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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 98 for “"Hepatocellular Carcinoma (HCC)"”.

  1. CHARACTERIZATION OF HEPATITIS B VIRUS (HBV) IN HEPATOCELLULAR CARCINOMA (HCC) PATIENTS

    TOH SOO TING2013

    … infection is epidemiologically associated with hepatocellular-carcinoma (HCC) but its role in HCC remains poorly understood due to technological limitations. Here, we systematically characterize HBV in HCC patients. HBV sequences were enriched from 48 HCC patients using an oligo-bead-based …

    nus Repository record

  2. The severity and activity of liver disease in chronic hepatitis C infection

    Haydon, Geoffrey HaroldThe University of Edinburgh1999

    … common complications are hepatic cirrhosis and hepatocellular carcinoma (HCC); presently it is unclear whether all infected patients will develop these complications.

    edinburgh Repository record

  3. Impairments in signaling cascades mediating the progression of liver disease from chronic hepatitis to hepatocellular carcinoma in animal and human models

    Setshedi, MashikoDepartment of Medicine2011

    … for chronic liver disease, cirrhosis, and hepatocellular carcinoma (HCC) include chronic alcohol abuse and infection with hepatitis B (HBV) or hepatitis C (HCV) virus. Growing evidence from human studies and experimental models suggests that pre-degenerative and premalignant abnormalities …

    cape-town Repository record

  4. RNA EDITING INDEPENDENT FUNCTIONS OF ADENOSINE DEAMINASES ACTING ON DOUBLE-STRANDED RNA IN HEPATOCELLULAR CARCINOMA

    QI LIHUA2015

    … EDITING HAS BEEN REPORTED TO CONTRIBUTE TO HEPATOCELLULAR CARCINOMA (HCC) DEVELOPMENT. HOWEVER A-TO-I EDITING IS MOSTLY ENRICHED IN 3? UNTRANSLATED REGIONS (3?UTRS) AND THE ASSOCIATED FUNCTIONS REMAIN LARGELY UNCLEAR. HERE, WE INVESTIGATED THE REGULATIONS OF ADARS ON TARGET GENES WITH …

    nus Repository record

  5. DESIGNING ANTI-PDL1 ANTIBODY CONJUGATED POLYMERIC COACERVATES AS A NOVEL “NANO-IMMUNOTHERAPY” AGAINST HEPATOCELLULAR CARCINOMA

    CHERYLETTE ANNE ALEXANDER2022

    Hepatocellular Carcinoma (HCC) accounts for a majority of primary liver cancer cases and is among the deadliest cancers in the world. With a shift in major risk factors from chronic viral hepatitis infections to that of metabolic diseases causing HCC, the number of HCC-related cases and deaths is …

    nus Repository record

  6. Analisi integrata dell'espressione di geni/microrna in un modello di epatocancerogenesi sperimentale

    MANCA, CLAUDIAUniversità degli Studi di Cagliari2013

    Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world, accounting for an estimated half million deaths annually, and represents one of the major health problems. Although much is known about the cellular changes that lead to HCC, the molecular pathogenesis of HCC is not yet …

    cagliari Repository record

  7. IDENTIFICATION OF Cav 3.2 T-TYPE VOLTAGE GATED CALCIUM CHANNELS AS KEY MEDIATORS OF TARGETED INHIBITION OF HEPATOCELLULAR CARCINOMA BY AMPLITUDE-MODULATED RADIOFREQUENCY ELECTROMAGNETIC FIELDS

    Jimenez, HugoWake Forest University2018

    … and metastatic tumors in patients with advanced hepatocellular carcinoma (HCC). The mechanism by which AM RF EMF have direct antiproliferative eff ect ca ncer cells is largely unknown. In order to deduce the unknown mechanism of action w e have a ssessed the Specific Absorption Rate (SAR) level …

    wfu Repository record

  8. Il-6/Jak1 Drives Pd-L1 Phosphorylation and Glycosylation to Promote Cancer Immune Evasion

    Chan, Li-Chuan, <p>https://orcid.org/0000-0002-2665-637X</p>2020

    … was observed in tumor samples from patients with hepatocellular carcinoma (HCC). Furthermore, IL-6 blockade led to downregulation of PD-L1 and increased sensitivity to anti-T-cell immunoglobulin mucin-3 (Tim-3) immune checkpoint therapies in animal models. These results identify a mechanism …

    uthsc Repository record

  9. Identification of novel transcripts in hepatocellular carcinoma using RNA-seq

    김, 윤희2016

    … transcripts which might play functional roles in hepatocellular carcinoma (HCC) using reference based assembly method, which revealed 20 novel candidate transcripts. With those candidate transcripts, I predicted whether they have functions involved in cancer progression. Firstly, I identified …

    ajou Repository record

  10. Detection of Novel Genomic Markers for Predicting Prognosis in Hepatocellular Carcinoma Patients by Integrative Analysis of Copy Number Aberrations and Gene Expression Profiles: Results from a Long-Term Follow-Up

