Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 125 for “"Herpes Simplex Virus"”.
-
PROTEASOME-DEPENDENT ENTRY OF HERPES SIMPLEX VIRUS
Herpes simplex virus entry into cells is a multistep process that engages the host cell machinery. The proteasome is a large, ATP-dependent, multisubunit protease that plays a critical role in the maintenance of cell homeostasis. A battery of assays were used to demonstrate that proteasome …
-
Transcription of herpes simplex virus type 2
Summary available: p. i-iv.
-
Purification of glycoproteins from herpes simplex virus
… was to purify type-specific glycoproteins from herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) for diagnostic use. The most likely candidate for a type-specific glycoprotein of HSV-1 is glycoprotein C (gC), although it has recently been shown to contain some type-common antigenic …
-
Cytomegalovirus and herpes simplex virus infections in pregnancy
Contains fulltext : 146799.pdf (Publisher’s version ) (Open Access)
-
Mechanisms of cell adhesion regulation by herpes simplex virus
Herpes simplex virus (HSV)-1 is a highly prevalent human pathogen that establishes a life-long infection. HSV-1 promotes its replication and spread by expressing multi-functional proteins that extensively remodel the host cell. Three such proteins are pUL21, pUL7 and pUL51. pUL21 is a viral …
-
Glycoprotein M and ESCRT in herpes simplex virus type 1 assembly
Herpes simplex virus type 1 (HSV-1) has a large linear double-stranded DNA genome in an icosahedral capsid shell, a cell-derived lipid envelope and a proteinaceous tegument layer. There are over fifty viral proteins and many host proteins identified in HSV-1 virions. The final formation of mature …
-
Analysis of heparan sulfate function during herpes simplex virus type-1 infection.
Analysis of heparan sulfate function during herpes simplex virus type-1 infection.
-
Gene regulation and function of ICP0 in herpes simplex virus infected cells
Herpes simplex virus (HSV) is a clinically important virus, whose life cycle alternates between productive replication and latency. Infected cell protein 0 (ICP0) is generally believed to play a key role in determining the outcome of HSV infections. Synthesis of ICP0 promotes the productive …
-
Immunevasion von Herpes-simplex-Virus Typ 1: Angriff auf Zellen des Immunsystems
… Anwesenheit von Acyclovir, einem Inhibitor der herpesviralen DNA-Replikation, gehemmt werden konnte. Letztendlich war der zugrundeliegende Mechanismus zelltypspezifisch, da andere Zellen des Immunsystems, die mit HSV-1 infiziert wurden, unveränderte c-FLIP(L)-Mengen zeigten. Die hier …
-
The production, harvest and adsorptive recovery of an infectious herpes simplex virus vaccine
… present there is not a reliable vaccine against herpes virus. Viral protein vaccines as yet have proved unsuccessful to meet the challenge of raising an appropriate immune response. Cantab Pharmaceuticals has produced a virus vaccine that can undergo one round of replication in the recipient in …
-
The role of autonomic neurons in the pathegenesis of herpes simplex virus infection
Herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) are major human pathogens. HSV establishes latency in the nervous system and reactivates to cause recurrent disease, resulting in transmission of progeny virions to naïve individuals. Though HSV-1 and HSV-2 share similar structure and genes, they …
-
Differential regulation of herpes simplex virus-1 and herpes simplex virus-2 during latency and post reactivation in response to stress hormones and nerve trauma in primary adult sensory and sympathetic neurons
The contrasting infection strategy of herpes simplex virus (HSV) consists of an initial primary lytic infection in epithelial cells, followed by establishment of lifelong latency in sensory and autonomic neurons of the peripheral nervous system that innervate the site of infection. Any cellular …
-
The role of the herpes simplex virus type 1 UL33 protein in DNA packaging
The UL33 gene of herpes simplex virus type 1 (HSV-1) encodes a 130 amino acid (aa) protein that is essential for the cleavage of concatemeric viral DNA into monomeric genomes and their packaging into preformed capsids. Several lines of evidence have suggested that UL33, along with the UL15 and UL28 …
-
Studies of viral and cellular proteins involved in herpes simplex virus type-1 egress
The egress pathway of herpes simplex virus-1 (HSV-1) is a complicated process mediated by co-ordinated activity of several virus glycoproteins. The virions are first assembled and enveloped at trans-Golgi-network (TGN) or endosome membranes and then travel through a guided pathway that is directed …
-
Molecular analysis of herpes simplex virus type 1 latency in experimentally infected mice / Barry Slobedman.
The aims of this study are to determine whether latent HSV genomes are a result of viral DNA amplification in the PNS during the establishment phase and to investigate the relationship between HSV DNA copy number and viral transcriptional activity during latent infection of the PNS. In order to map …
-
Ubiquitin Targets and Molecular Mechanisms of Herpes Simplex Virus 1 Infection in Adult Sensory Neurons
Herpes simplex virus 1 (HSV-1) is a double-stranded DNA virus, often acquired during childhood, that currently infects more than 50% of the human population. The symptoms of infection are herpetic lesions that frequently appear throughout a host's life in response to stress in the orofacial or …
Page 1 of 7