Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"Herceptin"”.
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The role of receptor tyrosine kinase signalling in HER-2-positive cells and trastuzumab (Herceptin) resistance in breast cancer
HER-2 gene amplification or overexpression occurs in approximately 25 % of breast cancers, and trastuzumab (Tmab) is a monoclonal antibody currently used to treat patients with HER-2-overexpressing breast cancer. Signalling through alternative receptor tyrosine kinases, such as insulin-like growth …
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Optimierung des Chemosensitivitätstests ChemoSelect und Untersuchung der Möglichkeit des Nachweises einer Wirkung des monoklonalen Antikörpers Herceptin in diesem diagnostischen Testverfahren
… Therapeutikum wurde der monoklonale Antikörper Herceptin verwendet, der gegen den Her2/neu Rezeptor gerichtet ist. Im Testsystem ließ sich eine Wirkung des monoklonalen Antikörpers sowohl als Monotherapeutikum als auch in Kombination mit Chemotherapie nachweisen. Dieser Effekt war spezifisch bei …
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Improving Medicare & Medicaid Reimbursement Framework for Molecular Diagnostics Tests Using Gene Sequencing: A Case Study in Health Economics
… cell surface, which can be treated with the drug Herceptin, or trastuzumab, improving cancer free survival rates from 71.9% to 84.2% in five years. However, in spite of the observed increase in survival rates, the question of economic value produced by adding Herceptin to the chemotherapy remains …
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Y-box binding protein-1 (YB-1) is essential for the growth and survival of HER-2 over-expressing breast cancer cells
… addressed whether it could play a part in Herceptin sensitivity. Herceptin is currently being used to treat patients with HER-2 positive breast cancer; however, only 30% of the patients respond to the therapy and many of them develop resistance within the first year of treatment. Therefore, …
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Personalized medicine, population genetics and privacy : an empirical study of international gene banks
… in disease and metabolic pathways. Drugs like Herceptin, Gleevec and Iressa are part of an emerging trend in the biopharmaceutical arena of drugs that are accompanied by genetic diagnostic tests and prescribed only for patients with genotypes in which the agents are most effective.
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Localized and disease-selective drug delivery using adhesive hydrogels for treatment of locally advanced TNBC
… common endocrine treatment such as tamoxifen or Herceptin. Systemic neoadjuvant therapy has been established as the preferred therapeutic approach for locally advanced breast cancer, downstaging the disease and preventing mastectomy. However, complications of systemic chemotherapy are …
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Assembly, characterization and evaluation of a 3rd generation nanoparticle based drug carrier for metastatic breast cancer treatment
… and controlled release. Anti-Her2 antibody or Herceptin® was grafted onto the surface of the liposome for a higher affinity to the Her2 overexpressing breast cancer cells. Firstly, the conjugation of protein to the surface of liposome and PEGylated liposomes were investigated. Proteins with or …
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Jab1 Negatively Regulates Pten and Promotes Resistance to Trastuzumab In Her2-Positive Breast Cancer
… 20% of all breast cancer cases. Trastuzumab (Herceptin), the first targeted therapy approved for HER2-positive disease, potently prevents the activation of signaling pathways downstream of HER2 and significantly improves patients’ outcomes. However, resistance to trastuzumab is inevitable; …
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Influence of missing explanatory variables and longitudinal assessments in breast cancer clinical trials
… Study Group (IBCSG) Trials VI and VII and the Herceptin Adjuvant (HERA) trial. Both investigated adjuvant treatment in breast cancer. There was no evidence in Trials VI and VII that the patient's QoL is related to the patient's DFS, though such a relationship could be masked by the missing …
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Semiconductor nanocrystals for novel optical applications
… CdSe/ZnS quantum dots interacted with CPP and Herceptin to apply them as a bio-maker. Both of quantum dots showed the excellent potential for use in biomedical imaging and drug delivery applications. It is anticipated that these approaches can play a significant role in the eventual …
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Fulfilling the promise of targeted therapeutics in oncology via companion diagnostics : a perspective on pipeline trends and co-development strategies
Herceptin was the poster child of personalized medicine that brought forward the notion that contemporaneously developed companion diagnostics (CDx) could lead to more efficacious use of a cancer therapeutic in a selected population. Despite a gap of 12 years, the recent approvals of Zelboraf and …
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Investigating the plasmonic behaviour of gold nanostructured arrays with finite element method modelling for optical sensing applications
… A and G from common bacteria and Trastuzumab (Herceptin), a breast cancer drug. Generally, the calculated kinetic coefficients were in good agreement with published values. <br/><br/>To improve sensitivity and uniformity of the chips, the effect of surface parameters, such as diameter, height …
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Development of an Approach to Increase Drug Uptake to Bone Tumors Using Non-Invasive Mechanical Loading
… as controls, 5) use of the clinically relevant Herceptin as the injected drug, and 6) implementation of high-resolution microCT and histology to assess bone destruction from tumor growth. If additional studies in the rat model using these improved techniques demonstrate load-induced enhancement …
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Monoclonal Antibody Expression and Novel Purification in Nicotiana benthamiana
… antibodies such as Avastin (bevacizumab), Herceptin (trastuzumab), Rituxan (rituximab), Humira (adalimumab) and Remicade (infliximab), which are cornerstones in this type of sector. With the cost of development to market approval rising astronomically for a new drug, new ways to produce and …
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Immune responses in primary and metastatic breast cancer
… major developments most notably in the form of Herceptin. Current evidence suggests that the immune system is stimulated by tumours to manifest a response. Many breast cancers show evidence of this immune response in the form of tumour infiltrating lymphocytes. However contradictory opinions …
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SMART POLYMERIC DRUG NANOCARRIERS FOR BIOMEDICAL APPLICATIONS
… of nanoparticles towards breast cancer cells, Herceptin, a monoclonal antibody able to selectively recognize a specific receptor (HER2) over- expressed on 25-30% of invasive breast cancer, was attached to the surface of the carriers by hydrophilic/hydrophobic interactions. Surface coating was …
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Identification of novel biomarkers and therapeutic strategies in triple negative breast cancer
… with targeted therapies such as Tamoxifen and Herceptin which are often used in breast cancer. Thus, the current standard of care (SoC) for these patients is cytotoxic chemotherapy (often DNA damaging agents +/- anti-microtubule agents) with some patients responding well while others derive no …