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Showing 1 to 20 of 23 for “"Hepatic Fibrosis"”.

  1. Liver stiffness measurement for the diagnosis of hepatic fibrosis in patients with chronic viral hepatitis

    강, 준구2011

    "목적: FibroScan？瑛？ 간의 경직성을 측정하여 비침습적으로 간의 섬유화 정도를 진단하는 검사로, 만성 바이러스성 간염 환자를 대상으로 검사의 유용성 여부 확인을 위해 연구를 시행하였다. 방법: 2005년 10월부터 2006년 8월까지 FibroScan？怜？ 간조직검사 를 시행한 만성 B형, C형 간염환자 103명을 분석하였으며, 간조직검사 결과는 대한병리학 회 기준에 따라 0 ~ 4단계로 분류하였다. 결과: 간의 탄력도는 3.5-57.1kPa (평균: 11.8, 표준편차: 8.9)이었고, 간섬유화 정도에 따른 간탄력도의 …

    ajou Repository record

  2. EFFECT OF COMBINATION OF THE MAMMALIAN LIGNAN, ENTEROLACTONE, WITH TYROSINE KINASE INHIBITORS ON MARKERS OF HEPATIC FIBROSIS

    Yang, XiaoleiUniversity of Saskatchewan2021

    Current treatments for hepatic fibrosis are still elusive because of the lack of efficient and safe drugs. The pathogenesis of hepatic fibrosis suggests multi-target drugs might have therapeutic potential. This dissertation research aimed to confirm the antifibrotic effects of the combination of …

    sask Repository record

  3. Mechanistic Elucidation of the Function of Sirtuin 6 in the Regulation of Liver Fibrosis

    Chowdhury, Kushan2022

    Hepatic fibrosis is a cellular repair mechanism that is initiated upon prolonged damage to the liver, resulting in an accumulation of excess extracellular matrix. This eventually leads to the formation of scar tissue, which disrupts the hepatic architecture and causes liver dysfunction. Hepatic …

    iupui Repository record

  4. Heterozygote Hämochromatose-Genmutationen als genetische Progressionsfaktoren bei chronischer Hepatitis C

    Reugels, Michael JosefPublikationsserver der RWTH Aachen University2004

    … C is frequently associated with increased hepatic iron stores. It remains controversial whether heterozygous mutations of hemochromatosis genes affect fibrosis progression. Therefore our aim was to assess associations between HFE mutations and hepatic inflammation and stage of fibrosis in …

    aachen Repository record

  5. Assoziation zwischen vier Polymorphismen des menschlichen Transforming-Growth-Factor-beta1-Gens und der zeitlichen Progression der posthepatitischen Leberfibrose

    Gewaltig, JanPublikationsserver der RWTH Aachen University2003

    … and progression rate (METAVIR-score) of liver fibrosis. Methods: Three study groups, i.e. 48 patients with hepatic fibrosis (26 with known duration of hepatitis C virus infection), 47 patients with non-fibrotic diseases and 50 healthy blood donors, were analyzed for TGF-beta1 polymorphisms …

    aachen Repository record

  6. HEPATIC DIFFERENTIATION OF HUMAN AMNIOTIC EPITHELIAL CELLS AND IN VIVO THERAPEUTIC EFFECT ON ANIMAL MODEL OF CIRRHOSIS

    LIN SIQI JAYMIE2014

    … FOR HEPATOCYTE DERIVATION. AFTER IN VITRO HEPATIC DIFFERENTIATION, HAEC-HEP CELLS SHOWED DIFFERENTIAL REGULATION IN GENES INVOLVED IN LIVER FUNCTION, CYP450 ACTIVITIES AND LIVER TRANSCRIPTION FACTORS. IMMUNOFLUORESCENCE STAINING SHOWED POSITIVITY FOR LIVER SPECIFIC MARKERS. FUNCTIONALLY, …

    nus Repository record

  7. Identifizierung und Charakterisierung von Pkhd1, dem Maus-Ortholog des humanen ARPKD-Gens, sowie Erstellung und Analyse einer Pkhdl mutierten Maus

    Matthiesen, SonjaPublikationsserver der RWTH Aachen University2003

    … renal cysts, biliary dysgenesis and congenital hepatic fibrosis due to ductal plate malformation. With an estimated incidence of 1 in 20,000 up to 50% of the affected neonates die shortly after birth. ARPKD is caused by mutations in a single gene (Pkhd1, polycystic kidney and hepatic disease 1) …

    aachen Repository record

  8. Physiology and Pathophysiology of Retinoid and Lipid Storage in Mouse Hepatic Stellate Cell Lipid Droplets

    D'Ambrosio, Diana N.2011

    … and, of this fraction, 80-90% is stored in the hepatic stellate cell (HSC) lipid droplets as retinyl ester. These lipid droplets are a distinguishing feature of the HSC, and they have recently been proposed to be specialized organelles for the storage of retinoid based on their unique retinoid …

    columbia-diss Repository record

  9. Splenic and portal venography

    Dreyer, Barend Jansen van RensburgDivision of Physiological Sciences1952

    … with a block inside the liver, the result of hepatic fibrosis. The cases with extrahepatic blockage of the portal circulation present clinically as cases of Banti's Syndrome. In this latter group repeated haematemeses are a common, and often fatal symptom. The operation of portacaval …

    cape-town Repository record

  10. Development and Evaluation of Nano‑scale Systems for Targeted Delivery to Treat Liver Fibrosis

    Yang, Ningning2016

    … of ECM is the common characteristic of liver fibrosis. During hepatic fibrosis, various inflammatory cytokines are released and trigger the activation of quiescent HSCs. The activated HSCs play the major role in producing extra amount collagen. It becomes very crucial to focus on HSCs to find …

    tenn-hsc Repository record

  11. Biliary atresia at Red Cross War Memorial Children's Hospital: A retrospective descriptive study reviewing the age of presentation, clinical course and outcome of infants presenting to RCWMCH with biliary atresia

