Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 17 of 17 for “"Hepatic Fibrosis"”.
-
Liver stiffness measurement for the diagnosis of hepatic fibrosis in patients with chronic viral hepatitis
"목적: FibroScan？瑛？ 간의 경직성을 측정하여 비침습적으로 간의 섬유화 정도를 진단하는 검사로, 만성 바이러스성 간염 환자를 대상으로 검사의 유용성 여부 확인을 위해 연구를 시행하였다. 방법: 2005년 10월부터 2006년 8월까지 FibroScan？怜？ 간조직검사 를 시행한 만성 B형, C형 간염환자 103명을 분석하였으며, 간조직검사 결과는 대한병리학 회 기준에 따라 0 ~ 4단계로 분류하였다. 결과: 간의 탄력도는 3.5-57.1kPa (평균: 11.8, 표준편차: 8.9)이었고, 간섬유화 정도에 따른 간탄력도의 …
-
EFFECT OF COMBINATION OF THE MAMMALIAN LIGNAN, ENTEROLACTONE, WITH TYROSINE KINASE INHIBITORS ON MARKERS OF HEPATIC FIBROSIS
Current treatments for hepatic fibrosis are still elusive because of the lack of efficient and safe drugs. The pathogenesis of hepatic fibrosis suggests multi-target drugs might have therapeutic potential. This dissertation research aimed to confirm the antifibrotic effects of the combination of …
-
Mechanistic Elucidation of the Function of Sirtuin 6 in the Regulation of Liver Fibrosis
Hepatic fibrosis is a cellular repair mechanism that is initiated upon prolonged damage to the liver, resulting in an accumulation of excess extracellular matrix. This eventually leads to the formation of scar tissue, which disrupts the hepatic architecture and causes liver dysfunction. Hepatic …
-
HEPATIC DIFFERENTIATION OF HUMAN AMNIOTIC EPITHELIAL CELLS AND IN VIVO THERAPEUTIC EFFECT ON ANIMAL MODEL OF CIRRHOSIS
… FOR HEPATOCYTE DERIVATION. AFTER IN VITRO HEPATIC DIFFERENTIATION, HAEC-HEP CELLS SHOWED DIFFERENTIAL REGULATION IN GENES INVOLVED IN LIVER FUNCTION, CYP450 ACTIVITIES AND LIVER TRANSCRIPTION FACTORS. IMMUNOFLUORESCENCE STAINING SHOWED POSITIVITY FOR LIVER SPECIFIC MARKERS. FUNCTIONALLY, …
-
Physiology and Pathophysiology of Retinoid and Lipid Storage in Mouse Hepatic Stellate Cell Lipid Droplets
… and, of this fraction, 80-90% is stored in the hepatic stellate cell (HSC) lipid droplets as retinyl ester. These lipid droplets are a distinguishing feature of the HSC, and they have recently been proposed to be specialized organelles for the storage of retinoid based on their unique retinoid …
-
Splenic and portal venography
… with a block inside the liver, the result of hepatic fibrosis. The cases with extrahepatic blockage of the portal circulation present clinically as cases of Banti's Syndrome. In this latter group repeated haematemeses are a common, and often fatal symptom. The operation of portacaval …
-
Development and Evaluation of Nano‑scale Systems for Targeted Delivery to Treat Liver Fibrosis
… of ECM is the common characteristic of liver fibrosis. During hepatic fibrosis, various inflammatory cytokines are released and trigger the activation of quiescent HSCs. The activated HSCs play the major role in producing extra amount collagen. It becomes very crucial to focus on HSCs to find …
-
Biliary atresia at Red Cross War Memorial Children's Hospital: A retrospective descriptive study reviewing the age of presentation, clinical course and outcome of infants presenting to RCWMCH with biliary atresia
… If left untreated it rapidly progresses to hepatic fibrosis and cirrhosis, with death occurring within 2 years. It is the leading cause of end-stage liver disease in the paediatric population and remains the most common indication for paediatric liver transplantation in South Africa. …
-
Using Statistical Techniques and Machine Learning to Assess Potential Biomarkers and Clinical Characteristics for Differences between Chronic Hepatitis C Virus and Hepatocellular Carcinoma
… (acute) to lifelong liver injury resulting in fibrosis (chronic). Approximately 75%–85% of people infected with hepatitis C virus will progress to chronic infection. Chronic hepatitis C causes the liver to progress through stages of fibrosis. Patients with stage IV hepatic fibrosis can progress …
-
Acoustical-molecular techniques for magnetic resonance imaging
… acoustic stimulation as model systems. We imaged hepatic fibrosis in a rat model and found that collagen-binding paramagnetic contrast agents and shear wave MR elastography had partially uncorrelated staging abilities, due to the disease condition's differential timing of collagen production and …
-
An in vivo study of novel genetic modifiers in autosomal recessive polycystic kidney disease (ARPKD)
… with bilaterally enlarged, cystic kidneys, hepatic fibrosis and pulmonary hypoplasia, with death reported in around 30 – 50% of affected neonates. Mutations in PKHD1 and DZIP1L have been identified as causative genes for ARPKD, with the protein products of both genes localising to the …
-
Machine learning and data analytics for liver disease modeling
… disease characterized by bile duct inflammation, hepatic fibrosis, and a markedly increased risk of malignancy. Despite its severity, the underlying pathophysiology of PSC remains incompletely understood, and effective medical therapies remain lacking. This dissertation addresses challenges in …
-
T-lymphocyte senescence and hepatitis C virus infection
… and hepatocellular carcinoma. The degree of fibrosis progression and treatment-related outcomes are critically dependent on the age of the infected individual. Progressive ageing is associated with a decline in the efficacy of adaptive immune system function. T-lymphocytes from aged subjects …
-
Bone morphogenetic proteins 9 & 10 in pulmonary arterial hypertension
… BMP9 deficiency is reported to protect against hepatic fibrosis and damage after inducement with severe surgical and chemical interventions. In contrast, BMP9 deficient animals do not appear to develop a phenotype reminiscent of PAH. Recently, the Morrell group discovered loss-of-function …
-
Hepatic stellate cell heterogeneity and function during the hepatic regenerative response
… the Western world1 and results in centrilobular hepatic necrosis. In non-severe cases the liver regenerates to normal microarchitecture and function. However, in severe APAP-induced ALF, transplantation remains the only curative treatment. Hepatic stellate cells (HSCs) play a central role during …
-
Role of simple biomarkers in predicting fibrosis progression in HCV infection
Hepatic fibrosis biomarkers have been found to be variably accurate in the estimation of fibrosis in chronic Hepatitis C hepatitis (HCV). There is little information whether they are useful longitudinal predictors of changes of fibrosis stage; i.e., progression of fibrosis to cirrhosis. The aim of …