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Showing 1 to 20 of 461 for “"Hemoglobin"”.
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Nitric Oxide Bioavailability Regulation by Hemoglobin
… pressure, and cause other deleterious effects. Hemoglobin, the oxygen-carrying protein in blood, reacts rapidly with NO. Normally, however, hemoglobin is encapsulated within red blood cells. This limits its proximity to the endothelial cell layer, restricting its uptake rate of NO. Several …
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Studies on the Chemistry of Human Hemoglobin
… concerned with the confirmation of adult human hemoglobin in solution. It is now well established that one form of the hemoglobin molecule is composed of four polypeptide chains, two α chains, and two β chains, held together by non-covalent bonds. The linear sequence of amino acids in both the α …
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Hemoglobin Differentiation in the Bullfrog, Rana Catesbeiana
Made available in DSpace on 2014-12-09T23:33:51Z (GMT). No. of bitstreams: 1 6500809.pdf: 3414432 bytes, checksum: c0d622a70284bceb7f36bd588f662b08 (MD5) Previous issue date: 1964
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A Free Heme Perspective to Sickle Hemoglobin Polymerization
Sickle cell hemoglobin (HbS) polymerization is considered to be the primary pathogenic event in the sickle cell anemia. Many cellular and molecular factors have been identified so far as contributor towards the polymerization event. The free heme, prosthetic group of hemoglobin, is one such small …
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The effect of the menstrual cycle on hemoglobin mass
… either reductions or no significant changes in hemoglobin concentration during the follicular phase when compared to the luteal phase of the menstrual cycle. Changes in plasma volume associated with fluctuating estrogen and progesterone levels likely contribute to the variations in hemoglobin …
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Biophysical Studies Aimed at Potential Therapies of Hemoglobin Associated Diseases
Hemoglobin (Hb), the most abundant protein found in the red blood cell (RBC), carries gases like oxygen and carbon dioxide throughout the body. However, various conditions, both genetic and environmental, can impede its ability to perform this (and other) necessary functions. We studied some of the …
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SYNTHESIS, TESTING AND CRYSTALLOGRAPHIC STUDIES OF ALLOSTERIC MODIFIERS OF HEMOGLOBIN
The major physiological function of hemoglobin (Hb) is to bind, transport and deliver oxygen to tissues; made efficient by endogenous effectors, such as protons and 2,3-diphosphoglycerate. Synthetic allosteric effectors of Hb (AEHs) are also known to modulate Hb oxygen affinity, showing potential …
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Patient Activation and Self-Management of Hemoglobin A1C among Filipinos
… lipoprotein level (LDL), and self-management of hemoglobin A1c (HbA1c) among Filipinos with Diabetes Mellitus (type 1 and type 11).</p> <p><strong>Methods:</strong> A non-experimental cross-sectional design to collect prospective data among Filipinos with Diabetes Mellitus. Descriptive statistics …
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Hemoglobin Alc: Structure, Biosynthesis and Clinical Significance In Diabetes Mellitus
… in the peripheral blood concentration of hemoglobin A1C. This minor red cell component comprises 3-5 per cent of the total hemoglobin in non-diabetic humans but up to 15 per cent in diabetics. There is evidence to suggest that it is a glycosylated derivative of hemoglobin A. The aim of …
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Recombinant Hemoglobin Variants: Structure-Function Analysis and Oxygen Therapeutic Design
… the first recombinantly designed polymerized hemoglobin. The clear structural and functional similarity of these variants to native hemoglobin and improved vascular stability suggests that they have potential for use as an oxygen carrying therapeutic.
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Hemoglobin A1c and Prediction of Cardiovascular Disease and All-Cause Mortality
… will seek to evaluate the role of a biomarker, hemoglobin A1c, as a predictor of incident cardiovascular disease and all-cause mortality in a multi-ethic population free of cardiovascular disease and diabetes at the baseline. Atherosclerotic cardiovascular disease is a significant cause of …
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The Ratio of Heinz Body Formation in Different Hemoglobin Zurich Subjects
<p>Hemoglobin Zurich is a hemoglobin anomaly that results when one amino acid (histidine) is substituted by arginine at position 63 in the beta chain of hemoglobin molecules [β 63 His—Arg]. When Hemoglobin Zurich individuals are exposed to sulfonamide medication, their hemoglobins denature and …
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Predictive models in near-infrared spectroscopic analysis for blood hemoglobin prediction
Determination of blood hemoglobin concentration is important to diagnose anaemia. Common clinical practice used to measure blood hemoglobin is by drawn some blood from the patient to be mixed with reagent chemicals for analysis. Alternatively, near-infrared spectroscopy (NIRS) technology can be …
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Genomics of sickle cell disease and fetal hemoglobin in African populations
… therapy is therefore an imperative. Fetal hemoglobin (HbF) has long been recognized to ameliorate SCD severity whereby patients harboring natural genetic variations that lead to the persistence of high HbF levels in their blood tend to live longer with fewer complications. The HbF …
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