Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 55 for “"Hepatitis B virus (HBV)"”.
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CHARACTERIZATION OF HEPATITIS B VIRUS (HBV) IN HEPATOCELLULAR CARCINOMA (HCC) PATIENTS
Chronic Hepatitis B Virus (HBV) infection is epidemiologically associated with hepatocellular-carcinoma (HCC) but its role in HCC remains poorly understood due to technological limitations. Here, we systematically characterize HBV in HCC patients. HBV sequences were enriched from 48 HCC patients …
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The role of PLK1 in Hepatitis B Virus (HBV) infection of the liver
… million reported chronic infections globally, Hepatitis B Virus (HBV) is a major human health issue, linked to increased risk for development of hepatocellular carcinoma (HCC). Current treatments to control chronic HBV infection remain ineffective. New and effective therapies that target the …
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Compartmental Hepatitis B Virus (HBV) Evolution, Replication and Infectivity in vivo and ex vivo
Hepatitis B Virus (HBV) is classically considered a hepatotropic virus, however, the presence of different HBV genomic molecules in lymphoid cells and tissues support its lymphotropic nature. Our previous studies showed that HBV evolved in a compartment- and disease phase-specific fashion. However, …
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Emergence of Adefovir-resistant Mutants after Reversion to YMDD Wild-type in Lamivudine-resistant Patients
The levels of hepatitis B virus (HBV) DNA have been reported to be a predominant viral risk factor associated with increased rates of cirrhosis and hepatocellular carcinoma. Lamivudine (LAM) is the first nucleoside analogue approved for the treatment of Chronic hepatitis B (CHB) with good potency, …
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Functional Role of Hepatitis B Virus Core Protein in Viral Replication
… carboxyl-terminal nucleic acid binding domain of HBV core protein for hepatitis B virus (HBV) replication, chimeric HBV core proteins were generated by substituting varying lengths of the carboxyl-terminus of duck hepatitis B virus (DHBV) core protein for the corresponding regions of HBV core …
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C-terminus of Hepatitis B virus RNase H Domain is Important for HBV replication
Hepatitis B Virus (HBV) DNA polymerase (P) protein consisting of terminal protein (TP), spacer, reverse transcriptase (RT), and RNase H, plays critical roles in viral assembly and replication. RNase H domain is required for HBV DNA replication, however critical motif or amino acid residues in the …
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MOLECULAR BIOLOGY OF HEPATITIS B VIRUS DNA-CELL INTERACTION
Liver-specificity of hepatitis B virus (HBV) replication has been attributed to the action of its second enhancer (EII). This thesis reports the characterization of EII and the subsequent isolation of a novel liver-specific DNA-binding protein which binds to, and activates EII. The cDNA clone of …
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Development of Universal Biosensing Platforms Based on CRISPR/Cas12a systems
… through the nucleic acid detection of hepatitis B virus (HBV) and Grapevine Red-Blotch Virus (GRBV). The second developed method is a universal proximity CRISPR Cas12a assay for ultrasensitive detection of nucleic acids and proteins. The target recognition is achieved through proximity …
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Development and characterization of an in vitro culture system as a physiological model for chronic Hepatitis B infection
Human Hepatitis B virus (HBV) is the prototype member of the family Hepadnaviridae that consists of enveloped, partially double stranded DNA viruses that specifically target hepatocytes for viral replication. Although a vaccine has been available for more than 20 years chronic HBV infection …
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Virus-like particles as a vaccine against porcine reproductive and respiratory syndrome virus
… of new generation PRRS universal vaccines. Virus like particles (VLPs) based vaccines are gaining increasing acceptance compared to subunit vaccines, as they present the antigens in more veritable conformation and are even readily recognized by the immune system. Hepatitis B virus (HBV) core …
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Analysis of Treatment Effect of Lamivudine, Adefovir Add-on Therapy in Patients with Lamivudine Resistant Chronic B-viral Hepatitis
