Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Hepatic inflammation"”.
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Follow your gut: Does AKR1D1 impact gastrointestinal health?
… intestinal barrier function and inducing hepatic inflammation. We have previously shown that expression of the bile acid synthesis enzyme 5β-reductase (AKR1D1) is decreased in patients with NAFLD. In this thesis, I have examined the impact of AKR1D1 deletion on intestinal barrier function …
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An investigation of genome-wide promoter region cytosine-phosphate-guanine (CpG) Island methylation profiles in patients with chronic hepatitis B virus infection
… and result in the clinical disease phenotypes of hepatic inflammation, fibrosis and HCC that characterise chronic HBV infection. Genome-wide microarray analysis was used to investigate for the presence of promoter CpG island methylation in a cohort of patients with liver disease due to HBV …
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Β-carotene promotes atherosclerosis resolution and alleviates liver inflammation in a reversible murine model of atherosclerosis: A potential role of regulatory T cells
… of β-carotene on atherosclerosis regression and hepatic inflammation. Methods: We utilized various animal models to study atherosclerosis regression: In our first model, we used weekly injections of an antisense oligonucleotide targeting the expression of the low-density lipoprotein receptor …
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Heterozygote Hämochromatose-Genmutationen als genetische Progressionsfaktoren bei chronischer Hepatitis C
… C is frequently associated with increased hepatic iron stores. It remains controversial whether heterozygous mutations of hemochromatosis genes affect fibrosis progression. Therefore our aim was to assess associations between HFE mutations and hepatic inflammation and stage of fibrosis in …
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The Role of the Complement System in Mousepox Infection
… the congenic controls. Specifically, increased hepatic inflammation and necrosis correlated with these higher tissue titers and likely contributed to the morbidity in the C3<super>-/-</super> mice. In vitro, the complement system in na├»ve C57BL/6 mouse sera neutralized ectromelia virus, …
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Induction and Regulation of CXCL10 in Hepatocytes During Hepatitis C Virus Infection
… (IFN)-based therapies. Since persistent hepatic inflammation can lead to degenerative liver disease, this work sought to evaluate how innate immune sensors of HCV infection (Toll-like receptor 3 [TLR3] and retinoic acid inducible gene I [RIG-I]) contribute to CXCL10 induction in …
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The function of TAK1 in hepatocarcinogenesis
… that TAK1 prevents liver cell apoptosis and hepatic inflammation since it is necessary for NF-kappaB activation but not JNK activation in response to LPS stimulation, a potent inducer of TNF secretion from non-parenchymal liver cells. However, qRT-PCR analysis revealed that ablation of TAK1 …