Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Hemizygosity"”.
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Exploring SARM1 as a target to delay programmed axon degeneration
… completely eliminating them, the effect of Sarm1 hemizygosity in mice was assessed. Data presented here show that the rate of programmed axon degeneration can be slowed by the absence of one allele after in vivo transection injury, and axon outgrowth deficits in a developmental system where the …
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Patterns of linkage disequilibrium in the human genome
… as the advantages afforded to haplotyping due to hemizygosity of the X chromosome in males. Major conclusions include the observation that LD between pairs of markers is highly variable even at extremely close distances and multimarker haplotypes better serve to resolve the underlying haplotype …
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The genetic and developmental bases of male genital organ size evolution
… underlying clasper development. The reciprocal hemizygosity test showed that tartan (trn), underlies clasper size evolution between these species. Trn is a Leucine Rich Repeat transmembrane protein, and is the first gene identified underlying genital organ size differences between species. …
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The genetic basis of reproductive isolation in house mice: Studies of a European hybrid zone
… and inheritance patterns of the X chromosome (hemizygosity). Additionally, loci closely linked to the targets of selection show only weak reductions in introgression, suggesting that neutral gene flow is not strongly impeded by selection against hybrids. Finally, the mouse genome sequence is …
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The pathological and genomic impact of CTCF depletion in mammalian model systems
… in a hepatocyte-specific mouse model of Ctcf hemizygosity with diethylnitrosamine-induced liver tumours. Ctcf hemizygous mice had a subtle liver-specific phenotype, although the overall tumour burden in Ctcf hemizygous and wild-type mice was the same. Using whole genome sequencing, the highly …
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The genetic mechanisms that coordinate the development and morphological divergence of Drosophila genital structures
… evolved between species, I conducted reciprocal hemizygosity tests and found that posterior lobe size and shape differences are causative of Sox21b evolution between D. simulans and D. mauritiana. I then isolated an enhancer driving Sox21b expression in the posterior lobe primordia, which is …