    조, 효정2016

    … explore for novel genomic biomarker predicting hepatocellular carcinoma (HCC) prognosis by integrative analysis of DNA copy number aberrations (CNAs) and gene expression profiles. Array comparative genomic hybridization and expression array were performed on 45 and 31 HCC samples, respectively. …

    ajou Repository record

  11. The role of PLK1 in Hepatitis B Virus (HBV) infection of the liver

    Diab, Ahmed Mohamed Abdel-B

    … linked to increased risk for development of hepatocellular carcinoma (HCC). Current treatments to control chronic HBV infection remain ineffective. New and effective therapies that target the persisting viral molecules are needed in order to clear infection. My research aims to understand the …

    purdue-thes Repository record

  12. Transcriptional response and DNA adduct analysis of murine liver exposed to aflatoxin B₁ by Jeanette Louise Allen Fiala.

    Fiala, Jeanette Louise AllenMassachusetts Institute of Technology2009

    … exposure to aflatoxin B1 (AFB1) is linked to hepatocellular carcinoma (HCC), especially in areas where significant hepatitis B infection is concurrent. Susceptibility to this carcinogen varies among species. Neonatal mice, like rats and most other species, are highly sensitive to the …

    mit Repository record

  13. THE ROLE OF TETRASPANIN-8 IN ASTROCYTE ELEVATED GENE-1 MEDIATED PROGRESSION OF HEPATOCELLULAR CARCINOMA

    Akiel, Maaged2017

    Hepatocellular carcinoma (HCC) is a devastating form of liver cancer that accounts for 80% of liver cancers. HCC has a poor prognosis with five-year survival of less than 12% in the United States. We in previous studies have identified Astrocyte Elevated Gene-1 (AEG-1) as an aberrantly …

    vcu Repository record

  14. Alterations in Genomic 5-Hydroxymethylcytosine Level in Hepatocellular Cancer

    Mustafa, MufaddalThe Ohio State University2013

    Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death worldwide. There are a limited number of therapeutic options currently available to delay the advancement of HCC, and the chance of survival decreases as the disease progresses. DNA methylation of certain tumor …

    ohiolink Repository record

  15. Advances in estimation and inference around a biomarker’s true and false classification rates under trichotomous settings

    Shi, PengUniversity of Kansas2022

    … our approaches to a real data set that involves hepatocellular carcinoma (HCC)patients. HCC is the most common cancer of the liver and the ninth leading cause of cancerrelated death in the United States. Our approaches can provide deeper insights regarding the accuracy of the candidate biomarker, …

    ku Repository record

  16. Clinical and Pathologic Characteristics of Hepatocellular Carcinoma following Resection according to the Tumor Size

    조, 성연, 최, 진혁2011

    A tumor size of hepatocellular carcinoma (HCC) has been known to be an important prognostic factor after resection and it is considered to be closely correlated with vascular invasion of HCC. We aimed this study to elucidate the outcomes according to some previously studied size criteria and the …

    ajou Repository record

  17. NONCANONICAL PYROPTOSIS PROMOTES NONALCOHOLIC STEATOHEPATITIS VIA LIPID PEROXIDATION AND TRAINED IMMUNITY

    Drummer, CharlesTemple University. Libraries2022

    … to liver cirrhosis, end-stage liver disease and hepatocellular carcinoma (HCC). Additionally, recent data suggest that nonalcoholic steatohepatitis (NASH), the inflammatory phase of NAFLD, is linked to increased cardiovascular risk independent of the broad spectrum of risk factors of metabolic …

    temple Repository record

  18. Differences in miR-122 and miR-191 Expression in HBV- versus HCV-associated Hepatocellular Carcinoma

    Spaniel, CarolynThe University of Texas Medical Branch at Galveston2016

    … is decreased and increased, respectively, in hepatocellular carcinoma. However, other evidence suggests miR-122 may be preserved in HCV-associated hepatocellular carcinoma (HCC). The goal of this thesis is to assess miR-122 and miR-191 expression levels in HBV- and HCV-associated HCC, the …

    utmb Repository record

  19. Advancement of 31P Magnetic Resonance Spectroscopy Using GRAPPA Reconstruction on a 3D Volume

    Clevenger, Tony

    … assessment of tumor response in patients with Hepatocellular Carcinoma (HCC) treated with Stereotactic Body Radiation Therapy (SBRT) [3–5], as well as assessment of radiation toxicity, which can result in worsening liver dysfunction [6]. Pilot data from our lab has shown that 31P MRSI has the …

    purdue-thes Repository record

  20. The Role of FOXO3 in Mechanisms of Doxorubicin Resistance in Hepatocellular Carcinoma

    Cox, JosiahUniversity of Kansas2016

    … with doxorubicin is commonly used to treat hepatocellular carcinoma (HCC), but has limited efficacy due to a high level of resistance. The factors that determine the sensitivity to TACE-doxorubicin are unknown. FOXO3 is a multifunctional transcription factor that plays a role in determining …

    ku Repository record

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