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Showing 1 to 20 of 92 for “"Heparan sulfate"”.
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Heparan sulfate glycosaminoglycan regulation of vasculogenesis
… microenvironment in stem cell differentiation. Heparan sulfate glycosaminoglycans (HSGAG) are a crucial part of the dynamic extracellular matrix and have been shown to regulate multiple signaling cascades, including vasculogenic specific growth factors VEGF and FGF. The goal of this thesis is to …
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Heparan Sulfate Proteoglycans in Pancreatic Ductal Adenocarcinoma (PDAC)
<p>We have previously identified a heparan sulfate proteoglycan (HSPG), Syndecan-1 (SDC1), as a key effector for pancreatic ductal adenocarcinoma (PDAC) progression whose surface expression is driven by KRAS*. By leveraging various PDAC models, we found that surface SDC1 expression was initially …
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Structure and Metabolism of Heparin and Heparan Sulfate
Heparin was selectively cleaved at N-sulfoglucosamine residues by treatment with nitrous acid at pH 1.5. The oligosaccharide products, primarily disaccharides and tetrasaccharides, were then end-labeled by reduction with sodium borotritide and purified to homogeneity using a combination of BioGel …
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The Heparan Sulfate Proteoglycan Perlecan Regulates Axonal and Synaptic Stability
Heparan sulfate proteoglycans (HSPGs) form essential components of the extracellular matrix (ECM) and basement membrane (BM) and have both structural and signaling roles. Perlecan is a secreted ECM-localized HSPG that contributes to tissue integrity and cell-cell communication. In this thesis, I …
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Role of the interaction of proHB-EGF with heparan sulfate proteoglycans
… (EGFR), and possesses the ability to bind heparan sulfate proteoglycans (HSPGs). The interaction of HB-EGF with HSPGs has been previously studied only with the soluble (autocrine/paracrine) form of the protein (sHB-EGF), produced after proteolytic cleavage of the transmembrane form …
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Analysis of heparan sulfate function during herpes simplex virus type-1 infection.
Analysis of heparan sulfate function during herpes simplex virus type-1 infection.
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Uterine Remodeling During Pregnancy - Studies on the Effect of Heparin/Heparan Sulfate
… of the uterine cervix preceding labor. Moreover, heparan sulfate proteoglycans appear to be central for the remodeling of the cervix and uterus before parturition, as shown by the finding that heparin fragments can be used in a clinical setting to prevent protracted labor.
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Roles of Heparan sulfate in mesendoderm differentiation of human embryonic stem cells
… and extrinsic signals in the stem cell niche. Heparan sulfate proteoglycans (HSPGs) are found on the membrane of all animal cells and have long been implicated in a wide range of cell-cell signaling and cell-matrix interactions. Multiple heparan sulfate (HS)-binding growth factors, such as Wnt, …
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Heparan sulfate mediated transport of basic fibroblast growth factor through extracellular matrix
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1998.
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Characterization of heparan sulfate proteoglycan receptor from a permanent rat liver cell line
… was undertaken to demonstrate the existence of a heparan sulfate proteoglycan (HSPG) specific receptor on the cell surface of rat liver cell (RLC), and to characterize the specificity of the ligand-receptor interaction, the properties of the receptor, and the importance of the receptor in HSPG …
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Fluorous assisted one-pot oligosaccharide synthesis and chemical synthesis of homogeneous heparan sulfate proteoglycan
… are synthesized using this method. Hpearan sulfate proteoglycans (HSPGs), including syndecans and glypicans, are ubiquitous components of mammalian cell surface and extracellular matrix and they play important roles in various biological processes such as cancer development, angiogenesis. …
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Defining the role of heparan sulfate proteoglycans in APL-1 function in Caenorhabditis elegans
… to guide sAPL-1 to its target receptors. Heparin sulfate proteoglycans (HSPGs), such as LON-2 glypican and UNC-52 perlecan, are likely candidates for the ECM proteins that interact and guide sAPL-1. The disruption of APL-1 causes phenotypical changes, including in learning, reproduction, and …
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Correlation of Heparan Sulfate Proteoglycan Structure and Metabolism With the Regulation of Cell Division
Heparan sulfate proteoglycan (HSPG), a ubiquitous cell surface component in animal cells, is a complex, polyanionic macromolecule consisting of a core protein to which are attached several heparan sulfate (HS) chains. Growing and confluent cultures of a rat hepatocyte cell line were labeled with …
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The role of heparan sulfate proteoglycans and heparanase in the control of vascular remodeling
… atherosclerosis and restenosis. We examined heparan sulfate proteoglycan homeostasis as a mechanism of regulation of arterial vascular remodeling in response to altered mechanical environments such as hypertension and injury. We first studied the effect of in-vitro mechanical strain on the …
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Knockdown of Heparan Sulfate Via NDST1 knockout Does Not Inhibit Mouse Aortic Endothelial Cell Alignment In-Vivo
… into the role of NDST1 sulfation of heparan sulfate (HS), a key component of many proteoglycans which make up the GCX, was conducted. The descending aortas (DAs) of transgenic mice with conditional knockouts (KOs) of NDST1 in vascular ECs were quantified for changes in alignment on …
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Metabolism of Heparan Sulfate Proteoglycan in Rat Hepatocyte Cell Line and Its Role for Regulation of Cell Growth
A rat hepatocyte cell line which accumulates free heparan sulfate (HS) chains in the nucleus was labeled with $\sp{35}$SO$\sb4\sp{2-}$ and the rate of appearance of ($\sp{35}$SO$\sb4$) HS in the nucleus was measured. ($\sp{35}$SO$\sb4$) HS began to accumulate in the nucleus 2 h after the addition …
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Identification, molecular cloning, and characterization of cerebroglycan, a cell surface heparan sulfate proteoglycan of the developing rat brain
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1996.
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CHARACTERIZATION OF THE INTERACTION BETWEEN HEPARAN SULFATE AND THE SPIKE (S) PROTEIN OF THE LATEST SARS-COV-2 VARIANTS
Heparan sulfate is a linear, highly sulfated polysaccharide that belongs to the glycosaminoglycan (GAG) family. The disaccharide repeating unit includes a uronic acid residue (either D-glucuronic or L-iduronic) 1→4 linked to a glucosamine (GlcN). The glucosamine residues can be mono- or …
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