Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Hereditary Breast and Ovarian Cancer"”.
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Managing Susceptibility to Hereditary Breast and Ovarian Cancer
The recent identification of Breast Cancer 1 (BRCA1) and BRCA2 genes offers an opportunity for high-risk individuals to learn whether they may be genetically predisposed to develop breast and/or ovarian cancer. The purpose of this study was to examine how unaffected women, identified as BRCA …
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Evaluating The Nccn Clinical Criteria For Hereditary Breast and Ovarian Cancer Syndrome Genetic Testing
<p>Hereditary Breast and Ovarian Cancer (HBOC) syndrome predisposes females with a <em>BRCA1</em> or <em>BRCA2</em> mutation to an up to 85% lifetime risk for breast cancer and an up to 40% lifetime risk for ovarian cancer. It is crucial for individuals with HBOC to be identified to allow for …
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Perspectives and Experiences of Individuals Undergoing Predictive Testing for Hereditary Breast and Ovarian Cancer (HBOC) Syndrome in the Western Cape, South Africa.
Breast cancer is the most common malignancy affecting females globally. Hereditary breast and ovarian cancer (HBOC) syndrome is caused by pathogenic variants in BRCA1 and BRCA2 and is seen in approximately 50% of families with a strong history of breast and ovarian cancers. Predictive testing (PT) …
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Cancers Associated With Brca1 and Brca2 Mutations Other Than Breast and Ovarian
<p>Mutations in <em>BRCA1</em> and <em>BRCA2</em> cause tumor development in Hereditary Breast and Ovarian Cancer syndrome (HBOC) through accumulation of unrepaired DNA damage. Extensive research of <em>BRCA1</em> and <em>BRCA2</em> mutations has led to well-defined breast and ovarian cancer risks …
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Breast Cancer Risk For Female Relatives of Male Breast Cancer Patients With Negative Brca1/2 Testing
… exist to estimate a female’s lifetime risk of breast cancer in the absence of a hereditary predisposition to cancer, namely Hereditary Breast and Ovarian Cancer syndrome. These risk models consider various factors such as reproductive history and family history, but few models take a family …
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Blame it on her genes : on performativity, politics, and the consumption of prevention
… thesis examines the politics of performativity and its effects in everyday life. The context of the study is the practices surrounding the consumption of preventive solutions for hereditary breast and ovarian cancer, and a specific set of genes, the BRCA genes, which are associated with an …
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Predictors of Contralateral Breast Cancer In Brca Negative Women
<p>Breast cancer is the most common cancer diagnosis and second leading cause of death in women. Risk factors associated with breast cancer include: increased age, alcohol consumption, cigarette smoking, white race, physical inactivity, benign breast conditions, reproductive and hormonal factors, …
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Knowledge, Attitudes, and Utilization of Brca Testing Among Obstetricians and Gynecologists
<p>Hereditary breast and ovarian cancer (HBOC) is an inherited cancer syndrome that is associated with mutations in the <em>BRCA1</em> and <em>BRCA2</em> genes. Carriers of <em>BRCA</em> mutations, both men and women, are at an increased risk for developing certain cancers. Carriers are most …
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Factors Associated With Early Versus Late Development of Breast and Ovarian Cancer In Brca1 and Brca2 Positive Women
Hereditary breast and ovarian cancer (HBOC) is caused by a mutation in the BRCA1 or BRCA2 genes. Women with a BRCA1/2 mutation are at increased risks for breast and ovarian cancer and often develop cancer at an earlier age than the general population. However, some women with a BRCA1/2 mutation do …
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Accuracy of The Brcapro Risk Assessment Model In Males Presenting to Md Anderson For Brca Testing
… RISK ASSESSMENT MODEL IN MALES PRESENTING TO MD ANDERSON FOR<em> BRCA</em> TESTING</p> <p>Publication No. _______</p> <p>Carolyn A. Garby, B.S.</p> <p>Supervisory Professor: Banu Arun, M.D.</p> <p>Hereditary Breast and Ovarian Cancer (HBOC) syndrome is due to mutations in <em>BRCA1</em> and …
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Genetic factors in childhood cancer. Associations between tumors in childhood and adulthood, and prevalence of germline TP53 mutations
The etiology of childhood cancer is largely unknown. Approximately 1-10% of all childhood tumors are associated with known cancer predisposition syndromes. However, the contribution may be underestimated due to the failure to detect patients with genetic susceptibility for cancer when relying on …
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Assessing the Clinical Relevance of BRCA1 BRCT Domain Variants of Uncertain Significance
Breast and ovarian cancer are among the most common cancers in Canadian women. Approximately 5-10% of breast and 20-25% of ovarian cancers are inherited, with pathogenic germline BRCA1 and BRCA2 variants causing the majority of hereditary cases. While genetic testing is used to identify pathogenic …
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Factors Influencing Uptake of Risk-Reducing Salpingo-Oophorectomy By Brca1 and Brca2 Mutation Carriers
<p>Germline mutations in the <em>BRCA1</em> and <em>BRCA2</em> genes are associated with significantly increased risks for ovarian cancer. The National Comprehensive Cancer Network (NCCN) currently recommends that female BRCA mutation carriers undergo risk-reducing salpingo-oophorectomy (RRSO) …
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Cancer Incidence In First and Second Degree Relatives of Brca1 and Brca2 Mutation Carriers
… genes are associated with increased risks for breast, ovarian, and several other cancers. The purpose of this study was to evaluate the incidence of cancers in first and second degree relatives of <em>BRCA</em> mutation carriers compared to the general population. A total of 1086 pedigrees of …