Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Hepatitis B Virus Infection"”.
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Genomic profiling and perturbation of Hepatitis B virus infection
The Hepatitis B virus (HBV) has, at one time or another, infected one third of the world's population, and over 300 million people worldwide are chronically infected, leading often to progressive liver damage, cirrhosis, and the development of hepatocellular carcinoma over decades. While an …
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Immune Control of Hepatitis B Virus infection by innate lymphocytes
Hepatitis B virus (HBV) infects over 300 million people worldwide and despite the availability of a vaccine, it remains the second biggest carcinogen in the world and a serious global health problem. The majority of adult infections are resolved while 90% of neonates fail to clear infection. …
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Clonal proliferation of hepatocytes during chronic hepatitis B virus infection.
Chronic hepatitis B virus (HBV) infection causes liver disease that can progress to cirrhosis and hepatocellular carcinoma (HCC). Changes in the hepatocyte population that occur from the early immune-tolerant stage of infection to late-stage disease outcomes remain unclear. We hypothesised that …
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Cytokine gene transfer by adenoviral vectors as a novel therapeutic option for hepatitis B virus infection
Hepatitis B virus (HBV) is a hepatotropic, non-cytopathic DNA virus that causes acute and chronic necroinflammatory liver disease and hepatocellular carcinoma. It has been shown that HBV DNA replication is suppressed by interferon (IFN) a/b, IFNg and other cytokines. The aim of my thesis was to …
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Association between Chronic Hepatitis B Virus Infection and Interleukin-10, Tumor Necrosis Factor-α Gene Promoter Polymorphisms
The reasons for the viral persistence of hepatitis B virus (HBV) infection are unknown, but are probably related to host immune factors. Cytokines play significant roles in inflammatory and immune defense. This study was undertaken to investigate the association between HBV infection and …
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Caspase-cleaved fragments of cytokeratin-18 as a marker of inflammatory activity in chronic hepatitis B virus infection
… diagnosis between inactive carrier and active hepatitis is important in patients with chronic hepatitis B (CHB) virus infection. Serum cytokeratin (CK)-18 fragments (M30 antigen) are proposed as biomarkers of apoptosis. We investigated whether serum M30 levels might help to characterize the …
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An investigation of genome-wide promoter region cytosine-phosphate-guanine (CpG) Island methylation profiles in patients with chronic hepatitis B virus infection
Hepatitis B virus (HBV) is oncogenic and a major cause of hepatocellular carcinoma (HCC) in the developing world. It integrates parts of its genome such as the HBx gene, core and surface antigens into the human genome. The integrated viral DNA disrupts gene function resulting in physiological …
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Association of the Interleukin-1 beta and Interleukin-1 Receptor Accessory Protein Gene Polymorphisms with Persistent Hepatitis B Virus Infection and Hepatocellular Carcinoma
"Background & Aims: The reasons for persistent hepatitis B virus infection (HBV) are unknown, but they are probably related to host immune factors. Interleukin-1β (IL-1β) plays significant roles in inflammation and immune defense via IL-1 receptor accessory protein (IL-1RAcP). We investigated …
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The Role of e-Antigen in Hepatitis B Infection
… years. In virology, particularly in the study of hepatitis B virus, mathematical models were used to explain interactions between hepatitis B virus and the human host in the absence and presence of interventions such as drug therapy and vaccines. This thesis seeks to explain the role of e-Antigen, …
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Chronic hepatitis at Groote Schuur Hospital: 1978-1996 : a literature review of the syndrome, its clinical spectrum and management at Groote Schuur Hospital
Chronic hepatitis has multiple aetiologies which include viral hepatitis (hepatitis B, B+D and C), autoimmune hepatitis and drugs. In sub-Saharan Africa the major aetiological factor is chronic hepatitis B virus infection. In this region 10-15% of the population is chronically infected with the …
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Examining the risk factors for hepatitis B infection among pregnant women attending antenatal care in Kunene region, a case control study
The Hepatitis B is a viral infection caused by Hepatitis B virus (HBV) which is a double stranded DNA virus, a member of the Hepadnavidae family of viruses. World Health Organization estimates that about 257 million people are living with Hepatitis B virus infection. Namibia has a high prevalence …
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Constraints on the CD8 T cell response in chronic HBV infection
The inflamed liver in chronic hepatitis B virus infection (CHB) is characterised by a large influx of non-virus specific CD8 T cells, which we hypothesize could provide insights into mechanisms of failure of viral control and liver damage in this setting. We compared the effector function of total …
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Mathematical and Numerical Investigation of Immune System Development and Function
… memory leading to fast responses to subsequent infections. While there is some agreement about the underlying mechanisms of adaptive immune memory, innate immune memory is poorly understood. Stimulation with lipopolysaccharide induces differential phenotypes in innate immune cells depending on …