Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Herpes Simplex Virus-1"”.
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Ubiquitin Targets and Molecular Mechanisms of Herpes Simplex Virus 1 Infection in Adult Sensory Neurons
Herpes simplex virus 1 (HSV-1) is a double-stranded DNA virus, often acquired during childhood, that currently infects more than 50% of the human population. The symptoms of infection are herpetic lesions that frequently appear throughout a host's life in response to stress in the orofacial or …
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Modified Green Tea Polyphenol, Palmitoyl-EGCG and Black Tea Theaflavins: Promising Natural Herpes Simplex Virus 1 and 2 Agents
… antiviral properties, including anti-HSV (Herpes Simplex Virus). There is no cure for the diseases caused by HSV infections. While there is a rising concern over the increase in resistant HSV strains, new effective agents for prevention are in critical need to be developed. Green tea’s …
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Stress hormones epinephrine and corticosterone modulate herpes simplex virus 1 and 2 productive infection and reactivation primarily in sympathetic, not sensory, neurons
Herpes simplex viruses 1 and 2 (HSV-1 and HSV-2) infect and establish latency in peripheral neurons, from which they can reactivate to cause recurrent disease throughout the life of the host. Stress is associated with exacerbation of clinical symptoms and induction of recurrences in humans and …
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Differential regulation of herpes simplex virus-1 and herpes simplex virus-2 during latency and post reactivation in response to stress hormones and nerve trauma in primary adult sensory and sympathetic neurons
The contrasting infection strategy of herpes simplex virus (HSV) consists of an initial primary lytic infection in epithelial cells, followed by establishment of lifelong latency in sensory and autonomic neurons of the peripheral nervous system that innervate the site of infection. Any cellular …
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Untersuchungen des adjuvanten Effekts des viralen Tegumentproteins VP22 auf die Induktion Melanom-spezifischer cytotoxischer T-Zellen in C57BL/6 Mäusen nach DNA-Immunisierung
… von TRP-2 an VP22, dem Tegumentprotein des Herpes Simplex Virus 1, gesteigert werden. VP22 besitzt die Faehigkeit, interzellulaeren Transport von Proteinen zu vermitteln, so dass VP22-TRP-2 Fusionsproteine effizienter in professionelle antigenpraesentierende Zellen (APC), den Initiatoren …
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Sensing Foreign DNA: The Role of DNA-PKcs in Human Anti-viral Innate Immunity
… genomic DNA, which is a major PAMP during DNA virus infection. Viral DNA sensing leads to the activation of the STING-TBK1-IRF3 signalling axis and the production of type I interferon. Previously, our work identified the non-homologous end-joining protein DNA-PKcs, part of the DNA-dependent …
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DISSECTION OF HOST-VIRUS INTERACTIONS IN THE HUMAN CENTRAL NERVOUS SYSTEM
… despite antiviral treatment. Neurotropic viruses cause viral encephalitis due to their ability to invade the central nervous system (CNS), and the most common cause is HSV-1. Inborn errors of immunity (IEIs) have demonstrated that neuron, cell type-specific, antiviral immunity is essential …
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Biochemical Evaluation of Lignin-like Molecules
… their effect in preventing cellular infection by herpes simplex virus-1 (HSV-1). Based on previous findings on sulfated lignins a size-dependent study on unsulfated LMWLs was done. The unsulfated lignins were found to not only inhibit HSV-1 entry into mammalian cells, but were more potent than …
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Isolation and characterisation of extracellular vesicles in baculovirus infection of insect cells
The baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is an insect-specific virus. Its infection can be studied in Spodoptera frugiperda. It has a double-stranded DNA genome and a biphasic lifecycle, producing budded virus (BV) to infect neighbouring cells and occlusion …
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Viral subversion of host cell membrane trafficking
Enveloped viruses acquire their membrane coat from the plasma membrane or intracellular organelles and rely on cellular machinery to facilitate envelopment and egress of virus progeny. This thesis examines egress-related interactions between host cell factors and proteins of two different enveloped …
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The role of heterochromatin markers in lytic human herpesvirus egress and maturation
The human herpesviruses are large, double-stranded DNA viruses known for their persistent latent phase. Within the herpesvirus family there are 3 subfamilies; alphaherpesviruses, classified as such because of their more rapid replication and latency in neurons; betaherpesviruses, known for slow …
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Social Support and Viral Reactivation in US and Foreign-Born Mexican Americans
… higher levels of infection and reactivation of herpesviruses that are carcinogenic or associated with cancer, and cancer is one outcome in which Hispanics do not appear to be at an advantage. To more closely understand the relationship between social support, herpesvirus reactivation, race, …
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Sustained release nanoparticles containing acyclovir prodrugs for ocular herpes simplex keratitis and characterization of folate transport proteins in a corneal epithelial cell line
Ocular herpes is a persistent viral infection caused by the herpes simplex virus-1. It is one of the most common infectious diseases causing corneal blindness in the United States. In this study, polymeric nanoparticles of stereoisomeric di-peptide prodrugs of acyclovir (L-valine- L-valine-ACV, …
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Proteomic Investigation of Interferon Alpha Stimulation and Viral Regulation to Identify Candidate Antiviral Restriction Factors
… a critical interface between the cell and the virus, meaning that proteins present here are well situated to act as ARFs. An understating of these ARFs and how viruses interact with them, is crucial to our knowledge of infection and immunity, and provides potential therapeutic targets. In this …
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Structural and functional characterisation of pUL21, an α-herpesvirus phosphatase adaptor protein
… pandemic exemplifies the profound impact viruses can have upon our lives. Virus infection is a complex process where viral proteins cooperate to exploit host cell metabolism while evading immune responses. Herpes simplex virus 1 (HSV-1) is a very prevalent human herpesvirus that causes …
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Investigating the structure and function of HSV-1 tegument proteins: UL7 and UL51
Herpes simplex virus-1 (HSV-1) has a large double-stranded DNA genome encased within an icosahedral capsid. The capsid is surrounded by a protein-rich layer, termed tegument, and a membranous envelope containing viral glycoproteins. HSV-1 genome replication and encapsidation occurs in the nucleus, …
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An inducible, conditional and targeted B cell ablation mouse model for studying B cell functionality in the pathogenesis of human diseases
… ablation methods currently employed utilize the herpes simplex virus 1 thymidine kinase (HSVtk) or diphtheria toxin (DT) receptor combined with their respective transgenic strategies. The ablation using HSVtk transgenic mice eliminates dividing cells, but does not affect non-dividing cells. In …
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Studies of viral and cellular proteins involved in herpes simplex virus type-1 egress
The egress pathway of herpes simplex virus-1 (HSV-1) is a complicated process mediated by co-ordinated activity of several virus glycoproteins. The virions are first assembled and enveloped at trans-Golgi-network (TGN) or endosome membranes and then travel through a guided pathway that is directed …
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Molecular basis oh herpes simplex virus entry into the cell and retargeting of the viral tropism for the design of oncolytic herpesviruses
Herpes simplex virus 1 (HSV-1) infects oral epitelial cells, then spreads to the nerve endings and estabilishes latency in sensory ganglia, from where it may, or may not reactivate. Diseases caused by virus reactivation include mild diseases such as muco-cutaneous lesions, and more severe, and even …
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Understanding the function and structure of herpes simplex virus type 1 pUL55, a novel immune evasion protein
Herpes simplex virus-1 (HSV-1) infects approximately 67% of the human population, causing disease ranging from asymptomatic to severe. The virus affects individuals around the world, and results in lifelong infection. This work focusses on pUL55, a HSV-1 tegument protein, which we hypothesised to …
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