… for treatment of LAM resistance with chronic hepatitis B. We assessed the long?term efficacy (median follow-up of 20.18 months) of ADV add-on LAM therapy in 89 LAM-resistant patients. Methods: 89 patients (29.2% cirrhotics, 76.4% hepatitis B e antigen positive) with LAM resistant patients who …
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The Effect of Primary Hepatocyte Expressing HBx on the Activation and Apoptosis of Antigen-specific CD8+ T Cell
CD8^(+) T cells contribute to the control of Hepatitis B virus (HBV) infection by killing of infected cells or inhibiting viral replication inside cells. HBx, antigen of hepatitis B virus, plays an important role in the immunopathogenesis of HBV infection. Since HBx is able to upregulate cellular …
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Inter-alpha-trypsin inhibitor heavy chain H4 as a diagnostic and prognostic indicator in patients with hepatitis B virus-associated hepatocellular carcinoma
… in healthy controls and patients with chronic hepatitis B (CHB), hepatitis B virus (HBV)-related liver cirrhosis, and HBV-related hepatocellular carcinoma (HCC). DESIGN AND METHODS: The study enrolled 300 individuals (50 healthy controls, 50 with CHB, 100 with HBV-associated cirrhosis, and 100 …
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Multidrug-Resistant Hepatitis B Virus Resulting From Sequential Monotherapy With Lamivudine, Adefovir, and Entecavir: Clonal Evolution During Lamivudine Plus Adefovir Therapy
… & AIMS: Whether multidrug-resistant (MDR) hepatitis B virus (HBV) harbors mutations co-located in the same HBV clones that confer reduced sensitivity to antiviral therapy remains uncertain. This study investigated the evolution of MDR HBV strains developed from sequential monotherapy with …
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Association of Apolipoprotein E Genotypes with Disease Progression in Hepatitis B Virus Infected Patients
… ApoE genotype determine disease outcome in hepatitis B virus (HBV) infected individuals, and to verify the association with the occurrence of hepatocellular carcinoma (HCC) in patients with chronic liver diseases of various etiologies. Methods: This hospital based case-control study enrolled …
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The Intracellular Changes and the Localization of Core particles by Hepatitis B Virus P Protein-Deficient Mutant
PURPOSE: Hepatitis B virus (HBV) core particles move to ER or recycle back to the nucleus. This moving mechanism is thought to be important in HBV replication and HBV life cycles. P protein-deficient mutant can form core particles in the absence of P protein and pregenomic RNA (pgRNA). In this …
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Association between Chronic Hepatitis B Virus Infection and Interleukin-10, Tumor Necrosis Factor-α Gene Promoter Polymorphisms
The reasons for the viral persistence of hepatitis B virus (HBV) infection are unknown, but are probably related to host immune factors. Cytokines play significant roles in inflammatory and immune defense. This study was undertaken to investigate the association between HBV infection and …
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IDENTIFYING EARLY STEPS IN THE DEVELOPMENT OF HBV ASSOCIATED HCC
The hepatitis B virus (HBV), chronically infecting ~360 million people worldwide, accounts for over half of the cases of hepatocellular carcinoma (HCC) and contributes to over 650,000 deaths per year making HCC is the fifth most common and second most deadly form of cancer.1-3 Many genes …
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Examining the risk factors for hepatitis B infection among pregnant women attending antenatal care in Kunene region, a case control study
The Hepatitis B is a viral infection caused by Hepatitis B virus (HBV) which is a double stranded DNA virus, a member of the Hepadnavidae family of viruses. World Health Organization estimates that about 257 million people are living with Hepatitis B virus infection. Namibia has a high prevalence …
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An Assessment of Quality of Life among Hepatitis B Virus Carriers in China
Hepatitis B virus (HBV) is a serious public health problem in China. The quality of life (QOL) of the HBV carriers could be affected not only by the ailment and treatment, but also by social discrimination. The purpose of the this study was to assess the QOL of HBV carriers and to investigate the …
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