Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Hemolytic Activity"”.
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Assessment of motility and hemolytic activity in clinical isolates of Acinetobacter baumannii from University of Kentucky hospital, Lexington, KY
… ability to cause human disease, such as hemolytic activity and surface motility. The aim of this study was to determine the presence of these two virulent traits in clinical isolates. Forty-eight clinical isolates were recovered from University of Kentucky hospital in Lexington, KY. No …
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Activation State of Human T and NK Cells Increases Sensitivity to Death by Streptococcus pneumoniae
… factor. In this study, we investigated the hemolytic activity of Spn lysates of several different pneumococcal serotypes. We showed the hemolytic activity of Spn correlated with CD8 T cell, CD4 T cell, and NK cell survival. Looking further, we identified that lymphocytes incubated with Spn …
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Chemoenzymatic synthesis of an analogue of the potent antifungal mycosubtilin
… that also displays limited antibiotic activity. Structurally, mycosubtilin is a macrocycliclipoheptapeptide of sequence Asn-Tyr-Asn-Gln-Pro-Ser-Asn, with the N-terminal Asn joined by a β-amino fatty acid. Besides the antifungal and antibiotic activities,these molecules are also …
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Cationic amphiphilic synthetic macromolecules with superior antibacterial activity
… amphiphilic macromolecules with antimicrobial activity and very low hemolytic impact. Synthetic amphiphilic polymers attack bacteria directly to rupture the cell membrane through electrostatic and hydrophobic interactions. However, the toxicity of such synthetic amphiphilic polymers against …
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Treponema hyodysenteriae: growth and production of hemolysin
… 1 % 02 and stirring of the culture. l\laximal hemolytic titers were obtained during late-log to early-stationary phase by cultures grown in the presence of RNA core. Hemolysin production was induced as soon as 5 minutes after addition of RNA core to cultures. This production was inhibited by …
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Structural and Biological Characterization of Antimicrobial Peptides from Rana Sylvatica and Kassina Senegalensis
… were synthesized to improve antimicrobial activity, and two peptides were co-incubated for synergistic effects. Two peptides, termed kassinatuerins 1 and 2, from the skin of the African running frog, Kassina senegalensis, and one peptide, termed brevinin 1SY (SY for sylvatica), from the …
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Modulation of Antibacterial Activity and Cytotoxicity in Amphipathic Cyclic Peptide [R4W4] Using Histidine Substitution
… among known AMPs that demonstrated antimicrobial activity against methicillin-resistant staphylococcus aureus (MRSA) with a minimum inhibitory concentration (MIC) of 2.67 μg/mL. This peptide had notably effective antimicrobial activity, especially relative to linear (R4W4). However, it displayed a …
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Use of solution-state nuclear magnetic resonance spectroscopy to determine the structures of medicinally relevant peptides and proteins
… unique among bacteriocins in that it has hemolytic activity in addition to bactericidal activity. Nisin, the prototypical lantibiotic, was studied in the context of the immunity protein, NisI, which is believed to confer immunity against lysis to the producing organism. The final system …
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Assessment of microbial quality and safety of ground beef/product sold in differrent retailers around Thohoyandou Area, Vhembe District, Limpopo
… and VITEK system. Moreover, the antibiogram activity of isolated pathogens was screened against medically used and commercially available antibiotics. Furthermore, the DNA of the isolates was extracted, and multiplex PCR was conducted to determine different virulence genes and pathotypes. …
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<em>Actinobacillus pleuropneumoniae</em> ApxI and ApxII Toxin Regulation
… North America. Further characterization of these hemolytic toxins is needed to fully understand their role in disease and elucidate the environmental signals and genes that affect their production during infection. The goal of this project was to examine environmental signals that could be …
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The production, design and application of antimicrobial peptides
… effective systemic doses are to be given without hemolytic activity or other toxicity. Improved high-throughput methods for AmP design or discovery could enable the achievement of both of these goals. To this end, we developed an approach based on the discovery of semi-conserved motifs across …
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Synthesis and Evaluation of Tetramic Acids as Antimicrobial Agents
… of natural products exhibiting antimicrobial activity possess a tetramic acid (2,4-pyrrolidinedione) functional group. As their antibacterial mechanism of action is different from that of many of the currently available antibiotics, these compounds have potential to serve as a basis for a …
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Repurposing Antibacterial Compounds and Natural Products to Combat Vancomycin-Resistant Enterococci
… to target Clostridioides difficile, for their activity against VRE. Both compounds showed exceptionally low minimum inhibitory concentrations and were bacteriostatic against VRE in vitro. In a Caenorhabditis elegans infection model, treatment with either compound significantly reduced the …
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Untersuchungen zu Bacillus cereus Enterotoxin-Komplexen auf zellulärer Ebene
This paper deals with the in vitro activity of the B. cereus enterotoxin-complexes Hemolysin BL (HBL) and non-hemolytic enterotoxin (Nhe) on cells. For that purpose the cytotoxic and hemolytic activity of crude B. cereus culture supernatants was analyzed in cell culture assays and on blood agar …
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CcpA-Mediated Carbon Catabolite Repression of Virulence in the Group A Streptoccus
… cytolysin, streptolysin S (SLS). Moreover, hemolytic activity due to SLS was increased in the delta ccpA strain, and expression from Psaga demonstrated strong catabolite repression during growth in glucose compared to sucrose. Furthermore, purified GAS CcpA was shown to bind directly to the …
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Evidence of Water to Human Transmission of Aeromonas Hydrophila: Critical Role of Quorum Sensing in Bacterial Virulence & Host Response
… the cytotoxic enterotoxin, which has associated hemolytic activity.
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Mechanistic and synthetic studies on the prochlorosin and cytolysin families of lanthipeptides
… (RiPPs) that commonly feature antibacterial activity and contain the characteristic thioether residues lanthionine (Lan) and methyllanthionine (MeLan). Installation of thioether crosslinks in lanthipeptide biosynthesis is carried out by designated synthetases and involves dehydration of …
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DEVELOPMENT OF NOVEL COPOLYOXETANES: ANTIMICROBIAL AGENTS
… Cx-m copolyoxetane antimicrobial efficacy, hemolytic activity and cytotoxicity were further explored by changing quaternary alkyl chain length. Copolyoxetanes are represented as Cx-50, where 50 is the mole percent quaternary repeat units and ‘x’ is quaternary alkyl chain length (2 to 16 …
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Identification et caractérisation de bactériocines produites par deux bactéries lactiques (Enterococcus faecium CWBI-B1430 et Enterococcus mundtii CWBI-B1431) isolées à partir de fromages frais artisanaux péruviens
… bacteria (LAB) with bacteriocin-like inhibitory activity against Listeria monocytogenes was performed. The screening was conducted in 27 traditional artisanal-produced cheeses obtained from different Peruvian regions. Two thousand two hundred and seventy seven strains (2277) were isolated, of …
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