Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 309 for “"Hepatocytes"”.
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Toxicity of microcystin-LR in hepatocytes and non-hepatocytes in vitro
… toxic to the liver in vivo and isolated hepatocytes in vitro. Inhibition of PPs has been linked to excessive phosphorylation and collapse of intermediate filaments (IFs) in hepatocytes. MCLR was used as a probe to understand the mechanism of action of this toxin in hepatocytes and …
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Regulation of Cholesterol Biosynthesis in Hepatocytes
Hypercholesterolemia, a condition of high cholesterol levels in the circulation, poses a major risk for developing cardiovascular disease, such as atherosclerosis. A common method of reducing plasma cholesterol levels relies on the administration of drugs that limit cholesterol synthesis or uptake, …
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TRANSFORMATION OF PRIMARY HUMAN HEPATOCYTES IN HEPATOCELLULAR CARCINOMA
… knowledge of neoplastic transformation of hepatocytes in HCC. In clinical practice, the high rate of HCC local recurrence suggests the presence of different hepatocyte populations within the liver and particularly in the tumor proximity. This study aims to investigate primary human …
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HEPATOCYTES COORDINATE A SYSTEMIC ENDOCRINE NETWORK IN CANCER
… interleukin (IL)-6/STAT3 signaling in hepatocytes, regulates T cell surveillance and pro-metastatic conditioning in cancer and, ultimately, survival and response to standard of care therapies. We found that primary tumor development alters the liver microenvironment, marked by an …
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Characterization of Hepatitis C Virus Infection of Hepatocytes and Astrocytes
… transfer process. Lastly, HCV from HCV-infected hepatocytes and patient plasma occurred in both exosome-free and exosome-associated forms and the exosome-associated HCV remained infectious, even though HCV infection did not significantly alter exosome secretion. In the third chapter, we …
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Clonal proliferation of hepatocytes during chronic hepatitis B virus infection.
… remain unclear. We hypothesised that some hepatocytes lose HBV antigen expression and escape the HBVspecific immune response, allowing them to undergo clonal proliferation. Clonal proliferation of altered hepatocytes may be a marker of disease progression and may have a direct role in the …
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Development of a potential bioartificial liver : selective adhesion of hepatocytes
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1993.
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Synthetic Functionalized Scaffolds for Culture and Maintenance of Primary Human Hepatocytes
… molecules, we were able to culture primary human hepatocytes demonstrate their viability and maintenance of phenotype. The hydrogel material was formed by co-assembly in aqueous buffer and characterized using transmission electron microscopy (TEM), fluorescence analysis, and rheology. TEM was …
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Influence of mitochondrial membrane potential on the cryopreservation survival of hepatocytes
Hepatocytes are widely used in the pharmaceutical and medical fields for drug metabolism studies, bioartificial liver devices, and repopulation of damaged livers as an alternative to transplantation. However, these cells are scarce and difficult to maintain in culture for prolonged periods of time. …
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Induction and Regulation of CXCL10 in Hepatocytes During Hepatitis C Virus Infection
… I [RIG-I]) contribute to CXCL10 induction in hepatocytes. CXCL10 mRNA and protein were measured in primary human hepatocytes (PHH) and hepatocyte lines harboring functional or non-functional TLR3 and RIG-I pathways following HCV infection or exposure to receptor-specific stimuli. The …
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A Systems Approach to Studying the Differentiation of Stem Cells Towards Hepatocytes
… to become any specific cell type, such as hepatocytes. A robust and efficient process for expansion and differentiation to generate large quantities of functional hepatocytes from stem cells will be essential to establishing a stem cell bioprocess in the future for therapeutic and …
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Establishing the role of vitamin a production in hepatocytes in cardiometabolic diseases
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-12-01
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Production of hepatocytes from human pluripotent stem cells for cell-based therapy
… differentiate into diverse cell types, including hepatocytes. Thus, hPSCs allow for large-scale production of hepatocytes necessary for cell-based therapy. Importantly, cell-based therapy involving the transplantation of hepatocytes-like cells (HLCs) represent a promising alternative to liver …
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High-throughput approaches to sourcing of human hepatocytes for cell-based therapies
… the full functional capacity of primary adult hepatocytes, and for clinical applications there is a tumorigenic risk. Primary human hepatocytes have exhibited therapeutic potential; however, limited sourcing has been a bottleneck for many fields of research and clinical therapies. Pluripotent …
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Transcriptional profiling of rat primary hepatocytes cultured in a 3D microfabricated liver reactor
Thesis (M.Eng.)--Massachusetts Institute of Technology, Biological Engineering Division, 2003.
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Regulation of glucose -6 -phosphate dehydrogenase by polyunsaturated fatty acids in cultured rat hepatocytes
… or a posttranscriptional step in rat hepatocytes, enzyme activity, mRNA accumulation and transcriptional activity of the G6PD gene were measured in the presence and absence of a polyunsaturated fatty acid, arachidonic acid. Insulin and glucose stimulated a 5- to 7-fold increase in G6PD …
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Anoxia tolerant hepatocytes : a model system for the study of metabolic and channel arrest
… is a method for the isolation of anoxia tolerant hepatocytes from the freshwater turtle Chrysemys picta bellii. Freshly isolated hepatocytes were determined to be viable based on trypan blue exclusion, LDH leakage, gluconeogenic capacity from 14C-lactate and responsiveness to adrenalin, glucagon, …
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Co-culture of hepatocytes with mesenchymal stem cells for cellular therapy in liver disease
… practice is the marginal quality of isolated hepatocytes. Previous studies showed that mesenchymal stem cells (MSCs) could maintain morphology and improve liver-specific metabolism of co-cultured hepatocytes. The present work aimed to optimise the MSCs co-culture system by testing adipose …
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