Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Heregulin"”.
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Effects of Heregulin on Muscle: A Biochemical and Histological Analysis
… leading to progressive muscular dystrophy. Heregulin/neuregulin-1 (HRG), a member of the epidermal growth factor family has been shown to induce neuromuscular junction (NMJ) gene expression in vitro and improve skeletal muscle function in dystrophic mice. However, it is unclear if the HRG …
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The role of EGFR, HER 2-4, heregulin and downstream signalling in prostate adenocarcinoma
… HER2/HER4 as positively prognostic in HSPC. Heregulin (HRG), a principle HER family ligand, has previously been noted to have a differential effect on HSPC (decreased proliferation) and HRPC (increased proliferation) cell lines. This study determines influence of HER family and HRG in a …
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The regulation of RANK and RANKL mRNA expression through activation of the JAK2/STAT5a pathway in human breast cancer cell lines ©
… (PRL), epidermal growth factor (EGF) and heregulin-beta1 (HRG-1), all known to activate STAT5a and play a role in breast cancer progression. This study shows that RANKL expression is upregulated by PRL, EGF and HRG-1, and that PRL and HRG-1 regulate transcription through the JAK/STAT5a …
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Analysis of biological and chemical systems using information theoretic approximations
… across multiple conditions (varying EGF or heregulin stimulation, and HER2 expression). This subset is shown to produce statistical models with superior performance to those built with subsets of similar size. We also employ the framework to extract configurational entropies from molecular …
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The Roles of Malt1 In Nf-Κb Activation and Solid Tumor Progression
… receptor (EGFR)-induced NF-κB in lung cancer and heregulin receptor (HER2)-induced NF-κB in breast cancer. We found that Mucosa-associated lymphoma translocation protein 1 (MALT1), also known as paracaspase, is required for EGFR-induced NF-κB activation by recruiting E3 ligase TRAF6 to the IKK …
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The Role of Tyrosine Phosphorylation In The Functions of The Tumor Suppressor Gprc5A
… (HMECs) with epidermal growth factor (EGF) or Heregulin. This suggested that GPRC5A is a substrate of EGFR. Therefore, we hypothesized that tyrosine phosphorylation of GPRC5A by activation of EGFR signaling may lead to its inactivation. To test this hypothesis, we transfected human embryo …
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Modeling Brk/PTK6 expression in the mammary epithelium.
… and notably, p38 MAPK in response to EGF and heregulin-β1 treatment. These studies illustrate that forced expression of Brk/PTK6 in non-transformed mammary epithelial cells in vivo mediates STAT5 and p38 MAPK phosphorylation and promotes increased cellular survival, delayed involution, and …
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Spatial Stochastic Modeling of the ErbB Receptor Family
… we show in the presence of erbB2 and heregulin, erbB3 has measurable kinase activity. Using the reconstructed domains from erbB2 and erbB3 data to create a simulation space, and experimental data from the kinase assay and single particle tracking, we extend the erbB1 spatial stochastic …
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Estradiol regulation of leucine-rich repeat immunoglobulin-like domains protein 1 (LRIG 1) and roles of estrogen receptor in translational regulation in breast cancer cells
… α (ERα), the Progesterone Receptor (PR) and Heregulin 2 (HER2). The ER, though often considered responsible for driving tumor growth, is usually indicative of a good prognosis as ER-positive tumors are typically more indolent in nature and responsive to endocrine therapy. Long after estrogens …