Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"Herpes simplex virus type 1 (HSV-1)"”.
-
The role of gylcoprotein K (gK) in the ocular and neuropathogenesis of herpes simplex virus-type 1 (HSV-1)
<p>Herpes simplex virus type 1 (HSV-1) is a DNA virus that is a ubiquitous pathogen of humans. The hallmark of the HSV-lifecycle is infection of a mucosal surface with spread to sensory neurons where the virus establishes a latent infection with periodic recurrences for the life of the host. The …
-
The Role of Interpersonal Problems in the Relationship Between Early Abuse Experiences and Adult Immune Functioning
… Immunoglobulin A (sIgA) and antibody level for Herpes Simplex Virus Type 1 (HSV-1-sIgA). Participants were divided into three abuse history groups (i.e., no history of abuse, child physical abuse, child sexual abuse). The results failed to support the proposed mediation models. Age and recent …
-
ARMING STRATEGIES TO IMPROVE THE IMMUNOTHERAPEUTIC POTENTIAL OF ONCOLYTIC HERPESVIRUSES
Exploiting the capacity of oncolytic viruses (OVs) to selectively target and destroy tumor cells while triggering robust antitumor immune responses offers a highly promising avenue in cancer immunotherapy. Inside the wide viral repertoire for oncolytic virotherapy, Herpes simplex virus type 1 …
-
Metabolomic comparison of selected Helichrysum species to predict their antiviral properties
… H. aureonitens has antiviral properties against Herpes simplex virus type 1 (HSV-1). In this study, further investigation into the Helichrysum species was undertaken, to establish the active constituents responsible for anti-HSV activity using a metabolomics approach. The cytotoxicity of 12 …
-
Investigating dynein-based transport of intracellular pathogens
… at the perinucleus. Similarly, the neurotrophic virus Herpes Simplex Virus type 1 (HSV-1) undergoes dynein-dependent movement from the axonal tip of sensory neurons to the nucleus. Although the ability of these pathogens to co-opt dynein motors is well documented, the molecular mechanisms …
-
Molecular genetics and functions of Kaposi's sarcoma-associated herpesvirus glycoproteins in viral entry and virus-induced cell fusion
Kaposi’s sarcoma-associated herpesvirus (KSHV) is considered the etiologic agent of Kaposi’s sarcoma and several lymphoproliferative disorders. Recently, the full-length KSHV genome has been cloned into a bacterial artificial chromosome (BAC) and successfully recovered in 293 cells. The herpesviral …
-
The Multifaceted Contribution of Natural Killer Cells During Herpes Simplex Type-1 Viral Infection.
… and inhibitory receptors. During the course of a herpes simplex virus type-1 (HSV-1) infection, NK cells can influence host susceptibility to infection with severe infections occurring in individuals with genetic defects in the NK cell response. In response to HSV infection, NK cells are recruited …
-
Purification of glycoproteins from herpes simplex virus
The aim of this work was to purify type-specific glycoproteins from herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) for diagnostic use. The most likely candidate for a type-specific glycoprotein of HSV-1 is glycoprotein C (gC), although it has recently been shown to contain some type-common …
-
The Syndecan-1 Paradox in HSV-1 Infection and Pathogenesis
Herpes simplex virus type 1 (HSV-1) is a globally prevalent neurotropic virus that establishes lifelong latency within trigeminal ganglionic neurons and undergoes periodic reactivation, resulting in recurrent mucocutaneous and ocular disease. In severe manifestations, HSV-1 infection can progress …
-
Topical Nanoparticulate Formulation of Drugs for Ocular Keratitis
… PLGA-PEG-PLGA polymer gel for the treatment of herpes simplex virus type 1 (HSV-1) induced viral corneal keratitis. NP containing prodrugs of GCV were prepared by a doubleemulsion solvent evaporation technique using various PLGA polymers with different drug/polymer ratios. Cytotoxicity studies …
-
The role of the herpes simplex virus type 1 UL33 protein in DNA packaging
The UL33 gene of herpes simplex virus type 1 (HSV-1) encodes a 130 amino acid (aa) protein that is essential for the cleavage of concatemeric viral DNA into monomeric genomes and their packaging into preformed capsids. Several lines of evidence have suggested that UL33, along with the UL15 and UL28 …
-
Glycoprotein M and ESCRT in herpes simplex virus type 1 assembly
Herpes simplex virus type 1 (HSV-1) has a large linear double-stranded DNA genome in an icosahedral capsid shell, a cell-derived lipid envelope and a proteinaceous tegument layer. There are over fifty viral proteins and many host proteins identified in HSV-1 virions. The final formation of mature …
-
Characterisation of PP71 homologues encoded by mammalian cytomegaloviruses
Human cytomegalovirus (HCMV) is a human pathogen that can cause severe disease in immunocompromised or immunosupressed individuals and also in newborns infected in utero. Transcription of the viral genome occurs by a process in which three classes of HCMV genes, immediate early, early and late are …
-
ANALYSIS OF HERPES SIMPLEX VIRUS ICP0 FUNCTION AND THE ANTIBODY RESPONSE TO A LIVE HSV-2 ICP0- MUTANT VACCINE
<p>Both herpes simplex virus type-1 (HSV-1) and herpes simplex virus type-2 (HSV-2) are human pathogens that are capable of causing significant disease. More than 600 million people are infected with HSV-2 genital herpes and every day >40,000 new HSV-2 infections are transmitted to naïve …
-
Relating the structure of the HSV-1 UL25 DNA packaging protein to its function
The herpes simplex virus type 1 (HSV-1) UL25 protein (pUL25) is a minor capsid protein that is essential for packaging the full-length viral genome into preformed precursor capsid. It is also important in virus entry and recently has been implicated in the egress of the virus from the cell (Coller …