Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"Hepatocyte Growth Factor (HGF)"”.
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Green Tea Polyphenol Epigallocatechin-3-gallate Inhibits Hepatocyte Growth Factor-Induced Tumor Cell Migration and Invasion In Vitro and In Vivo
" 간세포성장인자(hepatocyte growth factor,HGF)와 그 수용체인 Met의 과 활성화는 많은 종류의 종양의 발생과 진행에 관여하는 것으로 알려져 있다. 본 연구에서는 HGF/Met 신호전달체계를 효과적으로 억제하는 물질을 찾아보고자하였고 녹차의 성분 중 생체에 영향을 주는 중요한 polyphenol인 Epigallocathechin-3-gallate(EGCG)가 HGF/Met 신호체계를 효과적으로 억제할 수 있다는 것을 발견하였다. EGCG는 HGF에 의한 Met의 활성 방식이 autocrine이든 …
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Nuclear Translocation of Met Via Internet Mechanism
… in breast cancer cells. Here, we show that hepatocyte growth factor (HGF) as well as hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) can induce nuclear translocation of full-length MET holoreceptor via a membrane-bound vesicle transport mechanism in breast cancer cells. Our findings provide a …
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Chemotaxis of Central Nervous System-derived Tumor Cells within Controlled Microenvironments
… cells to external signaling of Epidermal Growth Factor (EGF), hepatocyte growth factor (HGF), platelet-derived growth factor (PDGF-BB), and the stromal cell-derived factors 1-alpha (SDF-1). Experiments utilized transwell assays and immunocytochemistry to identify receptor activation in MB …
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Epithelial Tubular Fusion, Measuring Interconnection, and the Quest for Solving the Continuity Problem
… of candidate effectors. One such candidate was hepatocyte growth factor (HGF), which has known roles in cell migration, tubulogenesis, and cell proliferation. Addition of HGF robustly induced interconnection of adjacent spheroids. The proliferative effect of HGF neither promoted nor inhibited …
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Met Inactivation by S-allylcysteine Suppresses Migration and Invasion of Nasopharyngeal Cancer Cells Induced by hepatocyte growth factor
… HONE1 treated with SAC (0, 10, 20, or 40 mM) and hepatocyte growth factor (HGF). This study showed that SAC could suppress the migration and invasion of HNE1 and HONE1 cell lines by inhibiting p-Met. An increase of migration and invasion induced by HGF and its decrease in a dose dependent manner …
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Birth Defect Amelioration and Placental Cytokine Expression in Mnu-Exposed Dams Treated With Ifn-Gamma
… gene microarray studies were conducted. Hepatocyte growth factor (HGF), interleukin 1 beta (IL1Β), and insulin-like growth factor 2 (IGF2) were elucidated as genes that were significantly expressed in GD12 placenta. These genes are similar in that they are all connected to the Jak-Stat …
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The roles of hepatocyte growth factor family members in androgen-regulation of human hair growth. A comparison of the expression of hepatocyte growth factor family members, HGF and MSP, and their receptors, c-Met and RON, in isolated hair follicles from normal and androgenetic alopecia (balding) scalp.
