Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Hepatic inflammation"”.
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Follow your gut: Does AKR1D1 impact gastrointestinal health?
… intestinal barrier function and inducing hepatic inflammation. We have previously shown that expression of the bile acid synthesis enzyme 5β-reductase (AKR1D1) is decreased in patients with NAFLD. In this thesis, I have examined the impact of AKR1D1 deletion on intestinal barrier function …
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An investigation of genome-wide promoter region cytosine-phosphate-guanine (CpG) Island methylation profiles in patients with chronic hepatitis B virus infection
… and result in the clinical disease phenotypes of hepatic inflammation, fibrosis and HCC that characterise chronic HBV infection. Genome-wide microarray analysis was used to investigate for the presence of promoter CpG island methylation in a cohort of patients with liver disease due to HBV …
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Β-carotene promotes atherosclerosis resolution and alleviates liver inflammation in a reversible murine model of atherosclerosis: A potential role of regulatory T cells
… of β-carotene on atherosclerosis regression and hepatic inflammation. Methods: We utilized various animal models to study atherosclerosis regression: In our first model, we used weekly injections of an antisense oligonucleotide targeting the expression of the low-density lipoprotein receptor …
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The Role of the Complement System in Mousepox Infection
… the congenic controls. Specifically, increased hepatic inflammation and necrosis correlated with these higher tissue titers and likely contributed to the morbidity in the C3<super>-/-</super> mice. In vitro, the complement system in na├»ve C57BL/6 mouse sera neutralized ectromelia virus, …
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Induction and Regulation of CXCL10 in Hepatocytes During Hepatitis C Virus Infection
… (IFN)-based therapies. Since persistent hepatic inflammation can lead to degenerative liver disease, this work sought to evaluate how innate immune sensors of HCV infection (Toll-like receptor 3 [TLR3] and retinoic acid inducible gene I [RIG-I]) contribute to CXCL10 induction in …