Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Her4"”.
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Her4 Promotes A Stem-Like Phenotype In Osteosarcoma
… modulators of the stem-like phenotype.</p> <p>Her4, a transmembrane receptor of the EGFR family, has been recently studied for its role in cancer. Previously, we demonstrated that Her4 is highly expressed in neuroblastoma, and OS, while others have shown its importance in Ewing sarcoma. This …
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The role of EGFR, HER 2-4, heregulin and downstream signalling in prostate adenocarcinoma
… tyrosine kinase family - EGFR, HER2, HER3 and HER4 - during disease progression in prostate adenocarcinoma is conflicting – both poor prognosis and no influence on outcome are reported. A small cohort pilot study of paired hormone sensitive (HSPC) and refractory (HRPC) specimens demonstrated …
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Design and development of novel tools for the screening and identification of inhibitors of HER receptor family and NFR2 for ovarian cancer therapy
… the expression of HER family receptors, HER1 and HER4, elevates phospho protein kinase B (pAKT) levels, and enhances the proliferation of ovarian cancer cells. Pharmacological inhibition using retinoic acid (RA) and bexarotene and genetic inhibition using small interfering RNA (siRNA), did the …
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Expression of Epidermal Growth Factor Receptor in hypopharyngeal cancer and Effect of EGF in Progression of hypopharyngeal cancer
… includes HER2/neu (erbB2), HER3 (erbB3), and HER4 (erbB4). High levels of EGFR expression are correlated with poor prognosis and resistance to radiation therapy in a variety of cancers, mostly in head and neck squamous cell carcinoma (HNSCC). So we examined the expression of EGFR in …
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Modulating cell behavior with engineered HER-receptor ligands
… factor receptor (EGFR or HERI), HER2, HER3 and HER4 - influence processes as diverse as development, wound healing, migration, and tissue homeostasis and family members are expressed by almost every cell type. All HER receptors require either homodimerization or heterodimerization with other …
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Axogial communication mediated by soluble neuregulin-1 and bdnf
… human epidermal growth factor receptor 4 (HER4). This fusion protein retains high affinity for heparin binding and to specific cell surface that express heparan sulfates resulting in a much more potent NRG1 antagonist than any other inhibitors for this molecule. In vivo, it is targeted to …
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Characterization of Erbb4 Expression In Osteosarcoma
<p>ERBB4 (Her-4) is a member of the ERBB family of Class I receptor tyrosine kinases. ERBB4 is unique within the ERBB family for alternate splicing in its juxtamembrane and cytoplasmic regions, which produces four juxtamembrane isoforms and two cytoplasmic isoforms. The cleavable juxtamembrane …
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Development and Evaluation of Novel Anti-HER2 Theranostics Against HER2-Positive Breast Cancer
… or other HER family members (HER1/EGFR, HER3 and HER4), initiating downstream signalling pathways that regulate the proliferation, differentiation and growth of cancer cells. In the past 20 years, remarkable advancements have been achieved in developing treatments against HER2-positive BC. One of …