Androgens are the main regulators of human hair growth stimulating larger, terminal hair development e.g. beard and causing scalp balding, androgenetic alopecia. Hair disorders cause psychological distress but are poorly controlled. Androgens probably act by altering regulatory paracrine factors …
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The role of fibrolast-derived cytokines on melasma
… radiation, sex hormone, and genetic predisposing factors, however, the exact mechanism of pathogenesis is not clearly demonstrated. Previous studies have been bringing focus into the pigmentation formed by interaction between keratinocytes and melanocytes. Recently, it was reported that dermal …
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The role of PAK6 in HGF-induced prostate cancer cell migration
… single cells adopting a migratory morphology. Hepatocyte growth factor (HGF) signalling is known to induce cell-cell dissociation and is associated with prostate carcinoma progression. HGF-induced cell-cell dissociation and migration require the activity of the Rho family GTPases Rho A, Racl …
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Targeting c-Met for therapy
… which is activated by its only ligand, the hepatocyte growth factor (HGF). Activation of c-Met leads to a wide spectrum of biological activities such as motility, angiogenesis, morphogenesis, cell survival and cell regeneration. c-Met and HGF knock-out mice are embryonic lethal. During …
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Function and Regulation of the Cell Fate Determinant Numb in Polarized Epithelial Cells
… chelating agents. Loss of Numb potentiates hepatocyte growth factor (HGF)-induced lamellipodia formation and cell dispersal – early steps in epithelial-mesenchymal transition (EMT). In Numb-depleted cells, Rac1-GTP loading is enhanced, which corresponds with increased rate in loss of …
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hepatocyte growth factor inhibits glial scar formation and
Formation of glial scars physically impedes growth of regenerating axons following CNS injuries such as spinal cord trauma. Glial scars also produce various species of chondroitin sulfate proteoglycans (CSPGs) that act as a potent inhibitor of axon growth. Thus, inhibition of glial scar formation …
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The role of heparin and heparin-binding growth factors in pre-eclampsia
… hypothesis that expression of heparin-binding growth factors (HBGFs) in normal placental development was altered in a specific pregnancy disorder preeclampsia. HBGFs bind to heparin, a glycosaminoglycan (GAG) affecting activity. I investigated the role of heparin and HBGFs in pathophysiology of …
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Invadopodia Formation in Breast Cancer
… progression can be driven by signalling via growth factors such as hepatocyte growth factor (HGF) and by the surrounding microenvironment. During initial tumour expansion intratumoral hypoxia can develop due to inadequate vasculature supply. To resist the negative effect of hypoxia, cells …
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Activation of HGF/Met Signaling Induces Delayed STAT3 Phosphorylation
… responses following activation by its ligand, hepatocyte growth factor (HGF, also known as scatter factor). Activation of HGF-Met signaling is known to play potentially important roles in tumorigenesis. STATs mediate many of the cellular responses that occur following cytokine, growth factor, …
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Elucidating the role of the EGFR-family members in cell motility through the use of novel engineered bivalent ligands
… and metastases. MET and members of the epidermal growth factor receptor (EGFR)- family are cell-surface receptor tyrosine kinases (RTK) commonly upregulated in NSCLC cells, and their signaling crosstalk can confer therapy resistance. The four EGFR-family members are similar in structure; each …
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Regulation of satellite cells by extrinsic factors during recovery from exercise in horses
… to the nearby muscle after a damaging event. Hepatocyte growth factor (HGF) and insulin-like growth factor-1 (IGF-1) transcript abundance increased after an exhaustive bout of endurance exercise in concert with myogenic regulator factors and preceding increased SC abundance in a previous …
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Development of Delivery Strategy for Adipose-Derived Stem Cells in the Treatment of Myocardial Infarction
… injectable biomaterial combined with chemotactic growth factor delivery to enhance ASC retention within the gel. Working towards future in vivo analysis in a rat model, multilineage characterization studies confirmed that ASCs isolated from the epididymal fat pad of male Wistar rats could …
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Molecular Insights and Physiological Consequences of Aryl Hydrocarbon Receptor Regulated Plasminogen Activator Inhibitor-1 Expression
… receptor (AhR), a ligand-activated transcription factor, attenuates liver regeneration in vivo when activated by its prototypical agonist 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) following 70% partial hepatectomy (PH). One reported target of the AhR that may account for suppression of the …
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A mechanism of activation of c-MET receptor tyrosine kinase
… signaling molecules that are activated following hepatocyte-growth factor (HGF)-induced activation of c-MET had been established, little was known about the mechanism of activation of c-MET. From a therapeutic perspective, it is necessary to understand the detailed molecular mechanisms regulating …
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