Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 123 for “"Hepatitis C virus"”.
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Molecular Mechanisms of Hepatitis C Virus- Associated Steatosis
Hepatitis C virus (HCV) infects millions of people worldwide and is one of the leading causes of liver damage. Infection with HCV is strongly correlated with an increased risk of steatosis, or fatty liver disease, which is caused by a build-up of fat deposits in hepatocytes. All genotypes of HCV …
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The Multifunctional Capsid Gene of Hepatitis C Virus
<p>In populations worldwide, the Hepatitis C Virus displays great diversity. The capsid gene, however, is remarkably conserved and this has led to predictions of RNA secondary structure and an overlapping, alternative reading frame (ARF). We investigated a role of the ARF in HCV infection, by …
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T-lymphocyte senescence and hepatitis C virus infection
Hepatitis C virus (HCV) infection is a leading cause of cirrhosis and hepatocellular carcinoma. The degree of fibrosis progression and treatment-related outcomes are critically dependent on the age of the infected individual. Progressive ageing is associated with a decline in the efficacy of …
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The function of the hepatitis C virus p7 protein
The Hepatitis C Virus is the most common cause of chronic liver disease. Current therapy is only partially effective and fraught with side effects. A greater understanding of viral replication and new virus particle formation is thus important for developing new therapeutic targets. The HCV p7 …
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Interferon-gamma hemmt die Replikation des Hepatitis-C-Virus
Das Hepatitis C Virus (HCV) ist die Ursache für die chronische Hepatitis C, eine Erkrankung, die häufig zu den schweren Komplikationen Leberzirrhose und hepatozelluläres Karzinom führt. Die Behandlung erfolgt mit einer Kombination aus IFN- und Ribavirin. Mit dieser Therapie wird bei der akuten …
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Natural Killer Cell Responses in Chronic Hepatitis C Virus Infection
BACKGROUND: Hepatitis C virus (HCV) has infected 170 million people worldwide and is a leading cause of chronic viral hepatitis, liver cirrhosis, and hepatocellular carcinoma. Liver injury and disease progression in hepatitis C virus infection is driven by the host immune response. Previous …
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Identification of Host Factors Required for Hepatitis C Virus Infection
Hepatitis C virus (HCV), a positive-strand RNA virus, infects more than 170 million people and is the leading cause of liver failure worldwide. A protective vaccine is not yet available. Current interferon-based therapies are only effective in a fraction of patients. Thus, there is an urgent need …
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Resistance to hepatitis C virus : potential genetic and immunological determinants
… Population studies of those at high risk for hepatitis C virus (HCV) infection suggest that a HESN phenotype exists. There is a growing body of evidence for protective immunity, which allows clearance of HCV without seroconversion, and proof-of-principle evidence from in vitro studies that …
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A Genomic Portrait of Hepatitis C Virus and MicroRNA-122
<p>Hepatitis C virus (HCV) uniquely requires the liver specific microRNA-122 (miR-122) for replication, yet global effects on endogenous microRNA (miRNA) targets during infection are unexplored. In this body of work, we employed highthroughput sequencing and crosslinking immunoprecipitation …
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Characterization of Hepatitis C Virus Infection of Hepatocytes and Astrocytes
… the world population is currently infected with hepatitis C virus (HCV). Neutralizing antibodies (nAbs) are often generated in chronic hepatitis C patients yet fail to control the infection. In the first two chapters of this study, we focused on two alternative routes of HCV transmission, which …
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The interaction of hepatitis C virus and intracellular lipid metabolism
Chronic hepatitis C virus (HCV) infection causes inflammation of the liver, which can lead to fibrosis and cirrhosis over time. Whether liver damage is a consequence of viral infection or is due to an immune mediated response is not clear. Steatosis is a histopathological feature often found in HCV …
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Defining the mechanism(s) of Hepatitis C virus (HCV) entry
Hepatitis C virus (HCV) is a major human pathogen and the leading cause of cirrhosis and liver cancer worldwide. HCV entry is clathrin- and pH-dependent, and requires CD81, Scavenger receptor BI (SR-BI), and the tight junction (TJ) proteins Claudin-1 and Occludin. Primary HCV strains cannot be …
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Platforms for exploring host-pathogen interactions in hepatitis C virus infection
Afflicting almost 200 million worldwide, hepatitis C virus (HCV) mounts a chronic infection of liver hepatocytes that causes substantial morbidity and mortality. An understanding of host-virus interactions will drive the development of therapeutics, but research is restrained by available …
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Induction and Regulation of CXCL10 in Hepatocytes During Hepatitis C Virus Infection
Chronic Hepatitis C affects an estimated 170 million people worldwide and 4 million in the United States. The pro-inflammatory chemokine CXCL10 is induced by hepatitis C virus (HCV) infection <italic>in vitro</italic> and <italic>in vivo</italic>, and is associated with the outcome of interferon …
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MIR-122 and DDX6 facilitate hepatitis C virus replication via independent mechanisms
Globally 130 million people are infected with hepatitis C virus (HCV) that leads to chronic hepatitis. Current therapy is limited in its efficacy; hence better interventions are required. A detailed understanding of the host factors involved in HCV replication such as miR-122 and DEAD-box RNA …
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Modelling the spread of hepatitis C virus amongst people who inject drugs
… world. One of the most crucially overlooked is hepatitis C virus (HCV) which directly affects 3% of the global population (Akhtar et al. (2022)) and countless more indirectly. In a span of two decades after discovery, HCV has evolved to become the number one cause of liver disease globally …
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Hepatitis C virus infection in patients receiving opiate substitution therapy in Sweden.
The hepatitis C virus (HCV) is a blood borne virus effectively spread through injection practices. Consequently, people who inject drugs (PWID) are at the center of the current HCV epidemic in industrialized countries, with regards both to prevalence and incidence. Through progressive liver …
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Molecular Analysis of Hepatitis C Virus Envelope Glycoprotein E2 Binding and Entry
The envelope of the hepatitis C virus (HCV) mediates entry into cells by binding directly to the cluster of differentiation 81 receptor (CD81) and to the scavenger receptor class B type 1 (SR-B1). The critical incorporation of claudin-1 receptor (CLDN-1) and occludin receptor (OCLN) (indirect …
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Hepatitis C Virus-Induced Hepatocellular Carcinoma: Cancer Stem Cell and Gene Therapy
<p>Hepatitis C virus (HCV) is an important human pathogen that causes chronic hepatitis cirrhosis, steatosis and hepatocellular carcinoma (HCC) worldwide. Although current FDA-approved drugs are partially effective in the treatment of HCV, methods for cure and vaccine against the virus are still …
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BIO-MATHEMATICS: INTRODUCTION TO THE MATHEMATICAL MODEL OF THE HEPATITIS C VIRUS
… element. The biological element of study is the Hepatitis C virus. The idea in creating a mathematical model is to approach the biological element in small steps. We will first introduce a block (schematic) diagram of the element, create differential equations that define the diagram, convert the …
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