Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 217 for “"Hepatitis C"”.
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Einfluss von Immunsuppression auf Hepatitis C-assoziierte Immunphänomene und Hepatitis C-Quasispezies
Eine chronische Hepatitis C Infektion geht mit vielfältigen Autoimmunphänomenen einher. Deren klinische Bedeutung, sowie die Auswirkungen der HCV-assoziierten Kryoglobulinämie und der Komplementaktivierung auf die Transplantatfunktion bei nierentransplantierten Patienten wurden in dieser Arbeit …
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"Constructing" Hepatitis C in Philadelphia
This research explores how the CDC Hepatitis Epidemiology Investigation Team at the Philadelphia Department of Public Health (PDPH) constructs Hepatitis C (HCV) in the public and medical discourse through their monitoring and education activities. Data in the form of field notes and ethnographic …
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Experiences of injecting drugs, alcohol use and hepatitis C in Merseyside: Barriers to hepatitis C support
Hepatitis C is a blood borne virus affecting the liver. In the UK, approximately 214,000 people are infected with the hepatitis C virus. Hepatitis C disproportionally affects marginalised populations and in the UK sharing equipment used to inject drugs is the main risk factor for hepatitis C …
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The Multifunctional Capsid Gene of Hepatitis C Virus
<p>In populations worldwide, the Hepatitis C Virus displays great diversity. The capsid gene, however, is remarkably conserved and this has led to predictions of RNA secondary structure and an overlapping, alternative reading frame (ARF). We investigated a role of the ARF in HCV infection, by …
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Health Utilities in People with Chronic Hepatitis C
Background: Hepatitis C virus infection is associated with reduced quality of life. One way to measure the quality of life of hepatitis C patients is using health utilities. Health utilities provide insight into not only the state of a patient’s health but also the strength of preference for that …
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Patterns of Selection In Hepatitis C and Hiv
<p>Viruses, such as Hepatitis and HIV, are able to evade the host immune responses they provoke and often lead to chronic infections and even death. Global estimates reveal that 130 million people are infected with Hepatitis C, while the number of people living with HIV/AIDS is 33.4 million. The …
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Molecular Mechanisms of Hepatitis C Virus- Associated Steatosis
Hepatitis C virus (HCV) infects millions of people worldwide and is one of the leading causes of liver damage. Infection with HCV is strongly correlated with an increased risk of steatosis, or fatty liver disease, which is caused by a build-up of fat deposits in hepatocytes. All genotypes of HCV …
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Molecular Mechanisms of Protection from Hepatitis C Infection
Hepatitis C virus (HCV) infection is a major global health burden affecting 1-2% of the world’s population. The majority of infected individuals will develop chronic infection and are at risk of cirrhosis and hepatocellular carcinoma. There is currently no preventative vaccine available for HCV. In …
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T-lymphocyte senescence and hepatitis C virus infection
Hepatitis C virus (HCV) infection is a leading cause of cirrhosis and hepatocellular carcinoma. The degree of fibrosis progression and treatment-related outcomes are critically dependent on the age of the infected individual. Progressive ageing is associated with a decline in the efficacy of …
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Integrating Health Psychology into Hepatitis C treatment: a self-efficAcy intervention to reDuce injecting risk behAviour and hePatitis c reinfecTion rates (ADAPT)
… drugs (PWID) is a significant risk factor for hepatitis C virus (HCV) infection. Self-efficacy has been shown to be associated with injecting risk behaviour. The risk of HCV re-infection in people who inject drugs (PWID) treated for HCV remains high when sharing of injecting equipment continues …
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Fatigue und Lebensqualität bei Patienten mit chronischer Hepatitis C
… cognitive abilities with patients with chronic hepatitis C. In the present study 46 patients with chronic hepatitis C, 13 patients with chronic hepatitis B, 22 patients with not virale hepatitis were enclosed and compared to control group with a chronically not hepatic illness 32 patients with a …
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The function of the hepatitis C virus p7 protein
The Hepatitis C Virus is the most common cause of chronic liver disease. Current therapy is only partially effective and fraught with side effects. A greater understanding of viral replication and new virus particle formation is thus important for developing new therapeutic targets. The HCV p7 …
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Hepatitis C: A Perspective Through the Social Ecological Model
<p>Hepatitis C virus (HCV) is a major global public health problem. The Center for Disease Control and Prevention (CDC) estimates that the Hepatitis C virus (HCV) affects 3.2 million Americans and 500 million people from a global standpoint (CDC, 2012). HCV contributes to significant morbidity and …
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Interferon-gamma hemmt die Replikation des Hepatitis-C-Virus
Das Hepatitis C Virus (HCV) ist die Ursache für die chronische Hepatitis C, eine Erkrankung, die häufig zu den schweren Komplikationen Leberzirrhose und hepatozelluläres Karzinom führt. Die Behandlung erfolgt mit einer Kombination aus IFN- und Ribavirin. Mit dieser Therapie wird bei der akuten …
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Identification of Host Factors Required for Hepatitis C Virus Infection
Hepatitis C virus (HCV), a positive-strand RNA virus, infects more than 170 million people and is the leading cause of liver failure worldwide. A protective vaccine is not yet available. Current interferon-based therapies are only effective in a fraction of patients. Thus, there is an urgent need …
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The interaction of hepatitis C virus and intracellular lipid metabolism
Chronic hepatitis C virus (HCV) infection causes inflammation of the liver, which can lead to fibrosis and cirrhosis over time. Whether liver damage is a consequence of viral infection or is due to an immune mediated response is not clear. Steatosis is a histopathological feature often found in HCV …
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Thrombozytenantikörper bei Hepatitis-C-Infektion für die Diagnose einer Autoimmunthrombozytopenie
… if thrombocytopenia in patients with a chronic hepatitis C virus infection is caused through specific platelet autoantibodies. Which influence has the therapy with alpha-interferon on the development of platelet antibodies? Does the viral load, the HCV-genotype and the state of fibrosis …
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Heterozygote Hämochromatose-Genmutationen als genetische Progressionsfaktoren bei chronischer Hepatitis C
Background: Chronic hepatitis C is frequently associated with increased hepatic iron stores. It remains controversial whether heterozygous mutations of hemochromatosis genes affect fibrosis progression. Therefore our aim was to assess associations between HFE mutations and hepatic inflammation and …
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Natural Killer Cell Responses in Chronic Hepatitis C Virus Infection
BACKGROUND: Hepatitis C virus (HCV) has infected 170 million people worldwide and is a leading cause of chronic viral hepatitis, liver cirrhosis, and hepatocellular carcinoma. Liver injury and disease progression in hepatitis C virus infection is driven by the host immune response. Previous …
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