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Showing 1 to 3 of 3 for “"Hepatocyte Nuclear Factor 4"”.

  1. The Role of HNF4A in Germ Cell Tumor Development

    … YST driver genes. We have determined that the Hepatocyte Nuclear Factor 4 alpha locus, which resides in this region, is frequently amplified in YSTs. Overexpression of HNF4A in an undifferentiated GCT line is sufficient to drive extraembryonic endodermal gene programs. This endodermal program …

    tdl Repository record for The Role of HNF4A in Germ Cell Tumor Development (opens in a new tab)

  2. Characterisation of the potentially diverse transcriptional regulatory mechanisms of human coagulation PZ gene.

    … in two evolutionarily related proteins, human factor IX and protein C. These regions were found to be bound specifically by potentially the same or a similar protein; but the identity of the protein could not be confirmed as either PEA3 or Ets1, although transactivation data from HepG2 cells …

    sheffield-hallam Repository record for Characterisation of the potentially diverse transcriptional regulatory mechanisms of human coagulation PZ gene. (opens in a new tab)

  3. Identification and Characterization of Transcriptional Regulatory Elements for Liver-Specific Expression of Rabbit CYP2C Genes

    … motif of a liver-enriched transcriptional factor hepatocyte nuclear factor 4 (HNF-4), since it was recognized by a nuclear protein with the same tissue distribution, DNA binding specificity and immunochemical reactivity as those of HNF-4. The CYP2C2 promoter-luciferase constructs containing …

    uiuc Repository record for Identification and Characterization of Transcriptional Regulatory Elements for Liver-Specific Expression of Rabbit CYP2C Genes (opens in a new tab)