Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Hemolytic Anemia"”.
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A Study of the Effect of Methylene Blue on Lactate Metabolism of the Dog Erythrocyte
… of methylene blue to dogs resulted in a hemolytic anemia, He noted that the degree of anemia was proportional to the amount of dye administered (over the dose range used), and that if the dose was quite high, hemoglobinuria and hemoglobinonia occured. In 1934, Wendel and Ilafley (2) …
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Effect of Increase and Decrease In Erythrocyte Volume Upon Plasma Volume and Total Blood Volume
… and his co-workers in this department produced a hemolytic anemia in dogs by the administration of methylene blue. It was then desirable to know if this were a true anemia or if plasma volume shifts occurred which gave a picture of anemia while it did not actually exist. It is the purpose of this …
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Subclinical Cytomegalovirus Infection in Neonates: Its Effect on Intellectual and Auditory Functioning.
… hepatosplenomegaly, purpura, erythroblastic or hemolytic anemia, central nervous system disease (Stem, Booth, Eleck and Fleck, 1969). In addition, thrombocytopenia, chorioretinitis, pneumonia and diarrhea also may be found (Emmanuel and Kenny, 1966 ; Medearis, 1964, and Weller and Hanshaw, …
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Glutathione synthetase: Conserved residues of the substrate loop
… glutathione synthetase (hGS) deficiency causes hemolytic anemia, metabolic acidosis, 5-oxprolinuria and a total deficiency may be lethal. Three flexible loops (A, G and S) surround the substrates (ATP, glycine and γ-GC). Human glutathione synthetase is negatively cooperative to one substrate, …
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Insights into the Iimmune Mechanisms Leading to Lupus-like Autoimmunity in New Zealand Black Mice
… IgG autoantibodies and development of hemolytic anemia and kidney disease. Polyclonal B cell activation, expansion of plasmacytoid dendritic cells (pDC), and elevated gene expression of baff were maintained in CD40L-deficient NZB mice, despite the lack of IgG immune complexes. Chapter 3 …
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Different Methodologies to Characterize and Diagnose Sickle Cell Disease in Both Developed and Developing Nations
… capacity of RBC resulting in painful crisis, hemolytic anemia, and infection susceptibility. SCD affects around 100,000 individuals in USA alone and 14 million people globally. SCD affected individuals have high mortality rates. Early detection and constant monitoring of this disease is …
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Effects of Sickle Cell Disease on Growth of the Craniofacial Complexes
… probably as a result of chronic hypoxia due to hemolytic anemia. (2) There was no discernible difference in severity between SC and SS genotypes. (3) In contrast, females regardless of genotype typically were more severely affected than males. (4) Children became progressively more affected with …
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Bioactivation of diacetyldapsone in cultured lung cells
… adverse effects, including methemoglobinemia, hemolytic anemia and photosensitivity reactions. To reduce the adverse effects associated with oral dapsone, an alternative would be to administer the prodrug diacetyldapsone (DADDS) into the lung, which may be hydrolyzed to monoacetyldapsone and …
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Genetic and Chemical Genetic Approaches to Shiga Toxin Inhibition
… can place patients at risk of developing hemolytic uremic syndrome, a toxemic condition characterized by hemolytic anemia, thrombocytopenia, and acute renal failure. Though hemolytic uremic syndrome remains the leading cause of acute renal failure in children under the age of 5, treatment …
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HEPATIC LIPID METABOLISM: THE ROLES OF ACAT2 AND ABCG5/G8 IN THE DEVELOPMENT AND PREVENTION OF DISEASE
… E-rich lipoprotein (ERL), hepatosplenomegaly, hemolytic anemia, and myocardial infarction in response to high dietary phytosterol retention. Our results show that ACAT2 and G5G8 have contrasting roles in modulating free sterol metabolism, suggesting a critical role for hepatic expression of …
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Reactions of Nitroxyl and Nitrite in Blood
… for conditions such as hypertension, hemolytic anemia, heart failure, and ischemia reperfusion injury.
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Characterization of OmpT: An outer membrane vesicle protease Escherichia coli that attenuates blood coagulation.
… colitis, renal failure, bloody diarrhoea, hemolytic uremic syndrome, thrombocytopenia, hemolytic anemia and other systemic problems. E. coli O157:H7 is responsible for outbreaks of Enterohemorrhaghic E. coli infections and causes significant mortality and morbidity globally. Factor V …
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Managing alloimmunization, delayed hemolytic transfusion reactions, and hyper-hemolysis in sickle cell disease
… a sickled shape of red blood cells, leading to anemia due to premature destruction of RBCs. Other morbidities include end-organ damage, pain attacks known as “sickle cell crisis,” bacterial infections, and stroke. Transfusion therapy remains a necessary treatment of sickle cell disease. …
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Characterization of Complement C3 Dysregulation Predisposing to Two Human Disease States
… leads to a secondary C3 deficiency. Atypical hemolytic uremic syndrome: aHUS) is a thrombotic microangiopathy that primarily affects the kidneys. This disease is characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Heterozygous mutations in the …
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Anemia hemolítica secundaria a timoma sin miastenia gravis como síndrome paratímico: Presentación de un caso
… con el reporte de patología. Además cursa con anemia hemolítica e hipotiroidismo autoinmune, sin miastenia gravis asociada.
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Diagnostic techniques for detecting exposure and anemia in birds exposed to crude oil
Oil spills have long been recognized as a significant threat to wildlife. Historically, mortality estimates have served as the basis for assessing impact to natural resources. However, these mortality estimates alone neglect the more wide-spread impact of oil spills on wildlife including birds, …