    Levin, Lindsey NicolaDepartment of Paediatrics and Child Health2016

    … If left untreated it rapidly progresses to hepatic fibrosis and cirrhosis, with death occurring within 2 years. It is the leading cause of end-stage liver disease in the paediatric population and remains the most common indication for paediatric liver transplantation in South Africa. …

    cape-town Repository record

  12. Using Statistical Techniques and Machine Learning to Assess Potential Biomarkers and Clinical Characteristics for Differences between Chronic Hepatitis C Virus and Hepatocellular Carcinoma

    Bailey, Christine NicoleThe University of Texas Medical Branch at Galveston2022

    … (acute) to lifelong liver injury resulting in fibrosis (chronic). Approximately 75%–85% of people infected with hepatitis C virus will progress to chronic infection. Chronic hepatitis C causes the liver to progress through stages of fibrosis. Patients with stage IV hepatic fibrosis can progress …

    utmb Repository record

  13. Untersuchung der relativen Serum-Trisialotransferrin-Konzentration als möglicher prädiktiver Biomarker für hepatozelluläre Dedifferenzierung bei chronisch fibrogener Lebererkrankung

    Jafari, ShadiPublikationsserver der RWTH Aachen University2009

    … (70%-80%). Chronic hepatitis induced liver fibrosis is characterized by epithelial-to-mesenchymal transition of liver parenchymal cells (hepatocytes) to fibroblast (-like cells), i.e. increasing hepatocellular dedifferentiation, ultimatively leading to the development of hepatocellular …

    aachen Repository record

  14. Acoustical-molecular techniques for magnetic resonance imaging

    Zhu, Bo, Ph. D. Massachusetts Institute of TechnologyMassachusetts Institute of Technology2016

    … acoustic stimulation as model systems. We imaged hepatic fibrosis in a rat model and found that collagen-binding paramagnetic contrast agents and shear wave MR elastography had partially uncorrelated staging abilities, due to the disease condition's differential timing of collagen production and …

    mit Repository record

  15. An in vivo study of novel genetic modifiers in autosomal recessive polycystic kidney disease (ARPKD)

    Malik, Soniya ArshadUniversity of Wolverhampton2025

    … with bilaterally enlarged, cystic kidneys, hepatic fibrosis and pulmonary hypoplasia, with death reported in around 30 – 50% of affected neonates. Mutations in PKHD1 and DZIP1L have been identified as causative genes for ARPKD, with the protein products of both genes localising to the …

    wlv Repository record

  16. Machine learning and data analytics for liver disease modeling

    Hu, ChangUniversity of Illinois Urbana-Champaign2025

    … disease characterized by bile duct inflammation, hepatic fibrosis, and a markedly increased risk of malignancy. Despite its severity, the underlying pathophysiology of PSC remains incompletely understood, and effective medical therapies remain lacking. This dissertation addresses challenges in …

    uiuc Repository record

  17. T-lymphocyte senescence and hepatitis C virus infection

    Hoare, MatthewUniversity of Cambridge2010

    … and hepatocellular carcinoma. The degree of fibrosis progression and treatment-related outcomes are critically dependent on the age of the infected individual. Progressive ageing is associated with a decline in the efficacy of adaptive immune system function. T-lymphocytes from aged subjects …

    cambridge Repository record

  18. Role of monocyte subsets in chronic liver injury and liver fibrosis

    Karlmark, Karlin RajaPublikationsserver der RWTH Aachen University2009

    … and CCR2-Gr-1low monocytes, respectively. Liver fibrosis is the consequence of chronic liver inflammation, which is characterized by the accumulation of extracellular matrix proteins such as collagen-I. Patients with liver fibrosis are at high risk of developing liver cirrhosis or hepatocellular …

    aachen Repository record

  19. Bone morphogenetic proteins 9 & 10 in pulmonary arterial hypertension

    Hodgson, JoshuaUniversity of Cambridge2019

    … BMP9 deficiency is reported to protect against hepatic fibrosis and damage after inducement with severe surgical and chemical interventions. In contrast, BMP9 deficient animals do not appear to develop a phenotype reminiscent of PAH. Recently, the Morrell group discovered loss-of-function …

    cambridge Repository record

  20. Einfluss von Transforming Growth Factor-beta1 (TGF-[beta]1) Genpolymorphismen auf die Hepatitis-C-induzierte Leberfibrose in vivo und Modulation der TGF-[beta]1-Synthese, Prozessierung und Sekretion durch die Serin-Protease Furin, das latent TGF-[beta] binding protein-1 und Polymorphismen der TGF-[beta]1-Signalsequenz in vitro

    Mohren, SimonePublikationsserver der RWTH Aachen University2008

    … 25 and codon 263 on hepatitis C induced liver fibrosis was analysed. For that purpose, liver needle biopsies from 430 patients suffering from chronic hepatitis C infection were scored for the necroinflammatory activity (grading) and degree of hepatic fibrosis (staging). Protocols allowing the …

    aachen Repository record

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