Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Heparan Sulfate Proteoglycans (HSPGs)"”.
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Identification of the receptor for cellular internalization of an anti-nucleic acid antibody, 3D8 scFv
… 3D8 scFv bound to both cell surface heparan sulfate proteoglycans (HSPGs) and chondroitin sulfate proteoglycans (CSPGs) that are highly negatively charged molecules known as endocytic receptors for a variety of ligands. Treatment of soluble HS or CS reduced cell surface binding of 3D8 …
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Roles of Heparan sulfate in mesendoderm differentiation of human embryonic stem cells
… and extrinsic signals in the stem cell niche. Heparan sulfate proteoglycans (HSPGs) are found on the membrane of all animal cells and have long been implicated in a wide range of cell-cell signaling and cell-matrix interactions. Multiple heparan sulfate (HS)-binding growth factors, such as Wnt, …
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Role of the interaction of proHB-EGF with heparan sulfate proteoglycans
… (EGFR), and possesses the ability to bind heparan sulfate proteoglycans (HSPGs). The interaction of HB-EGF with HSPGs has been previously studied only with the soluble (autocrine/paracrine) form of the protein (sHB-EGF), produced after proteolytic cleavage of the transmembrane form …
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The Heparan Sulfate Proteoglycan Perlecan Regulates Axonal and Synaptic Stability
Heparan sulfate proteoglycans (HSPGs) form essential components of the extracellular matrix (ECM) and basement membrane (BM) and have both structural and signaling roles. Perlecan is a secreted ECM-localized HSPG that contributes to tissue integrity and cell-cell communication. In this thesis, I …
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The Role of Stromal-Derived Factors in Neuroblastoma Differentiation
… differentiation and decreased proliferation. Heparan sulfate proteoglycans (HSPGs) and heparin derivatives further enhance HBEGF-induced differentiation by forming a complex with the epidermal growth factor receptor (EGFR), leading to activation of the ERK1/2 and STAT3 pathways and …
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CHARACTERIZATION OF THE INTERACTION BETWEEN HEPARAN SULFATE AND THE SPIKE (S) PROTEIN OF THE LATEST SARS-COV-2 VARIANTS
Heparan sulfate is a linear, highly sulfated polysaccharide that belongs to the glycosaminoglycan (GAG) family. The disaccharide repeating unit includes a uronic acid residue (either D-glucuronic or L-iduronic) 1→4 linked to a glucosamine (GlcN). The glucosamine residues can be mono- or …
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The effect of scaffold physical properties on endothelial cell function
… over a range from 50 Pa- 1500 Pa. Secretion of heparan sulfate proteoglycans (HSPGs), which inhibit smooth muscle cell growth, is maximal at low moduli and flat at high moduli. Secretion of growth factors such as FGF2 and PDGF-BB were also modulus responsive. Inhibition of smooth muscle cell …
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Mechanisms of Molecular Chaperone Surface Binding and Endocytosis: Insights into the Molecular Basis for GRP94 Immune Function
… the course of these studies, cell surface heparan sulfate proteoglycans (HSPGs) were identified as novel cell surface binding sites for GRP94.NTD on MEF cells. This conclusion was established using three distinct experimental approaches. GRP94.NTD surface binding was significantly decreased …
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NOVEL INSIGHTS INTO GENETIC AND ENVIRONMENTAL DETERMINANTS SHAPING GNRH NEURON BIOLOGY AND RELATED REPRODUCTIVE DISORDERS
… role of HS6ST1 and HS6ST2, enzymes that modify heparan sulfate proteoglycans (HSPGs) and thereby regulate the binding of axon guidance molecules like VEGF and SEMA3A. While mutations in HS6ST1 have previously been reported in IGD patients, the role of HS6ST2 remained uncharacterized. Using a …
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Defining the role of heparan sulfate proteoglycans in APL-1 function in Caenorhabditis elegans
… to guide sAPL-1 to its target receptors. Heparin sulfate proteoglycans (HSPGs), such as LON-2 glypican and UNC-52 perlecan, are likely candidates for the ECM proteins that interact and guide sAPL-1. The disruption of APL-1 causes phenotypical changes, including in learning, reproduction, and …
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Expression and Transcriptional Regulation of APL-1, a <i>Caenorhabditis elegans</i> APP Ortholog
… that extracellular matrix proteins, particularly heparan sulfate proteoglycans, are involved in shuttling the extracellular domain sAPL-1 to activate its targets and also towards degradation in the coelomocytes. Finally, we identify genetic factors that control APL-1 expression, and putative …