this process, components of the …
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Notch Signaling in Neuroblastoma and Renal Cell Carcinoma
… noted that the expression of the Notch target HES-1 was primarily regulated by ERK-MAP kinase signaling in a neuroblastoma cell line. Clear cell renal cell carcinoma (CCRCC) is characterized by activation of the hypoxia inducible factor (HIF) pathway due to functional loss of the von …
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Anti-Tumor Effects of The Notch Pathway In Gastrointestinal Stromal Tumors
… with some neuroendocrine features, we hypothesized that Notch pathway signaling may play a role in growth, survival and differentiation of GIST cells. To test this hypothesis, we genetically and pharmacologically manipulated the Notch pathway in human GIST cells. In this study, we …
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Regulation of Intestinal Development and Function in Early-Life Pigs
… during the early life of pigs. Collectively, these gaps highlight the need for targeted nutritional or molecular interventions during critical developmental phases during the early life of pigs. Topics examined herein focus on development changes of the gastrointestinal tract. The first study …