Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Hepatitis C, Chronic"”.
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Avaliação do desempenho do índice APRI no diagnóstico de fibrose hepática em pacientes com Hepatite C crônica: uma revisão sistemática
… com “liver fibrosis” ou “liver fibroses” com “chronic hepatitis C” ou “hepatitis C, chronic”. Foram utilizados os filtros “Clinical Trial” e “Human”, e foram selecionados artigos em português, inglês ou espanhol. Resultados: Foram identificadas 292 publicações inicialmente, além de mais 8 …
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Characterizing B Cell Phenotype During Chronic HCV Infection
Chronic hepatitis C virus (HCV) infection is characterized by an attenuation of virus-specific T cell responses. The mechanisms leading to T cell attenuation are still not well understood, and likely involve several integrating correlates. We hypothesized that dysfunctions of antigen presenting …
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Hepatitis C Virus NS3/4A Protease and the Intracellular Antiviral Response: Mapping Complex Virus-Host Interactions
… response is critical for immunity to infection. Hepatitis C virus (HCV) is a serious global health problem with 170 million people chronically infected. HCV persistence is linked to viral regulation of innate host defenses by the nonstructural 3/4A protein complex (NS3/4A) cleavage of IPS-1. NS3 …
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Peripheral Generation of Regulatory T Cells in Health and Disease
… Tregs are increased in the peripheral blood of chronic hepatitis C virus-infected patients and their depletion in-vitro increases anti HCV responses when measured by a sensitive CFSE-based flow cytometric proliferation assay. The CFSE-based assay, developed and validated by my laboratory, has a …
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Natural Killer Cell Responses in Chronic Hepatitis C Virus Infection
BACKGROUND: Hepatitis C virus (HCV) has infected 170 million people worldwide and is a leading cause of chronic viral hepatitis, liver cirrhosis, and hepatocellular carcinoma. Liver injury and disease progression in hepatitis C virus infection is driven by the host immune response. Previous …
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Role of Macrophage Subsets in CD8+ T Cell Dysfunction in Chronic HCV Infection
Chronic HCV infection causes generalized CD8+T cell impairment, not limited to HCV-specific CD8+ T cells. Infiltrating monocyte-derived macrophages contribute to a micro- environment that could impact CD8+T cells trafficking through the liver. Macrophages can differentiate into pro-inflammatory …