Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"Hepatoxicity."”.
-
Nonalcoholic steatohepatitis (NASH) : animal studies of interactive hepatoxicity
The term "Nonalcoholic steatohepatitis" (NASH) describes a form of liver disease indistinguishable from alcoholic liver disease, but present in persons who consume insignificant amounts of alcohol. The spectrum of non-alcoholic liver disease ranges from non-progressive steatosis, through to NASH and …
-
The role of "non-alcoholic steatohepatitis (NASH)" in methotrexate induced liver injury
Hepatoxicity, especially liver fibrosis. is the major concern with long-term, low-dose oral methotrexate (MTX) therapy for psoriasis. The histological features are nonspecific and may resemble those of nonalcoholic steatohepatitis (NASH). Moreover most of the risk factors of MTX induced liver …
-
Impacts of Oil Exposure During Early Life Development Stages In Sheepshead Minnows (<i>Cyprinodon variegatus</i>) Under Different Environmental Factors
… cholesterol biosynthesis, cardiotoxicity, and hepatoxicity. These findings indicate that the post-larval stage is the most sensitive to oil and environmental stress.</p>
-
Understanding the transport mechanisms of BSEP to improve the prediction of DILI compounds
… DILI concerns predictable dose-dependent hepatoxicity, idiosyncratic DILI refers to unpredictable adverse drug reactions for which there is no existing pharmacological explanation. Many prescription and over-the-counter drugs causing DILI do so in an undiscovered and idiosyncratic pattern. …
-
The significance of OATP and CYP450 in statin-flavonoid interactions
Statins are the most prescribed drug world-wide as a first-line defence to hypercholesteraemia. In rare cases, statins can have adverse events such as myotoxicity which can further progress to a potentially fatal condition, rhabdomyolysis. This risk is exacerbated by drug-drug interactions between …
-
Do Elevated Levels of Glutathione Decrease the Toxicity of Plasticizers in Mouse Liver Cells?
Phthalates are esters of phthalic acid that play a crucial role in the manufacturing industries for enhancing the properties of plastic materials. Di-(2-ethylhexyl) phthalate (DEHP) is one of the most common phthalates used in a variety of products including food packaging and medical equipment. …