Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 176 for “"Hepatitis B"”.
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Characterising the immunopeptidome in hepatitis B
Characterising the immunopeptidome in hepatitis B Hepatitis B (HBV) is the leading cause of hepatocellular carcinoma (HCC) worldwide. There is presently no cure for HBV, and treatment options aim to reduce the risk of liver related complications and HCC. Immunotherapies have not been successful in …
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Initial Stages of Hepatitis B Virus Replication
… in Various Stage of DNA Replication Inside of hepatitis B virus (HBV) core particle, pgRNA is reverse transcribed by HBV DNA polymerase into minus-strand DNA and pregenomic RNA (pgRNA) is degraded concomitantly by RNase H activity of DNA polymerase. Then, plus-strand DNA is synthesized to …
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Biological Functions of Intracellular Hepatitis B e Antigen
The function(s) of the intracellular form of HBeAg, previously reported as the preCore protein intermediate (p22) without the N-terminal signal peptide, remains elusive. Here, we propose to elucidate the translocation of p22 during its formation from endoplasmic reticulum (ER) to cytosol, how it …
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MOLECULAR BIOLOGY OF HEPATITIS B VIRUS DNA-CELL INTERACTION
Liver-specificity of hepatitis B virus (HBV) replication has been attributed to the action of its second enhancer (EII). This thesis reports the characterization of EII and the subsequent isolation of a novel liver-specific DNA-binding protein which binds to, and activates EII. The cDNA clone of …
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Charakterisierung von funktionellen Oberflächenstrukturen des Hepatitis-B-Virus Nukleokapsids
Während der Morphogenese des Hepatitis-B-Virus (HBV) geht das transmembrane große Hüllprotein (L-Protein) wahrscheinlich eine direkte Interaktion mit reifen zytosolischen Nukleokapsiden ein, deren Schale aus dem Coreprotein aufgebaut ist. Um die Beteiligung einzelner Aminosäuren (AS) des …
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Structural and antigenic components of Hepatitis B surface antigen
Although the spread of hepatitis B infection has largely been controlled through the use of sophisticated serological tests for the detection of hepatitis B surface antigen there is still comparatively little basic inf creation available on the protein, lipid and carbohydrate composition of these …
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Roles of Interferon Lambda on Hepatitis B Virus Replication
"Background/Aims: Chronic hepatitis B virus (HBV) infection is a major cause of liver disease. Only interferon-α (IFN-α) and the nucleosidic inhibitors of the viral polymerase, lamivudine and adefovir, are approved for therapy. However, these therapies are limited by the side effects of interferon …
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Genomic profiling and perturbation of Hepatitis B virus infection
The Hepatitis B virus (HBV) has, at one time or another, infected one third of the world's population, and over 300 million people worldwide are chronically infected, leading often to progressive liver damage, cirrhosis, and the development of hepatocellular carcinoma over decades. While an …
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The Role of e-Antigen in Hepatitis B Infection
… years. In virology, particularly in the study of hepatitis B virus, mathematical models were used to explain interactions between hepatitis B virus and the human host in the absence and presence of interventions such as drug therapy and vaccines. This thesis seeks to explain the role of e-Antigen, …
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Immune Control of Hepatitis B Virus infection by innate lymphocytes
Hepatitis B virus (HBV) infects over 300 million people worldwide and despite the availability of a vaccine, it remains the second biggest carcinogen in the world and a serious global health problem. The majority of adult infections are resolved while 90% of neonates fail to clear infection. …
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Kartierung von umhüllungsrelevanten Aminosäureresten auf dem Hepatitis B Virus Kapsid
… gibt derzeit noch keine Zelllinie, die sich mit Hepatitis-B-Viren infizieren lässt. Der hierfür notwendige HBV-Rezeptor ist bisher noch unbekannt. Jedoch führt die Transfektion von viralem Genom in Leberzellen zur Bildung von infektiösen Virionen, so dass anzunehmen ist, dass die frühen Prozesse …
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Developing a novel hepatitis B core – based antigen presentation system
… a tandem fusion of the core antigen (HBcAg) of hepatitis B virus (HBV) could direct the formation of core-like particles (CLPs) in plants. The work presented here demonstrated that the tandem core system is better suited for the plant-based production of CLPs presenting foreign antigens than …
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Relationship between Hepatitis B Virus Core Particles and Intracellular Motility
PURPOSE: Hepatitis B virus (HBV) core particles recycle back to the nucleus. This recycling mechanism is thought to be important in maintaining covalently closed circular (cccDNA) pool in the nucleus. Transport of HBV core particles in host cytoplasm is important for HBV life cycle but the …
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Expression and Functional Analysis of Hepatitis B Virus DNA Polymerase
… of chimeric DNA polymerase of human and duck hepatitis B virus Hepatitis B Virus (HBV) DNA polymerase is a multifunctional protein with four domains, terminal protein (TP), spacer, reverse transcriptase (RT), and RNaseH. Since HBV DNA polymerase is very unstable and rapidly degradable, it has …
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Clonal proliferation of hepatocytes during chronic hepatitis B virus infection.
Chronic hepatitis B virus (HBV) infection causes liver disease that can progress to cirrhosis and hepatocellular carcinoma (HCC). Changes in the hepatocyte population that occur from the early immune-tolerant stage of infection to late-stage disease outcomes remain unclear. We hypothesised that …
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Mathematical Models of Hepatitis B Virus Dynamics during Antiviral Therapy
Antiviral therapy for patients infected with hepatitis B virus is only partially efficient. The field is in high demand for understanding the connections between the virus, immune responses, short-term and long-term drug efficacy and the overall health of the liver. A mathematical model was …
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Strategies for the induction of mucosal immunity against hepatitis B virus.
… of administration of plasmid DNA encoding the hepatitis B surface antigen (HBsAg) influences the strength and nature of immune responses in mice and non-human primates. Mucosal immunization using plasmid DNA in saline results in no or weak immune responses. Formulation of DNA with lipid …
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