Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 45 for “"Her-2"”.
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Treatment outcomes of Her-2 positive Breast Cancer in the absence of Her-2 targeting agents at Groote Schuur Hospital, Cape Town, South Africa. Are we doing enough?
… in Sub-Saharan Africa. The addition of anti- Her-2 targeted therapy (Trastuzumab) to either adjuvant or neo-adjuvant treatment significantly improves disease-free survival and overall survival of women with early-stage Her-2 positive breast cancer. However, at Groote Schuur Hospital anti-Her-2 …
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Expressão de HER-2/neu e p53 em adenocarcinoma de esôfago e cárdia
… de estudos da patogênese destes tumores. HER-2/neu é um oncogene expresso in diversas neoplasias e relacionado à pior prognóstico. P53 é igualmente importante estando mutado em 50%-70% das neoplasias sólidas com implicações clínicas para muitos tumores. Este trabalho determina a frequência …
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Bedeutung des Her-2/neu beim Ovarialkarzinom - Korrelation und Vergleich mit klinischen Prognosefaktoren
… wird eine immunhistochemische Bestimmung des Her-2/neu - Status vorgenommen, der beim Mamma-Karzinom als unabhängiger Prognosefaktor bekannt ist und mit einer schlechteren Prognose einhergeht. Zusammenfassend ließ sich in dieser Arbeit keine Überexpression des Her-2/neu am Ovar feststellen, …
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Ανάπτυξη και αξιολόγηση συστημάτων χορήγησης πεπτιδικών αντιγόνων HER-2/neu συνδεδεμένων με PLA μικροσφαίρες
… Από τα γνωστά καρκινικά αντιγόνα, η πρωτεΐνη HER-2/neu παρουσιάζει το πλεονέκτημα της υπερέκφρασης σε ποικίλους τύπους καρκίνου, ενώ οι ασθενείς των οποίων όγκοι την υπερεκφράζουν παρουσιάζουν προϋπάρχουσα ανοσία ενάντια σε πεπτίδια αυτής. Η αυξημένη έκφρασή της στα καρκινικά κύτταρα και το …
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The role of EGFR, HER 2-4, heregulin and downstream signalling in prostate adenocarcinoma
… Currently evidence regarding influence of the HER tyrosine kinase family - EGFR, HER2, HER3 and HER4 - during disease progression in prostate adenocarcinoma is conflicting – both poor prognosis and no influence on outcome are reported. A small cohort pilot study of paired hormone sensitive …
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Evaluation of the P13K pathway and downstream effect in Her-2 positive and negative breast carcinomas
… in gene expression. Several components of the Her-2/PI3K/Akt pathway were evaluated for their relevance as potential prognostic markers or indicators for treatment. A secondary objective was to evaluate the CISH technique for its suitability for analysis of Her-2 gene amplification on archived, …
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The role of receptor tyrosine kinase signalling in HER-2-positive cells and trastuzumab (Herceptin) resistance in breast cancer
HER-2 gene amplification or overexpression occurs in approximately 25 % of breast cancers, and trastuzumab (Tmab) is a monoclonal antibody currently used to treat patients with HER-2-overexpressing breast cancer. Signalling through alternative receptor tyrosine kinases, such as insulin-like growth …
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Y-box binding protein-1 (YB-1) is essential for the growth and survival of HER-2 over-expressing breast cancer cells
The human epidermal growth factor receptor (HER-2) is over-expressed in 20-30% of breast carcinomas and is a prognostic marker for poor patient outcome. We previously identified the transcription/translation factor Y-box binding protein-1 (YB-1) to be a novel substrate of AKT which binds to …
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The effects of Low α-Linolenic fatty acid Soybean Oil and Mid Oleic acid Soybean Oil on the growth of Her-2/neu and Fatty acid synthase over-expressing human breast cancer (SK-Br3) cells
… ratio are known to influence BC development. Therefore, it is possible that the changed FA composition and n-6/n-3 ratio in the FA modified SOs may affect BC progression, and its critical health concern needs to be investigated. Increased human epithelial growth factor receptor 2 (Her-2/neu) …
