Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Hepatische Sternzellen"”.
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Expression and Regulation of the Insulin-like Growth Factor Axis Components in Rat Liver Myofibroblasts
Hepatische Sternzellen (HSC) und Lebermyofibroblasten (LMF) sind maßgeblich an der Leberfibrogenese beteiligt. Untersuchungen der letzten Jahre weisen darauf hin, dass HSC - im Gegensatz zu LMF - parallel mit ihrer Aktivierung der spontanen Apoptose unterliegen. LMF sind daher von zentraler …
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Unterschiede in der TGF-[beta]-vermittelten Signaltransduktion in aktivierten hepatischen Sternzellen unterhalb der Smad2-Phosphorylierung
TGF-beta is a multifunctional cytokine, that regulates cell proliferation, differentiation, and extracellular matrix production. A profibrogenic role of TGF-beta is postulated, but pathways targeting the TGF-beta response to specific gene activities involved in phenotypic changes of hepatic …
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Kryokonservierung von hepatischen Sternzellen der Ratte
In this work a protocoll for the cryopreservation of rat hepatic stellate cells was developed. Isolated HSC of the rat are used as a model of liver fibrogenesis. Many proceedings are studied on this cells, for example the biotransformation, the gene expression, the effect of pharmaceuticals, …
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Silencing of endoglin in rat hepatic stellate cells by RNA interference identifies endoglin as an important component of the transdifferentiation process
The main purpose of this doctoral thesis was the functional characterization of endoglin in hepatic stellate cells (HSC). This characterization was performed particularly with regard to the impact and the function of endoglin in the transdifferentiation process of HSC into myofibroblast-like cells …