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Showing 1 to 17 of 17 for “"Hepcidin"”.
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The regulation of the hepcidin by modulators of the bone morphogenetic protein (BMP) pathway
Hepcidin, the iron regulatory peptide, has emerged as the master regulator of systemic iron homeostasis. Under normal circumstances, hepcidin expression is upregulated by excess iron and inflammation; and downregulated by iron deficiency, anaemia and hypoxia. Insights gained into the pathogenesis …
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Molecular and cellular insights into iron regulation
The iron hormone hepcidin is regarded as the main iron homeostatic regulator in the human body. It is predominantly produced by hepatocytes in response to systemic iron excess. However, since the cellular and molecular mechanisms involved in hepcidin expression are not fully understood, this …
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The regulation of human iron metabolism in hypoxia
… interleukin-6 (IL-6) production and elevated hepcidin production 3 h thereafter in both normoxia (fraction of inspired oxygen (FIO2) = 0.2093) and normobaric hypoxia (i.e. 3,000 m simulated altitude; FIO2 = 0.1450). These results suggest exercise performed in acute hypoxia does not alter the …
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Novel insights into the interaction between iron and curcumin and its physiological consequences
… as intense endurance exercise upregulates hepcidin, the master regulator of iron homeostasis that restrains intestinal iron absorption and causes GI adverse events. Co-administration of ferrous iron with curcumin, a polyphenol from turmeric root, might ameliorate oral iron- and …
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Development and validation of quantitative methods for the analysis of clinical biomarkers of iron metabolism applying stable isotopes
… 2001, a liver-synthesized peptide hormone called hepcidin-25, present in biological fluids in the ng ml-1 range, was discovered. Despite its present importance, there is currently a lack of analytical methodologies validated for determination of this putative biomarker to the point of enabling its …
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Comparison of expression pattern and localization of iron transport proteins in rat liver, brain and spleen during acute phase response:invivo and invitro studies
… hephastin-Gene eine schnelle Abnahme. Hepcidin, DMT-1, Transferrin und TfR1, TFR2, Ferritin H und L-Ferritin-Gen-Expression wurde erhöht. Immunobloting bestätigt die Änderungen auf mRNA beobachtet, was auf eine Zunahme der Proteinmenge aus Eisen Einführer (Tf, TfR1, TFR2 und DMT-1) und …
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A role for iron in oesophageal adenocarcinoma
… disease progression. Interestingly expression of hepcidin, the hepatic peptide responsible for systemic control of iron, was identified in samples of OAC. Culturing OAC cells with iron or haem increased cell proliferation, migration and anchorage independent growth. These effects were inhibited by …
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In vitro effects of different innate-immune stimulants on Chinook salmon embryo cell line (CHSE-214): transcriptional and translational studies
… expression of innate effectors: cathelicidin, hepcidin, iNOS, MDA5, RIG-I and ISG25 mRNA was assessed by qPCR in Chinook salmon cell line (CHSE-214) before and after treatment with potential inducers: ß-hydroxy-ß-methylbutyrate, 4-phenylbutyrate, 1,25(OH)2 D3, omega-3 and omega-3 ethyl ester …
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Molecular responses of iron regulatory proteins to iron overload in human liver
… level of control for both molecules. Hepcidin has recently been dubbed as the main regulator of dietary iron absorption and levels of the transcript in the liver of HH patients failed to respond to the extent of the iron burden, pointing to a central role of this molecule in the …
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Primary Myelofibrosis, Post-Erythremia Vera and Post- Essential Thrombocythemia Myelofibrosis - Impact of Inflammatory Cytokines (Interleukin 6, Interleukin 8) and Regulators of Iron Metabolism (Hepcidin) in The Pathogenesis of Anemic Syndrome // Първична, пост-еритремична, пост-тромбоцитемична миелофиброза - участието на инфламаторни цитокини (interleukin 6, interleukin 8) и регулаторите на железния метаболизъм (хепсидин) в патогенезата на анемичния синдром
Миелофиброзата (МФ) е клонална хематологична неоплазия с хетерогенна клинична изява, прояви на фибротично заместване на кръвотворенето, костно-мозъчна недостатъчност, екстрамедуларна хемопоеза, ексцесивна спленомегалия и наличие на тежък анемичен синдром. Подозиран фактор в развитието на анемия при …
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Iron-induced Complement Dysregulation in the Retinal Pigment Epithelium: Implications for Age-Related Macular Degeneration
… Bmp6 KO mice and WT mice and found that retinal hepcidin levels are not changed, but in fact may be slightly greater in KO compared to WT mice. As such, systemic iron overload by genetic KO or intravenous supplementation in WT mice resulted in increased RPE labile iron and oxidative stress, …
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Identification of a novel method for differentiating human monocytic cell line into macrophages
… effects of activated macrophages in inducing hepcidin expression in HUH7 cells, by investigating the signals transferred by EVs between the two cells. Moreover, this research can provide the basis for uncovering mechanisms of communication between the THP-1 and HUH7 cells for cancer diagnosis, …
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The effects of quercetin on iron metabolism
… of FPN.<br/>In HepG2 cells quercetin stimulated hepcidin expression and inhibited ferroportin gene expression; this may provide an additional means of regulating systemic iron levels. Quercetin was shown to be both pro- and anti- proliferative/apoptotic dependent on the concentration used which …