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Showing 1 to 17 of 17 for “"Hemorrhagic Shock"”.
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Effects of Ubiquinol with Fluid Resuscitation following Hemorrhagic Shock
Abstract Hemorrhagic shock (HS) and fluid resuscitation triggers ischemia-reperfusion injury in cells and increases the production of reactive oxygen species (ROS) which are known to activate the intrinsic pathway of apoptosis and contribute to organ dysfunction.1 Ubiquinol is a potent free radical …
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The role of nitric oxide and prostaglandin E2 in prolonged hemorrhagic shock
… played a major role in our model of prolonged hemorrhagic shock. The detrimental effects of NO might be further worsen when coupled with prostaglandin E2, a known vasodilator, in prolong hemorrhagic shock. Nitric oxides being a vasodilator might be responsible for the loss of vascular …
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A role for renal prostaglandin E in hemorrhagic shock in the dog
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The use of near infrared spectroscopy in detecting hemorrhagic shock in swine
A hemorrhagic shock study was performed at the U.S. Army's Institute for Surgical Research in San Antonio, Texas. Surgery was performed on a total of 35 swine averaging between 34-44 kg. The intention of the experimental surgery was to most accurately simulate a human internal uncontrolled …
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Enalaprilat Improves Systemic and Mesenteric Blood Flow During Normotensive Resuscitation from Hemorrhagic Shock in Dogs
… In this study involving resuscitation fiom hemorrhagic shock in dogs, the systemic and mesenteric cardiovascular effects of administering enalaprilat during resuscitation were investigated. Thermodilution-based and ultrasound-based methods of monitoring the systemic blood flow were also …
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Cytokine and Chemokine Profiles in a Rat Model of Hemorrhagic Shock after Immuno-Modulation by Androstenetriol
Further understanding of the cellular and molecular mechanisms involved in traumatic injury, and how they are modulated during drug interaction, can facilitate novel treatment strategies for future trauma patients. We hypothesize that the pharmacological agent, Androstenetriol (AET), up regulates …
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Validation of tissue oxygen saturation determined by near-infrared spectroscopy in canine models of hypoxemia and hemorrhagic shock
The objective of this study was to evaluate the relationship between tissue oxygen saturation (StO2) and oxygen delivery index (DO2I). Oxygen delivery index is product of two factors arterial oxygen content (CaO2) and cardiac index (CI). In this study the relationship between DO2I and StO2 was …
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Myocardial Contractility in Experimental Hemorrhagic Shock: An Evaluationof the Role of Blood Replacement, L-Norepinephrine, Tris-(hydroxymethyl) Aminomethane, and Oxygen in the Maintenance of Myocardial Homeostasis
Made available in DSpace on 2014-12-09T23:33:52Z (GMT). No. of bitstreams: 1 6511831.pdf: 5725506 bytes, checksum: b095d20b1116335fd08b1ebfe7a1c976 (MD5) Previous issue date: 1965
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Zur Wirkung von Vasopressin beim unkontrollierten hämorrhagischen Schock
… Resuscitation for the Treatment of Uncontrolled Hemorrhagic Shock, an Experimental Approach in a Porcine Liver Trauma Model The standard approach to the traumatized victim in uncontrolled hemorrhagic shock is to infuse large amounts of crystalloid and colloid fluids as early, and as rapidly as …
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Role of ROK and PKC in Permeabilized Rabbit Femoral Artery
… vasospasm, and vascular hyporeactivity following hemorrhagic shock may be possible. Studies have shown that KCl-induced contractions induce Ca2+-sensitization. Therefore, we tested the hypothesis that KCl induced Ca2+-sensitization is due to ROK activation by the increase in [Ca2+]i. To test this …
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Effekte stromafreier Hämoglobinlösungen auf die Mikrozirkulation im quergestreiften Rückenhautmuskel beim Hamster
… respectively. For pathophysiologic conditions a hemorrhagic shock as a stress model was induced by non-fractioned withdrawal of half the calculated blood volume within a few minutes, and treated by volume substitution with the respective solutions. Our results demonstrate that the application of …
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Identification of Multiple Levels of Trauma Induced Coagulopathy
… function during trauma and the resulting shock from exsanguination, a multipronged approach was developed. The hypothesis that the introduction of a state of clinical shock in a controlled environment would allow for an in-depth assessment of trauma-induced coagulopathy led to the …
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Membrane Stabilizing Copolymer Poloxamer 188 in Preclinical Models of Acute Myocardial Infarction Reperfusion
… risk of death by secondary cardiac events like hemorrhagic shock and cardiac arrest remain very high. Cellular injury after acute myocardial infarction occurs in two stages- ischemic injury, which occurs when there is a myocardial oxygen supply-demand mismatch, and reperfusion injury, which …
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Synthesis of Novel Cannabinoid Ligands and Their Use as Anti-Glioma and Anti-Inflammatory Agents
… Parkinson’s disease, epilepsy, glaucoma, septic shock, hemorrhagic shock, and cancer. Our research has focused on two major conditions for which cannabinoids hold great promise for drug development, namely, cancer and inflammation.</p> <p>Our focus in the field of cancer has been on the …
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Der Einfluss von Stickstoffmonoxid auf die schockinduzierte Hämoxygenase-1 Expression in der Leber der Ratte
Neuere Studien legen nahe, daß die hepatische Expression der Hämoxygenase-1 (HO-1) vor hepatozellulären Schäden nach hämorrhagischem Schock (HS) und Reperfusion schützen kann. Über die Regulation der HO-1 ist bisher nur wenig bekannt. In kultivierten Zellen in vitro konnte gezeigt werden, daß …
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Penetrating cardio-thoracic injuries at a district level hospital in Cape Town South Africa : A retrospective case audit
… the 56 operated patients, 37 (66%) presented in hemorrhagic shock with SBP < 90mmHg. The mean amount of resuscitation fluid, which included both crystalloid and colloid, administered in the Emergency Room (ER) was 2481 ml per patient. Ten (17.8%) patients had a front room thoracotomy (FRT), with …
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Expressionsmuster der Adhäsionsmoleküle P-Selektin, von Willebrand-Faktor und PECAM-1 in der Lunge von Todesfällen durch Verbrennungsschock versus Verblutungsschock
Für eine Differenzierung der Todesursache "Verbrennungsschock" und "Verblutungsschock" wurden die Lungenpräparate von jeweils 30 Fällen aus dem Sektionsgut des Rechtsmedizinischen Instituts der Universität Freiburg anhand immunhistochemischer Färbungen mit P-Selektin, von-Willebrand-Faktor (vWF) …