Global ETD Search
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Showing 1 to 11 of 11 for “"Hepacivirus"”.
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Ρύθμιση της έκφρασης του IRES (εσωτερική θέση πρόσβασης του ριβοσώματος) του ιού της ηπατίτιδας C
… RNA ιός θετικής πολικότητας που ανήκει στο γένος Hepacivirus της οικογένειας των Flaviviridae. Έξι γονότυποι ( 1-6 ) είναι γνωστοί, καθένας από τους οποίους μπορεί να υποδιαιρεθεί περαιτέρω σε αρκετές υποτύπους. Το γονιδίωμα του HCV αποτελείται από ένα μεγάλο ανοικτό πλαίσιο ανάγνωσης (ORF), …
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Assessing and understanding the generation and function of RNA decay intermediates in non-insect borne flaviviruses
… enzyme XRN1. In addition, members of the generas Hepacivirus, Hepatitis C Virus (HCV) and Pestivirus, Bovine Viral Diarrhea Virus (BVDV), possess XRN1 stalling elements within their 5' UTRs. These stalling sites block the action of the exonuclease and generate decay intermediates. The generation …
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Identification of Host Factors Required for Hepatitis C Virus Infection
Hepatitis C virus (HCV), a positive-strand RNA virus, infects more than 170 million people and is the leading cause of liver failure worldwide. A protective vaccine is not yet available. Current interferon-based therapies are only effective in a fraction of patients. Thus, there is an urgent need …
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Control of the Interferon Regulatory Factor - 3 Antiviral Pathway by The Hepatitis C Virus Ns3/4a Protease
Hepatitis C Virus (HCV) is a major human pathogen that affects 200 million people worldwide. A majority of people exposed to HCV become chronically infected. In order to persist, the virus must encode mechanisms to subvert host immune defenses. We hypothesized that HCV disrupts critical host …
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The Role of Interferon Stimlated Genes in Resistance and Immunity to Hepatitis C Virus Infection
Hepatitis C Virus (HCV) is a global public health issue with 170 million people chronically infected. The only approved treatment for HCV infection is interferon-alpha based therapy, resulting in viral clearance in approximately fifty percent of patients treated. Interferon therapy mimics …
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Control of the Interferon Regulatory Factor - 3 Antiviral Pathway by The Hepatitis C Virus Ns3/4a Protease
Hepatitis C Virus (HCV) is a major human pathogen that affects 200 million people worldwide. A majority of people exposed to HCV become chronically infected. In order to persist, the virus must encode mechanisms to subvert host immune defenses. We hypothesized that HCV disrupts critical host …
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Viral and Host Genetic Determinants of Hepatitis C Virus Persistence and Interferon Resistance
Approximately 170 million people worldwide are chronically infected with hepatitis C virus (HCV), which is an important cause of cirrhosis and hepatocellular carcinoma. HCV replicates through an error-prone process that may support the evolution of genetic variants resistant to the host cell …
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Host-Based Mechanisms of Ribavirin Resistance: Implications In Treatment Response of Hepatatis C Virus Infection
Many individuals infected with hepatitis C virus (HCV) fail to respond to therapy, resulting in the development of chronic infection and increased risk for fibrosis, cirrhosis, and hepatocellular carcinoma. The current standard of care consists of pegylated interferon and ribavirin (RBV), a …
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Characterizing B Cell Phenotype During Chronic HCV Infection
Chronic hepatitis C virus (HCV) infection is characterized by an attenuation of virus-specific T cell responses. The mechanisms leading to T cell attenuation are still not well understood, and likely involve several integrating correlates. We hypothesized that dysfunctions of antigen presenting …
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Hepatitis C Virus NS3/4A Protease and the Intracellular Antiviral Response: Mapping Complex Virus-Host Interactions
Virus infection triggers an innate immune response characterized by host cell production of interferon (IFN). Intermediates of viral replication, including dsRNA, initiate a signaling cascade that is amplified within the cell and alerts neighboring cells of viral invaders. Recognition of dsRNA …
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Inhibition of Cell Proliferation through Regulated Intramembrane Proteolysis of CREB3L1
CREB3L1/OASIS is a cellular transcription factor synthesized as a membrane- bound precursor and activated by regulated intramembrane proteolysis in response to stimuli like ER stress. By comparing gene expression between Huh7 subclones that are permissive for hepatitis C virus (HCV) replication …