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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"Hepatic lipid metabolism"”.
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Hepatic Lipid metabolism in Neonatal Pigs
… the amount of MCFA in the formula relieved hepatic steatosis however, only removing the MCFA source entirely from the diet lowered the steatosis below 20% of liver weight. Isolated mitochondria from pigs fed high MCFA formula were unable to oxidize pyruvate and malate as effectively as pigs …
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The Role of Akt2 in Hepatic Lipid Metabolism
… ingestion, regulating both carbohydrate and lipid metabolism. When insulin resistance occurs in Type 2 Diabetes Mellitus, dysregulation of both of these processes ensues, resulting in hyperglycemia and lipid abnormalities. One of the most prevalent morbidities associated with insulin …
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IMPACT OF ACLY GENE SILENCING ON HEPATIC LIPID METABOLISM
… ATP citrato liasi (ACLY) è un enzima chiave del metabolismo lipidico, responsabile della conversione di acetil-CoA citosolico a partire dal citrato mitocondriale. L’acetil-CoA generato costituisce un precursore fondamentale sia per la de novo sintesi degli acidi grassi, attraverso la sua …
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Farnesol-Mediated Regulation Of Hepatic Lipid Metabolism In Heparg Cells
… The endogenous isoprenoid farnesol reduces hepatic TG levels in rodents, and this effect appears to involve at least two nuclear receptors, peroxisome proliferator-activated receptor α and farnesoid X receptor (FXR). However, farnesol’s effects on human hepatic lipid metabolism are currently …
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Hepatic lipid metabolism and peroxisomal beta-oxidation in dairy cows
… and source of dietary energy (carbohydrate or lipid) on liver metabolism, blood metabolites, and production variables.
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Role of Ceramidase in Regulating Hepatic Lipid Metabolism and Whole Body Insulin Sensitivity
… and fibrosis. In recent years, sphingolipids have garnered increasing attention for their role in the development of diabetes and metabolic syndrome. Specifically, the accumulation of ceramides in liver was shown to be associated with both hepatic insulin resistance and NAFLD. We …
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Dissecting The Roles of Trim24 In Regulation of Hepatic Lipid Metabolism and Inflammation
… THE ROLES OF TRIM24 IN REGULATION OF HEPATIC LIPID</strong></p> <p><strong>METABOLISM AND INFLAMMATION</strong></p> <p>Lindsey Cauthen Minter, B.S., B.A.</p> <p>Advisory Professor: Michelle C. Barton, Ph.D.</p> <p>In this dissertation, I report the characterization of a new mouse model …
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Investigating the role of transcription factors Nrf2 and Pparα in hepatic lipid metabolism during fasting
… in NADPH generation, gluconeogenesis, and lipid metabolism, although the true extent of the contribution of Nrf2 in vivo to many of these processes has yet to be fully elucidated. When the Nrf2 gene is disrupted, many genes involved in lipogenesis, which are known to be regulated by Pparα, …
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Modulation of Hepatic Lipid Metabolism by Dietary Fats in Neonatal Pigs: Implications for Steatotic Liver Disease
… based studies to evaluate how dietary lipid composition influences the onset, progression, and metabolic regulation in SLD. In Study Ia, we demonstrated that steatosis develops as early as day 7 in pigs fed medium-chain fatty acid (MCFA)-rich formulas and rapidly progresses to …
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HEPATIC LIPID METABOLISM: THE ROLES OF ACAT2 AND ABCG5/G8 IN THE DEVELOPMENT AND PREVENTION OF DISEASE
… dissertation describes a role for ACAT2 and the hepatic ACAT2-derived cholesteryl esters (CE) in hepatic triglyceride metabolism. Data are presented which indicate that CE can limit the mobilization of triglyceride from the liver and lead to hepatic steatosis associated with non-alcoholic fatty …
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The Influence of Adenoviral Infection and the Group VIA Calcium-Independent Phospholipase A2 on Hepatic Lipid Metabolism
… factors that regulate genes involved in lipid metabolism especially in the liver. Therefore, hepatic SREBP is significant regulator of systemic lipid metabolism. Evidence demonstrates that insulin and dietary unsaturated fatty acid (UFA) regulate SREBP1 expression and subsequent …
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THE ROLE OF HEPATIC ACAT2 AND MTP IN HEPATIC CHOLESTERYL ESTER AND TRIGLYCERIDE METABOLISM
Hepatic lipid metabolism plays a major role in non-alcoholic fatty liver disease (NAFLD) and atherosclerosis. The primary goal of this work was to delineate the role of the hepatic cholesterol-esterifying enzyme acyl-CoA:cholesterol acyltransferase 2 (ACAT2) in cholesterol balance and triglyceride …
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AAV9-mediated (Pro)renin Receptor Antagonism Reduces High Fat Diet Induced Hyperglycemia and Hepatic Steatosis in Mouse Model of Non-alcoholic Fatty Liver Disease
… worldwide. It has been associated with impaired metabolism and increased accumulation of triglyceride (TG) in the liver, most of which is derived from exogenous sources including diet. Recent studies showed involvement of (pro)renin receptor (PRR) in various pathways of lipoprotein and energy …
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Adiponectin deficiency leads to hepatic steatosis and contributes to the development of gestational diabetes mellitus
… sensitivity. Since adiponectin has a role in hepatic lipid metabolism, we hypothesize that adiponectin deficiency leads to fatty liver during pregnancy, worsening insulin resistance and contributing to GDM development. We compared adiponectin KO (strain B6;129-Adipoqtm1Chan/J) mice to WT …
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Novel Roles of GLP-1 and GLP-2 in the Regulation of Hepatic Lipid/Lipoprotein Homeostasis and the Involvement of BAT Activation
… disease (NAFLD) and an atherogenic fasting dyslipidemic profile, primarily due to increases in hepatic very low density lipoprotein (VLDL) production. Recent studies have implicated neuronal signalling in the control of hepatic lipid metabolism and VLDL production. The gut derived hormones …
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Dietary broccoli impedes Western diet-enhanced fatty liver and hepatocellular carcinoma development
… a balance between carbohydrate and fat metabolism. The “Westernized” dietary pattern, which is known for high saturated fat and refined sugar and rooted in the lifestyle of a large proportion of the world’s population, may greatly disrupt energy balance, resulting in obesity and …
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Peripartal Lipid Metabolism and Tissue Fatty Acid Composition in Holstein Cows Fed Supplemental Fat During the Dry Period
Our laboratory showed marked decreases in hepatic lipid accumulation at calving after attempting to add BCS by feeding fat to dry cows. Results were confounded; feeding supplemental fat to dry cows was associated with lower DMI and BCS loss. Consequently, 36 cows were fed high-grain or …
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Dry Period Nutrition and Hepatic Metabolism of Fatty Acids and Glucose in Transition Dairy Cows
… of far-off and close-up diets on palmitate metabolism in vitro. During the far-off period, d -60 to -25, cows received a low energy control diet fed ad libitum (100NRC) to meet National Research Council (2001) nutrient requirements, a moderate-energy diet fed ad libitum to exceed NRC …
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Physiological and molecular mechanisms associated with performance, immunometabolic status, and liver function in transition dairy cows fed rumen protected methionine or choline
… this time may be limiting for milk production, hepatic lipid metabolism, and immune function. Supplementing rumen-protected MET and CHOL may improve overall performance and health of transition cows. Physiological and molecular mechanisms for methyl donor supplementation benefits are unknown. …
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