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Use of Kinase Inhibitors to Illuminate Signaling Pathways in Breast Cancer
… epidermal growth factor receptor 2 positive (HER-2+). HER-2 is a protein receptor located on the cell surface that interacts with other proteins and signaling molecules to translate extracellular signals into cellular process such as cell growth and replication. However, in breast cancer, …
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Hormonal modulation of sex steroid hormone receptors and oncogenes in human breast cancer cells
… breast tumor growth, and high levels of the HER-2/neu protooncogene protein may contribute to breast cancer metastasis, the effects of estrogen, progestin and hormone antagonists on the levels of estrogen receptor (ER), progesterone receptor (PR) and HER-2/neu mRNA and protein have been …
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Studio di nuovi approcci farmacologici in grado di inibire l'attivazione dei recettori del fattore di crescita epidermico (EGF) in linee cellulari di carcinoma polmonare non a piccole cellule (NSCLC)
… del blocco di due recettori dell EGF, EGFR e HER-2, sulla proliferazione delle cellule A549 e NCI-H226 di carcinoma polmonare. Sono stati utilizzati, a tale scopo, cetuximab, anticorpo monoclonale diretto contro l'EGFR e trastuzumab, anticorpo monoclonale diretto contro l'HER-2, a diverse …
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Breast Cancer Specimen Collection, Handling & Adherence to ASCO/CAP Guidelines
… Cancer Specimen Collection, Handling & Adherence to ASCO/CAP Guidelines</p> <p><strong>Background</strong></p> <p>Specimens removed from their blood supply begin to degrade immediately. Specimens are placed in formalin to halt the process of degradation. Under or over-exposure of specimens …
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ESPRESSIONE DI SEL1L NEL CARCINOMA MAMMARIO - CORRELAZIONI CLINICO PATOLOGICHE
… may be important in determining the successive therapeutic approach. In patients of Black African ethnicity, breast cancer strongly differ from Western populations in ethnicity, lifestyle and environmental exposures and is reportedly to be characterized by aggressive, poorly differentiated …
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SILVER NANOPARTICLES ARE EFFECTIVE FOR THE TREATMENT OF CLAUDIN LOW BREAST CANCER AND OTHER MESENCHYMAL CANCERS WITH HIGH ZEB1 EXPRESSION
… into 5 molecular subtypes (luminal A, luminal B, HER-2 overexpressing, basal-like, and claudin-low) that have distinct genetic aberrations, morphological features, prognoses, and therapeutic responses. Therefore, breast cancer should be treated with subtype specific therapies as these may provide …
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Tyrosine Kinase Inhibitors in Triple Negative Breast Cancer
… and progesterone receptor expression and HER-2 amplification (‘triple negative’ breast cancer, TNBC), and express basal cytokeratins 5/6, and EGFR (epidermal growth factor receptor). No targeted therapy options are currently approved for this subgroup of patients. The main aim of this …
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Tumor infiltrierende dendritische Zellen im Adenokarzinom des Uterus : eine Studie von 115 Neoplasien mit Korrelation zu anderen Prognosefaktoren und zur Überlebensrate
… Neoplasie des weiblichen Genitales. Trotz guter Therapieerfolge und deutlich verbesserter Früherkennungsrate liegt die relative 5-JÜR im Stadium 4 bei unter 16%. Zur Wahl einer möglichst individuell angepassten Therapie ist es wichtig die Prognose möglichst gut einschätzen zu können, hierzu dienen …
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$2 cheesecake death.
… year old girl, Amy Brugger, who finds herself trapped in a life she never wanted. She works as a telemarketer and she is one in a room of a hundred others just like her. Suddenly, without trying too hard, she discovers an opening at the law offices of Weisenhauer, Alistair, and Freeman. …
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