Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Herpes simplex virus type 2"”.
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Transcription of herpes simplex virus type 2
Summary available: p. i-iv.
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Characterizing the Role of the Herpes Simplex Virus Type 2 UL21 Protein in Viral Nuclear Egress
The herpes simplex virus type 2 (HSV-2) is an important human pathogen that is the main cause of genital herpes infections and has a significant and wide-ranging impact on human health. HSV-2 infections are one of the most common sexually transmitted diseases and are highly prevalent worldwide, …
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Induction of the <em>Chlamydia trachomatis</em> Persistent State by Herpes simplex Virus Type 2 Does Not Require Productive Viral Replication.
<p>Clinical and epidemiological studies have shown that multiple infection with HSV-2 and <em>Chlamydia trachomatis</em> occurs <em>in vivo</em>. We hypothesize that (i) HSV-2 co-infection of <em>C. trachomatis</em> infected cervical epithelial cells induces chlamydial persistence; (ii) productive …
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The Isolation and Characterization of Growth Regulatory Factors Produced by a Herpes Simplex Virus Type 2 Transformed Mouse Tumor Cell Line, H238
<p>Transformation of cells with herpes simplex virus Type 2 (HSV- 2)occurs by an unknown mechanism. No specific gene or gene product has been consistently associated with HSV-2 transformation as is the case for other tumor viruses. This study was performed in an attempt to associate …
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The Impact of Methamphetamine on Genital Herpes Disease Pathogenesis and Host Immune Responses to Herpes Simplex Virus Type 2 in Mouse and Guinea Pig Models
… an STI pathogen of public health importance, Herpes Simplex Virus type 2 (HSV-2), the primary cause of genital herpes worldwide. The central hypothesis of this dissertation is that METH alters the innate and adaptive immune response, increasing susceptibility to infection and altering genital …
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Co-occurrence of shedding Herpes Simplex Virus type-2 (HSV-2), Human Papilloma Virus (HPV) and Human Immunodeficiency Virus 1 (HIV-1) in the female genital tract among HIV-infected women
Introduction: Human Immunodeficiency Virus remains as one of the largest pandemics in the world, with the prevalence of more than 70% of HIV-infected individual reside in Sub-Saharan Africa. Moreover, other sexually transmitted viral infection such as Human Papillomavirus and Herpes Simplex Virus …
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Influence of helminth infection on vaginal immunity
… reproductive tract and risk of Human Papillomavirus infection in humans was investigated. The influence of helminth infection on B and T cell responses in the female reproductive tract and how this impacts vaccine mediated responses to another viral infection of the female reproductive tract, …
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The Effects of Biological Response Modification and Diet on the Immune Respose of Tumor-bearing mice
… mice were injected s.c. with 10<sup>6 </sup>herpes simplex virus Type 2- Adult male BALB/c transformed (H238) cells in the thigh causing a visible fibrosarcoma within 1-2 weeks. Mice were fed either a diet low in protein (milk) and low in fat (Diet 1), or another diet low in protein (wheat) …
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Suppressive Effects of Transforming Factor-β and Interleukin-10 on the Cytolytic Activity of Murine Macrophages and Reversal by Cytokines
… percent lysis of <sup>3</sup>H-thymidine labeled Herpes simplex virus type 2-transformed tumor cells (H238). After 18-24 hours of incubation with TGF-β or IL-10, the cytolytic activity of macro-medium alone. The immunosuppressive effect of TGF-β or IL-10 on non-activated macrophages was …
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Estradiol and MDMA affect the susceptibility and immune response to genital herpes and genital herpes immunization
Herpes simplex virus type 2 (HSV-2), the most frequent cause of ulcerative genital herpes disease, has infected nearly one-in-five Americans and is even more prevalent in the developing world. The virus is also known to be a synergistic copathogen to HIV and may even facilitate its infection. …
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Evaluation of immunomodulatory compounds for identification of an anti-herpetic innate immune response profile
Herpes simplex virus type 2 (HSV-2) is a prevalent world-wide sexually transmitted infection (STI) that commonly infects the genital mucosa and establishes a life-long latent infection. The virus periodically reactivates producing recurrent shedding episodes that increase the risk of acquiring …
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Clinical Implications of HIV-1, HSV-2 Co-infection and Opportunities for Intervention
… rates of CD4 count change by HSV-2 status (Focus HerpeSelect ELISA) among 218 patients with a past period of ART-untreated follow-up using mixed linear regression models. No significant difference in the rate of CD4 count change was observed in HSV-2 seropositives at +13.6 cells/mm3/year (p=0.12) …
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The Effects of Levamisole, CORYNEBACTERIUM PARVUM, and Unblocked Lymphocytes on Mice Injected with Herpes Virus Type 2-transformed Cells
<p>The association between herpes simplex virus type-2 and carcinoma of the cervix is becoming increasingly strong (Rawls, et al., 1976 ; Rapp and Duff, 1974; Hollingshead, et al-, 1973). This study demonstrates the ability of certain known immunostimulators to beneficially· alter the immune status …
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HIV-1, HIV-2 and other Sexually Transmitted Infections in Guinea-Bissau, West Africa
… Chlamydia trachomatis (12.6%). Infections with Herpes Simplex Virus type 2 and Mycoplasma genitalium were associated with HIV positivity.
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Impact of long-acting contraceptives on female genital tract cytokine profiles in a randomised controlled trial
… and MIP-1α. Women that were seropositive for herpes simplex virus type 2 (HSV-2) had significantly lowerconcentrations of MIP-1α. The copper IUD and LNG implant were associated with rapid increases in inflammatory markers following contraceptive initiation. Pro-inflammatory IL-1β and IL-6 and …
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ANALYSIS OF HERPES SIMPLEX VIRUS ICP0 FUNCTION AND THE ANTIBODY RESPONSE TO A LIVE HSV-2 ICP0- MUTANT VACCINE
<p>Both herpes simplex virus type-1 (HSV-1) and herpes simplex virus type-2 (HSV-2) are human pathogens that are capable of causing significant disease. More than 600 million people are infected with HSV-2 genital herpes and every day >40,000 new HSV-2 infections are transmitted to naïve …
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Effect of Time and Diet on the Immune Status of Mice Challenged with Herpes-transformed Cells
<p>Human Herpes simplex virus type 2 (HSV 2)-transformed Balb/c mouse cells (H238 cells) are malignant in Balb/c mice. The immune stratus of mice bearing H238 cell-induced tumors was studied and changes in immune response with time and with altered diet of the mice were measured.</p> <p>In the …
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