Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 100 for “"Hepatitis B Virus"”.
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Initial Stages of Hepatitis B Virus Replication
… in Various Stage of DNA Replication Inside of hepatitis B virus (HBV) core particle, pgRNA is reverse transcribed by HBV DNA polymerase into minus-strand DNA and pregenomic RNA (pgRNA) is degraded concomitantly by RNase H activity of DNA polymerase. Then, plus-strand DNA is synthesized to …
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MOLECULAR BIOLOGY OF HEPATITIS B VIRUS DNA-CELL INTERACTION
Liver-specificity of hepatitis B virus (HBV) replication has been attributed to the action of its second enhancer (EII). This thesis reports the characterization of EII and the subsequent isolation of a novel liver-specific DNA-binding protein which binds to, and activates EII. The cDNA clone of …
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Charakterisierung von funktionellen Oberflächenstrukturen des Hepatitis-B-Virus Nukleokapsids
Während der Morphogenese des Hepatitis-B-Virus (HBV) geht das transmembrane große Hüllprotein (L-Protein) wahrscheinlich eine direkte Interaktion mit reifen zytosolischen Nukleokapsiden ein, deren Schale aus dem Coreprotein aufgebaut ist. Um die Beteiligung einzelner Aminosäuren (AS) des …
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Roles of Interferon Lambda on Hepatitis B Virus Replication
"Background/Aims: Chronic hepatitis B virus (HBV) infection is a major cause of liver disease. Only interferon-α (IFN-α) and the nucleosidic inhibitors of the viral polymerase, lamivudine and adefovir, are approved for therapy. However, these therapies are limited by the side effects of interferon …
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Genomic profiling and perturbation of Hepatitis B virus infection
The Hepatitis B virus (HBV) has, at one time or another, infected one third of the world's population, and over 300 million people worldwide are chronically infected, leading often to progressive liver damage, cirrhosis, and the development of hepatocellular carcinoma over decades. While an …
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Immune Control of Hepatitis B Virus infection by innate lymphocytes
Hepatitis B virus (HBV) infects over 300 million people worldwide and despite the availability of a vaccine, it remains the second biggest carcinogen in the world and a serious global health problem. The majority of adult infections are resolved while 90% of neonates fail to clear infection. …
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Kartierung von umhüllungsrelevanten Aminosäureresten auf dem Hepatitis B Virus Kapsid
Während der Morphogenese des Hepatitits-B-Virus (HBV) wird das cytosolisch gebildete Nukleokapsid, welches u.a. das virale Genom enthält, durch Interaktion mit den transmembran lokalisierten viralen Hüllproteinen an zellulären Membranen umhüllt und erscheint anschließend als Virion im ER-Lumen, von …
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Relationship between Hepatitis B Virus Core Particles and Intracellular Motility
PURPOSE: Hepatitis B virus (HBV) core particles recycle back to the nucleus. This recycling mechanism is thought to be important in maintaining covalently closed circular (cccDNA) pool in the nucleus. Transport of HBV core particles in host cytoplasm is important for HBV life cycle but the …
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Expression and Functional Analysis of Hepatitis B Virus DNA Polymerase
… of chimeric DNA polymerase of human and duck hepatitis B virus Hepatitis B Virus (HBV) DNA polymerase is a multifunctional protein with four domains, terminal protein (TP), spacer, reverse transcriptase (RT), and RNaseH. Since HBV DNA polymerase is very unstable and rapidly degradable, it has …
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Clonal proliferation of hepatocytes during chronic hepatitis B virus infection.
Chronic hepatitis B virus (HBV) infection causes liver disease that can progress to cirrhosis and hepatocellular carcinoma (HCC). Changes in the hepatocyte population that occur from the early immune-tolerant stage of infection to late-stage disease outcomes remain unclear. We hypothesised that …
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Mathematical Models of Hepatitis B Virus Dynamics during Antiviral Therapy
Antiviral therapy for patients infected with hepatitis B virus is only partially efficient. The field is in high demand for understanding the connections between the virus, immune responses, short-term and long-term drug efficacy and the overall health of the liver. A mathematical model was …
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Strategies for the induction of mucosal immunity against hepatitis B virus.
… of administration of plasmid DNA encoding the hepatitis B surface antigen (HBsAg) influences the strength and nature of immune responses in mice and non-human primates. Mucosal immunization using plasmid DNA in saline results in no or weak immune responses. Formulation of DNA with lipid …
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CHARACTERIZATION OF HEPATITIS B VIRUS (HBV) IN HEPATOCELLULAR CARCINOMA (HCC) PATIENTS
Chronic Hepatitis B Virus (HBV) infection is epidemiologically associated with hepatocellular-carcinoma (HCC) but its role in HCC remains poorly understood due to technological limitations. Here, we systematically characterize HBV in HCC patients. HBV sequences were enriched from 48 HCC patients …
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Functional Role of Hepatitis B Virus Core Protein in Viral Replication
… acid binding domain of HBV core protein for hepatitis B virus (HBV) replication, chimeric HBV core proteins were generated by substituting varying lengths of the carboxyl-terminus of duck hepatitis B virus (DHBV) core protein for the corresponding regions of HBV core protein. All chimeric …
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Entecavir Therapy for Patients with Hepatitis B Virus-Related Decompensated Cirrhosis
목적: 엔테카비어는 HBV에 강력한 항바이러스 효과가 있으며 내성이 드물게 발생한다. 비대상성 간경변증 환자에서 엔테카비어의 장기 치료 효과에 대한 연구 결과는 많지 않다. 이에 저자들은 B형 간염 바이러스에 의한 비대상성 간경변환자를 대상으로 엔테카비어 치료 효과와 엔테카비어 효과를 예측할 수 있는 인자를 알아보고자 하였다. 대상 및 방법: 2006년 11월부터 2011년 1월까지 아주대학교 병원에 내원한 만성 B형 간염으로 인한 비대상성 간경변 환자 중 6개월이상 엔테카비어 치료를 받은 45명을 후향적으로 조사하였다. 대상 …
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AMP-activated protein kinase-mTOR signaling pathway and hepatitis B virus replication
B형간염 바이러스(hepatitis B virus, HBV)는 Hepadnaviridae family에 속하며, genome 크기가 약 3.2kb의 작은 DNA 바이러스이다. 전 세계적으로 약 3억 5천만 명 이상이 만성으로 HBV에 감염되어 있다. HBV는 급성과 만성 B형 간염을 일으키며 만성 B형 간염 환자는 간경변이나 간암으로 발전할 가능성이 높다. AMP-activated protein kinase(AMPK)는 ATP 소비와 생성의 균형을 위해서 필요한 에너지 센서 단백질이다. Hepatitis C virus(HCV)의 …
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Studies of the interaction of hepatitis B virus with human haemopoietic cells.
This thesis studied aspects of the interaction of hepatitis B virus (HBV) with haemopoietic cells and cell lines, to address the reported tropism of HBV for haemopoietic tissues. Emphasis was directed at demonstrating specific attachment of HBV to defined subpopulations of peripheral blood …
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The role of PLK1 in Hepatitis B Virus (HBV) infection of the liver
… million reported chronic infections globally, Hepatitis B Virus (HBV) is a major human health issue, linked to increased risk for development of hepatocellular carcinoma (HCC). Current treatments to control chronic HBV infection remain ineffective. New and effective therapies that target the …
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