Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 263 for “"Heparin"”.
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MOLECULAR MODELING STUDIES OF HEPARIN AND HEPARIN MIMETICS BINDING TO COAGULATION PROTEINS
<p>Heparin, a glycosaminoglycan (GAG), is a complex biopolymer of varying chain length and consisting of uronic acid and glucosamine residues, which are sulfated at various positions. The interaction of heparin with antithrombin is the basis for anticoagulation therapy. Heparin accelerates the …
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The role of heparin and heparin-binding growth factors in pre-eclampsia
… study tested the hypothesis that expression of heparin-binding growth factors (HBGFs) in normal placental development was altered in a specific pregnancy disorder preeclampsia. HBGFs bind to heparin, a glycosaminoglycan (GAG) affecting activity. I investigated the role of heparin and HBGFs in …
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A system for heparin removal
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1985.
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STUDIES ON COMPLEX FORMATION BY HEPARIN
The work describes the preparation of a cobalt-heparin complex and the study of its properties, which included the analysis of elements, saccharide components, and biological and chemical assays. The bioactivity of this compound has been determined using both in. vivo and in vitro assays. In …
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Structure and Metabolism of Heparin and Heparan Sulfate
Heparin was selectively cleaved at N-sulfoglucosamine residues by treatment with nitrous acid at pH 1.5. The oligosaccharide products, primarily disaccharides and tetrasaccharides, were then end-labeled by reduction with sodium borotritide and purified to homogeneity using a combination of BioGel …
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Structural Analysis of Reconstituted Collagen Type I - Heparin Cofibrils
… ECM components like collagen type I and the GAG heparin, is presented here. Although the individual components comply with the adhesive, mechanical and bioinductive requirements for artificial reconstituted ECMs, their interaction and structural characterization remains an intriguing conundrum. …
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Coaxially electrospun heparin-eluting scaffolds for vascular graft application
… grafts have high failure rates. The inclusion of heparin into such scaffolds can be beneficial for vascular graft applications as it could prevent mid-graft thrombosis, stabilise and potentiate growth factors as well as subdue undue proliferation of smooth muscle cells. Previous attempts at …
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Synthesizing a Heparin Mimic Material Derived from Cellulose Nanocrystals
To prevent clotting during dialysis, heparin is used to line the tubing which blood flows through. Unfortunately, many side effects arise from taking heparin, especially when it is used for an extended period of time. As such, long-term exposure for individuals undergoing dialysis every day is …
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Investigations into therapeutic discovery and delivery of heparin-like glycosaminoglycans
Heparin-like glycosaminoglycans (HLGAGs) are complex polysaccharides found both in extracellular matrix (ECM) and at the cell surface where they, in a sequence-specific manner, bind to and regulate the biological activity of numerous proteins. Due to a lack of effective tools to study …
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Skeletal Muscle and Post-Heparin Plasma Lipoprotein Lipase Activities (Exercise, Triglyceride)
… of skeletal muscles and adipose tissue, and post-heparin plasma (PHP) in rats using experimental conditions of diet and exercise. Starvation decreased adipose tissue LPL activity, but had little effect on muscles. Refeeding stimulated activity in adipose tissue by +300%. High-carbohydrate feeding …
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A peptide model for the heparin binding site on Antithrombin III
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 1992
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Uterine Remodeling During Pregnancy - Studies on the Effect of Heparin/Heparan Sulfate
… before parturition, as shown by the finding that heparin fragments can be used in a clinical setting to prevent protracted labor.
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Mass spectrometric and capillary electrophoretic investigation of heparin, heparinases, and related compounds
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1998.
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Innovative Purification Protocol for Heparin Binding Proteins: Relevance in Biopharmaceutical and Biomedical Applications
<p>Heparin binding (HB) proteins mediates a wide range of important cellular processes, which makes this class of proteins biopharmaceutically important. Engineering HB proteins could bring many advantages, but it necessitates cost effective and efficient purification methodologies compared to the …
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Economic Evaluation of Anticoagulation with Bivalirudin vs. Heparin during Pediatric Extracorporeal Membrane Oxygenation
… immature clotting cascades. While heparin has traditionally been used for anticoagulation during ECMO, there is new interest in Bivalirudin, an alternate anticoagulant. Bivalirudin has a different mechanism of action with potential benefits of more consistent therapeutic effect and …
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