Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Hep G2"”.
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The effects of herbal extracts and compounds on the glucose metabolism in Hep G2 cells
… and extracts on glucose metabolism in Hep G2 cellular models. The primary objective of this project is to evaluate and compare the metabolic activities of Hep G2 cells after treatment with pure compounds phloretin, ouabain, berberine, and metformin, rebaudioside-A, and extracts of …
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Effects of individual fatty acids on cellular lipid synthesis, lipoprotein secretion, and receptor-mediated lipoprotein uptake in Hep-G2 cells
Restriction data tranferred 2014-07-01T11:14:52-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission
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Regulation of Phospholipid Transfer Protein Secretion and Gene Expression in the Hepatoma Cell Line, HepG2
Hep G2 cells were used as a model to study HDL distribution and interconversion corresponding to variations in PLTP activity. An increase in PLTP activity by butyrate treatment was accompanied by increases in the amount of HDL having a hydrated density of 1.10 g/ml, HDL particle size and the …
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Solid Phase Synthesis and Biological studies on metal conjugates of bioactive peptides for targeted delivery
… microscopy in living liver cancer cells (Hep G2). The metallocene-NLS conjugates were efficiently internalized by the cells and were localised in the nuclei of the Hep G2 cells. The metallocene moiety is responsible for the enhanced cellular uptake of these bioconjugates and the NLS …
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Cloning, sequencing and functional analysis of the chicken tyrosine gene promoter
… crest cells (MQTNC), and human liver cells (Hep G2) by calcium phosphate-mediated transfection. Transfections with all constructs resulted in luciferase activities significantly greater than those that were observed with the promoterless luciferase construct, thus confirming that the 5' …
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Herstellung und Charakterisierung einer induzierbaren Form des Transkriptionsfaktors FOXO1a
… (ER) to the C-terminus of FOXO1a (FOXO1a-ER). In HEP-G2-cells transiently transfected with plasmids encoding the FOXO1a-ER fusion protein and a glucose-6-phosphatase reporter construct, hydroxytamoxifen induced a marked induction of glucose-6-phosphatase promoter activity, whereas no effect was …
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The Liver as a Target Organ for the Non-Genomic Actions of Estrogen
… ligand and electron microscopy of Hep G2 cells to directly visualize the uptake and translocation of the ligand. I confirm the receptor-mediated endocytosis of the ligand and identify the mitochondria as an intracellular target for the ligand. Using affinity chromatography, I …
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Elucidating the biology of G-protein coupled receptor 35
… cancer models. siRNA knockdown of GPR35 in Hep-G2 cells led to reduced cellular proliferation which was found to be related to osmotic stress, as shown by activation of the p38 MAPK pathway and rescue of the proliferative defect in a low salt environment. Finally, we performed large scale …
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A Dual-GFP Reporter System for Studying Bi-Directional Promotion
… linear range. The background autofluorescence of Hep G2 cells was low and remained stable during the time frame of the experiments. The reorientation of the reporter gene or insertion of a reoriented reporter and its promoter did not significantly affect the background fluorescence of a …
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Synthesis and evaluation of novel heterocyclic compounds as anticancer agents
… the growth of A549, U-2 OS, BEAS-2B, Saos-2, Hep-G2, and A204 mammaliancell lines by MTT assay, and flowcytometry. 3-Hydroxy-4-methoxy-N-(2-((3,4,5-trimethoxybenzyl)amino)pyridin-3-yl)benzenesulfonamide, was the most potentcompound evaluated with an IC50 of 1.15µM in the Carcinoma A549 cell …
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Growth Hormone and Nutritional Regulation of Insulin-Like Growth Factor-I Gene Expression
… containing these two STAT5-binding sites in Hep G2 cells, and this binding was associated with increased expression of IGF-I mRNA. These two STAT5-binding sites were also able to mediate GH-induced STAT5 activation of gene expression in reconstituted GH-responsive cells. These results …
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MS-Based Chemical Proteomics Studies of Extracellular Glycoproteins: Identification, Quantification, and Dynamics
… response to bacterial infection model and from Hep G2 cells during the EMT process. Additionally, the reduction and alkylation steps of the bottom-up proteomics workflow are optimized to maximize the number of proteins and peptides that can be identified by MS. An enrichment step with thiopropyl …
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Characterisation of a novel bioactive complex polysaccharide from a marine invertebrate with potent anticancer and antimalarial activities
… of protein HER2- SKBR3 cell line, the hepatoblastoma-derived cell line (Hep G2), chronic myelogenous leukaemia (K562), TNBC and mammosphere formation in breast cancer subtypes, and on malaria has been investigated in vitro using drug sustainable assays. Focusing on TNBC, the label-free …
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Silver (I) Complexes as Antimicrobial and Anticancer Drugs
… carboxylates, such as polymeric [Ag2(9-aca)2]n and [Ag2(9-aca)2(DMSO)2]n, and the ammoniacontaining complex, [Ag4(9-aca)4(NH3)2], are provided along with imidazole derivatives, such as [Ag2(9-aca)2(DMSO)2]n and [Ag6(imidH)4(9-aca)6(MeOH)2]. Silver(I) carboxylates containing …
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Untersuchungen zur Expression und subzellulären Lokalisation von Isoformen des Adaptorproteins Kanadaptin
… humanen Zelllinien (z. B. U-373, SW-480 und Hep-G2, A-431, MCF-7, PC-3) wurde Kanadaptin sowohl auf Protein- als auch auf Transkriptionsebene (RT-PCR) nachgewiesen. In Mäuseembryonen wurde Kanadaptin im Western-Blot erstmals am 9. Embryonaltag detektiert. An gefriergetrockneten …
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Apolipoprotein biosynthesis and turnover in mammalian small intestine
… studies of apolipoprotein B dynamics in isolated hepatocytes and in the hepatoma-derived liver cell line, Hep G2. The mechanisms underlying these phenomena are as yet unresolved.
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Analytik von phenolischen Substanzen und Epoxiden in Materialien mit Lebensmittel- und/oder dermalem Kontakt
… nach DIN 38415-T647 und/oder Neutralrottest an Hep-G2 und HT-29 Zellen untersucht. Die stärksten Effekte im Fischembryotest bewirkte das Trimer BPM, hier reichte bereits eine Konzentration von etwa 2 mg/l aus, um 50 % der Fischembryonen letal zu schädigen. Im Gegensatz dazu waren beim Dimer …
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Glycan-based biomarkers for the quality assurance in stem cell therapy
… der Zelllinien HEK 293, CHO-K1, AGE1.HN und Hep G2 getestet. Die Ergebnisse zeigten, dass die N-Glykosylierung der Zelloberfläche der untersuchten Zelllinien strukturell die Hauptmerkmale der Glykoproteine aufwiesen, welche rekombinant in ihnen produziert werden. Unter Verwendung der neu …
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Einfluss von freien Fettsäuren und Triglyceriden auf die Expression von proinflammatorischen Mediatoren und Adhäsionsmolekülen in Hepatozyten und Kupffer-Zellen (der Ratte)
… dieser Erkrankung, Steatosis sowie Steatohepatitis, auf eine exzessive Exposition von freien Fettsäuren und inflammatorischen Zytokinen zurückzuführen sind. Der exakte Pathomechanismus, der die Progression einer NAFLD zu dem schweren Krankheitsbild einer NASH beschreibt, ist bis auf …