Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Hepatoblastoma"”.
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Ribonucleotide Reductase Subunit Switching in Hepatoblastoma Drug Response and Relapse
<p>Hepatoblastoma is the most common primary liver cancer in infants and young children. Despite being a very rare cancer that accounts for only 0.5-2% if all childhood cancer cases, HB has the largest increase in incidence among childhood cancers in the United States and worldwide. The five-year …
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Analysis of NEIL3 expression : a possible resistance factor to cancer chemotherapy in paediatric cancer cells
… and steroid resistant cells), osteosarcoma, hepatoblastoma and medulloblastoma tumours. An initial assessment of whether the levels of NEIL3 expression are indicative of the response of paediatric tumours to sensitivity to DNA damaging agents was also carried out using the hepatoblastoma and …
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Assessing Parental Attitudes Towards Hepatoblatosma Screening
… FAP have up to a 2% risk for the development of hepatoblastoma (HB). Guidelines for HB screening are not well established, as screening for HB is controversial. The objectives of this study were to assess parental awareness of HB risk, as well as parental attitudes and beliefs regarding clinical …
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Hereditary and inborn etiology of pediatric cancer
… individual cancer types AML, renal tumors, and hepatoblastoma. The final study reviewed examines common genetic variation associated with pediatric osteosarcoma (OS). A small subset of individuals develop OS due to a hereditary predisposition syndrome such as Li Fraumeni, Retinoblastoma, or …
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Branching into RNAi: Synthesis, Characterization and Biology of Branch and Hyperbranch siRNAs
… their biological activity was assessed in HepG2 hepatoblastoma cells, which constitutes a morbid form of pediatric liver cancer and a valid tumor model for studying our GRP78-targeting strategy. The GRP78 silencing activity of the putative branch and hyperbranch siRNAs is discussed and related to …
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Poly(Arginine) Derived Cancer-Targeting Peptides for the Development of a Cancer-Targeted Gene Therapy Approach in HepG2 Liver Cancer Cells
… relationships were next assessed in HepG2 hepatoblastoma cells, in which the cancer-targeting peptides were found to bind to the GRP78 receptor and internalize within the HepG2 cells. This discovery has led to their applications in cancer-targeted gene therapy, from which a GRP78-silencing …
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Characterisation of a novel bioactive complex polysaccharide from a marine invertebrate with potent anticancer and antimalarial activities
… of protein HER2- SKBR3 cell line, the hepatoblastoma-derived cell line (Hep G2), chronic myelogenous leukaemia (K562), TNBC and mammosphere formation in breast cancer subtypes, and on malaria has been investigated in vitro using drug sustainable assays. Focusing on TNBC, the label-free …